FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2151264561> ?p ?o ?g. }

• W2151264561 endingPage "115" @default.
• W2151264561 startingPage "104" @default.
• W2151264561 abstract "To identify molecular effects of the antineoplastic agent protein kinase C inhibitor 412 (PKC412) (midostaurin), we applied gene expression profiling in zebrafish using whole-genome microarrays. Behavioral, developmental, and physiological effects were investigated in order to analyze for correlations between altered gene expression profiles with effects on development and physiology. Zebrafish blastula-stage embryos were exposed for 6 days postfertilization to nominal levels of 2 and 40 μg/l PKC412. Among the 259 and 511 altered transcripts at both concentrations, respectively, the expressions of genes involved in the circadian rhythm were further investigated. Alteration of swimming behavior was not observed. Pathways of interest affected by PKC412 were angiogenesis, apoptosis, DNA damage response, and response to oxidative stress. Angiogenesis was analyzed in double-transgenic zebrafish embryos Tg(fli1a:EGFP)y1;Tg(gata1:dsRed)sd2; no major defects were induced by PKC412 treatment at both concentrations. Apoptosis occurred in olfactory placodes of embryos exposed to 40 μg/l, and DNA damage was induced at both PKC412 concentrations. However, there were no significant effects on reactive oxygen species formation. This study leads to the conclusion that PKC412-induced alterations of gene transcripts are partly paralleled by physiological effects at high, but not at low PKC412 concentrations expected to be of environmental relevance." @default.
• W2151264561 created "2016-06-24" @default.
• W2151264561 creator A5007298493 @default.
• W2151264561 creator A5011936587 @default.
• W2151264561 creator A5034815277 @default.
• W2151264561 creator A5049455005 @default.
• W2151264561 creator A5050819567 @default.
• W2151264561 creator A5054947770 @default.
• W2151264561 date "2010-10-27" @default.
• W2151264561 modified "2023-10-14" @default.
• W2151264561 title "Effects of the Protein Kinase Inhibitor PKC412 on Gene Expression and Link to Physiological Effects in Zebrafish Danio rerio Eleuthero-Embryos" @default.
• W2151264561 cites W1573363574 @default.
• W2151264561 cites W1608086260 @default.
• W2151264561 cites W1964495288 @default.
• W2151264561 cites W1970017082 @default.
• W2151264561 cites W1977494365 @default.
• W2151264561 cites W1986826174 @default.
• W2151264561 cites W1998222695 @default.
• W2151264561 cites W2004199183 @default.
• W2151264561 cites W2004617594 @default.
• W2151264561 cites W2011801630 @default.
• W2151264561 cites W2013403013 @default.
• W2151264561 cites W2026765020 @default.
• W2151264561 cites W2034459264 @default.
• W2151264561 cites W2034989670 @default.
• W2151264561 cites W2036668890 @default.
• W2151264561 cites W2046710025 @default.
• W2151264561 cites W2050338667 @default.
• W2151264561 cites W2059549751 @default.
• W2151264561 cites W2060355405 @default.
• W2151264561 cites W2066888615 @default.
• W2151264561 cites W2073404756 @default.
• W2151264561 cites W2077784250 @default.
• W2151264561 cites W2084691395 @default.
• W2151264561 cites W2091760375 @default.
• W2151264561 cites W2091767953 @default.
• W2151264561 cites W2093336699 @default.
• W2151264561 cites W2095661228 @default.
• W2151264561 cites W2100772783 @default.
• W2151264561 cites W2101020025 @default.
• W2151264561 cites W2112528263 @default.
• W2151264561 cites W2125349610 @default.
• W2151264561 cites W2130426061 @default.
• W2151264561 cites W2140459348 @default.
• W2151264561 cites W2145937475 @default.
• W2151264561 cites W2150176491 @default.
• W2151264561 cites W2152215024 @default.
• W2151264561 cites W2319461533 @default.
• W2151264561 cites W4234625062 @default.
• W2151264561 doi "https://doi.org/10.1093/toxsci/kfq330" @default.
• W2151264561 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20980353" @default.
• W2151264561 hasPublicationYear "2010" @default.
• W2151264561 type Work @default.
• W2151264561 sameAs 2151264561 @default.
• W2151264561 citedByCount "12" @default.
• W2151264561 countsByYear W21512645612012 @default.
• W2151264561 countsByYear W21512645612013 @default.
• W2151264561 countsByYear W21512645612015 @default.
• W2151264561 countsByYear W21512645612016 @default.
• W2151264561 countsByYear W21512645612017 @default.
• W2151264561 countsByYear W21512645612020 @default.
• W2151264561 countsByYear W21512645612022 @default.
• W2151264561 crossrefType "journal-article" @default.
• W2151264561 hasAuthorship W2151264561A5007298493 @default.
• W2151264561 hasAuthorship W2151264561A5011936587 @default.
• W2151264561 hasAuthorship W2151264561A5034815277 @default.
• W2151264561 hasAuthorship W2151264561A5049455005 @default.
• W2151264561 hasAuthorship W2151264561A5050819567 @default.
• W2151264561 hasAuthorship W2151264561A5054947770 @default.
• W2151264561 hasBestOaLocation W21512645612 @default.
• W2151264561 hasConcept C104317684 @default.
• W2151264561 hasConcept C143425029 @default.
• W2151264561 hasConcept C150194340 @default.
• W2151264561 hasConcept C153911025 @default.
• W2151264561 hasConcept C18431079 @default.
• W2151264561 hasConcept C196843134 @default.
• W2151264561 hasConcept C2776878037 @default.
• W2151264561 hasConcept C2780384893 @default.
• W2151264561 hasConcept C54355233 @default.
• W2151264561 hasConcept C552990157 @default.
• W2151264561 hasConcept C86803240 @default.
• W2151264561 hasConcept C95371953 @default.
• W2151264561 hasConcept C95444343 @default.
• W2151264561 hasConceptScore W2151264561C104317684 @default.
• W2151264561 hasConceptScore W2151264561C143425029 @default.
• W2151264561 hasConceptScore W2151264561C150194340 @default.
• W2151264561 hasConceptScore W2151264561C153911025 @default.
• W2151264561 hasConceptScore W2151264561C18431079 @default.
• W2151264561 hasConceptScore W2151264561C196843134 @default.
• W2151264561 hasConceptScore W2151264561C2776878037 @default.
• W2151264561 hasConceptScore W2151264561C2780384893 @default.
• W2151264561 hasConceptScore W2151264561C54355233 @default.
• W2151264561 hasConceptScore W2151264561C552990157 @default.
• W2151264561 hasConceptScore W2151264561C86803240 @default.
• W2151264561 hasConceptScore W2151264561C95371953 @default.
• W2151264561 hasConceptScore W2151264561C95444343 @default.
• W2151264561 hasIssue "1" @default.
• W2151264561 hasLocation W21512645611 @default.

• next