FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2151276427> ?p ?o ?g. }

• W2151276427 endingPage "5396" @default.
• W2151276427 startingPage "5387" @default.
• W2151276427 abstract "ABSTRACT Cationic antimicrobial peptides (CAMPs) are important components of the innate host defense system against microbial infections and microbial products. However, the human pathogen Neisseria meningitidis is intrinsically highly resistant to CAMPs, such as polymyxin B (PxB) (MIC ≥ 512 μg/ml). To ascertain the mechanisms by which meningococci resist PxB, mutants that displayed increased sensitivity (≥4-fold) to PxB were identified from a library of mariner transposon mutants generated in a meningococcal strain, NMB. Surprisingly, more than half of the initial PxB-sensitive mutants had insertions within the mtrCDE operon, which encodes proteins forming a multidrug efflux pump. Additional PxB-sensitive mariner mutants were identified from a second round of transposon mutagenesis performed in an mtr efflux pump-deficient background. Further, a mutation in lptA , the phosphoethanolamine (PEA) transferase responsible for modification of the lipid A head groups, was identified to cause the highest sensitivity to PxB. Mutations within the mtrD or lptA genes also increased meningococcal susceptibility to two structurally unrelated CAMPs, human LL-37 and protegrin-1. Consistently, PxB neutralized inflammatory responses elicited by the lptA mutant lipooligosaccharide more efficiently than those induced by wild-type lipooligosaccharide. mariner mutants with increased resistance to PxB were also identified in NMB background and found to contain insertions within the pilMNOPQ operon involved in pilin biogenesis. Taken together, these data indicated that meningococci utilize multiple mechanisms including the action of the MtrC-MtrD-MtrE efflux pump and lipid A modification as well as the type IV pilin secretion system to modulate levels of CAMP resistance. The modification of meningococcal lipid A head groups with PEA also prevents neutralization of the biological effects of endotoxin by CAMP." @default.
• W2151276427 created "2016-06-24" @default.
• W2151276427 creator A5001263618 @default.
• W2151276427 creator A5018104424 @default.
• W2151276427 creator A5033478784 @default.
• W2151276427 creator A5061638194 @default.
• W2151276427 creator A5063670409 @default.
• W2151276427 creator A5068081716 @default.
• W2151276427 creator A5087754233 @default.
• W2151276427 date "2005-08-01" @default.
• W2151276427 modified "2023-10-16" @default.
• W2151276427 title "Cationic Antimicrobial Peptide Resistance in <i>Neisseria meningitidis</i>" @default.
• W2151276427 cites W1488987043 @default.
• W2151276427 cites W1498580352 @default.
• W2151276427 cites W1578768687 @default.
• W2151276427 cites W1762145425 @default.
• W2151276427 cites W1764225276 @default.
• W2151276427 cites W1881058623 @default.
• W2151276427 cites W1921818371 @default.
• W2151276427 cites W1922098314 @default.
• W2151276427 cites W1927502485 @default.
• W2151276427 cites W1937514773 @default.
• W2151276427 cites W1952034282 @default.
• W2151276427 cites W1964447229 @default.
• W2151276427 cites W1965184554 @default.
• W2151276427 cites W1967164846 @default.
• W2151276427 cites W1975085160 @default.
• W2151276427 cites W1990949770 @default.
• W2151276427 cites W1992839913 @default.
• W2151276427 cites W1993513102 @default.
• W2151276427 cites W1996901586 @default.
• W2151276427 cites W1997168562 @default.
• W2151276427 cites W2003112779 @default.
• W2151276427 cites W2009032652 @default.
• W2151276427 cites W2027007190 @default.
• W2151276427 cites W2032713569 @default.
• W2151276427 cites W2055567678 @default.
• W2151276427 cites W2072494970 @default.
• W2151276427 cites W2075700156 @default.
• W2151276427 cites W2078778780 @default.
• W2151276427 cites W2080885816 @default.
• W2151276427 cites W2082919450 @default.
• W2151276427 cites W2085787795 @default.
• W2151276427 cites W2089600467 @default.
• W2151276427 cites W2090664858 @default.
• W2151276427 cites W2091120384 @default.
• W2151276427 cites W2091513339 @default.
• W2151276427 cites W2094741750 @default.
• W2151276427 cites W2097705352 @default.
• W2151276427 cites W2098786490 @default.
• W2151276427 cites W2099965286 @default.
• W2151276427 cites W2102484565 @default.
• W2151276427 cites W2104079300 @default.
• W2151276427 cites W2113410040 @default.
• W2151276427 cites W2115996594 @default.
• W2151276427 cites W2116541052 @default.
• W2151276427 cites W2121120923 @default.
• W2151276427 cites W2121865329 @default.
• W2151276427 cites W2127335580 @default.
• W2151276427 cites W2128931069 @default.
• W2151276427 cites W2130272389 @default.
• W2151276427 cites W2131192673 @default.
• W2151276427 cites W2134564388 @default.
• W2151276427 cites W2137081432 @default.
• W2151276427 cites W2148128286 @default.
• W2151276427 cites W2151637219 @default.
• W2151276427 cites W2152831268 @default.
• W2151276427 cites W2153328681 @default.
• W2151276427 cites W2154202775 @default.
• W2151276427 cites W2155627295 @default.
• W2151276427 cites W2155812349 @default.
• W2151276427 cites W2160043086 @default.
• W2151276427 cites W2160072419 @default.
• W2151276427 cites W2161767156 @default.
• W2151276427 cites W290094515 @default.
• W2151276427 cites W4234317413 @default.
• W2151276427 doi "https://doi.org/10.1128/jb.187.15.5387-5396.2005" @default.
• W2151276427 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1196002" @default.
• W2151276427 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16030233" @default.
• W2151276427 hasPublicationYear "2005" @default.
• W2151276427 type Work @default.
• W2151276427 sameAs 2151276427 @default.
• W2151276427 citedByCount "221" @default.
• W2151276427 countsByYear W21512764272012 @default.
• W2151276427 countsByYear W21512764272013 @default.
• W2151276427 countsByYear W21512764272014 @default.
• W2151276427 countsByYear W21512764272015 @default.
• W2151276427 countsByYear W21512764272016 @default.
• W2151276427 countsByYear W21512764272017 @default.
• W2151276427 countsByYear W21512764272018 @default.
• W2151276427 countsByYear W21512764272019 @default.
• W2151276427 countsByYear W21512764272020 @default.
• W2151276427 countsByYear W21512764272021 @default.
• W2151276427 countsByYear W21512764272022 @default.
• W2151276427 countsByYear W21512764272023 @default.
• W2151276427 crossrefType "journal-article" @default.
• W2151276427 hasAuthorship W2151276427A5001263618 @default.
• W2151276427 hasAuthorship W2151276427A5018104424 @default.

• next