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• W2151277992 endingPage "3022" @default.
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• W2151277992 abstract "Murine AIDS (MAIDS) is induced by a defective retrovirus that infects lymphocyte cells of the B lineage. To determine whether functional T cells are required for the infection of B cells, T-cell-deficient mice (nude, CD4 knockout, and SCII)) were infected with helper-free stocks of the MAIDS defective virus. Infection of B cells was monitored by Northern blot analysis and in situ hybridization. The C57BL/6 nude mice contained clusters of infected B cells, but less so than did the euthymic mice. In contrast, the (C57BL/6 x BALB/c)F1 nude mice harbored more infected B cells than did their euthymic littermates when maintained in a pathogen-free environment. Clusters of infected B cells were also detected in the MAIDS virus-infected CD4-/- knockout mice despite the total absence of CD4+ T cells in these mice. However, infected cells were not detected in SCID mice (deficient in mature T and B cells) inoculated with the same virus, indicating that precursor B cells are not a target of the virus in the absence of mature CD4+ T cells. These data confirm that the primary event in the development of MAIDS is the infection of relatively mature peripheral B cells and that CD4+ T cells are required to promote the expansion of these infected B cells." @default.
• W2151277992 created "2016-06-24" @default.
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• W2151277992 date "1997-04-01" @default.
• W2151277992 modified "2023-09-27" @default.
• W2151277992 title "Studies of the susceptibility of nude, CD4 knockout, and SCID mutant mice to the disease induced by the murine AIDS defective virus" @default.
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• W2151277992 doi "https://doi.org/10.1128/jvi.71.4.3013-3022.1997" @default.
• W2151277992 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/191430" @default.
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