Matches in SemOpenAlex for { <https://semopenalex.org/work/W2151342011> ?p ?o ?g. }
- W2151342011 endingPage "822" @default.
- W2151342011 startingPage "815" @default.
- W2151342011 abstract "The Amaryllidaceae alkaloid bulbispermine was derivatized to produce a small group of synthetic analogues. These, together with bulbispermine’s natural crinine-type congeners, were evaluated in vitro against a panel of cancer cell lines with various levels of resistance to pro-apoptotic stimuli. Bulbispermine, haemanthamine, and haemanthidine showed the most potent antiproliferative activities as determined by the MTT colorimetric assay. Among the synthetic bulbispermine analogues, only the C1,C2-dicarbamate derivative exhibited notable growth inhibitory properties. All active compounds were found not to discriminate between the cancer cell lines based on the apoptosis sensitivity criterion; they displayed similar potencies in both cell types, indicating that the induction of apoptosis is not the primary mechanism responsible for antiproliferative activity in this series of compounds. It was also found that bulbispermine inhibits the proliferation of glioblastoma cells through cytostatic effects, possibly arising from rigidification of the actin cytoskeleton. These findings lead us to argue that crinine-type alkaloids are potentially useful drug leads for the treatment of apoptosis-resistant cancers and glioblastoma in particular." @default.
- W2151342011 created "2016-06-24" @default.
- W2151342011 creator A5001319464 @default.
- W2151342011 creator A5009000319 @default.
- W2151342011 creator A5024205580 @default.
- W2151342011 creator A5024545053 @default.
- W2151342011 creator A5033613763 @default.
- W2151342011 creator A5040477247 @default.
- W2151342011 creator A5050210411 @default.
- W2151342011 creator A5052002042 @default.
- W2151342011 creator A5053342008 @default.
- W2151342011 creator A5058150754 @default.
- W2151342011 creator A5058939223 @default.
- W2151342011 creator A5060257534 @default.
- W2151342011 creator A5060584398 @default.
- W2151342011 creator A5065233215 @default.
- W2151342011 creator A5076658405 @default.
- W2151342011 creator A5084802244 @default.
- W2151342011 date "2012-03-02" @default.
- W2151342011 modified "2023-10-16" @default.
- W2151342011 title "Bulbispermine: A Crinine-Type Amaryllidaceae Alkaloid Exhibiting Cytostatic Activity toward Apoptosis-Resistant Glioma Cells" @default.
- W2151342011 cites W1780453311 @default.
- W2151342011 cites W1970096460 @default.
- W2151342011 cites W1970812803 @default.
- W2151342011 cites W1972465273 @default.
- W2151342011 cites W1978848130 @default.
- W2151342011 cites W1986932993 @default.
- W2151342011 cites W1988795476 @default.
- W2151342011 cites W1991393788 @default.
- W2151342011 cites W1991518223 @default.
- W2151342011 cites W1997773537 @default.
- W2151342011 cites W2001857954 @default.
- W2151342011 cites W2005234239 @default.
- W2151342011 cites W2012671411 @default.
- W2151342011 cites W2022602911 @default.
- W2151342011 cites W2023287528 @default.
- W2151342011 cites W2032319690 @default.
- W2151342011 cites W2040517816 @default.
- W2151342011 cites W2040703381 @default.
- W2151342011 cites W2050499412 @default.
- W2151342011 cites W2050529947 @default.
- W2151342011 cites W2056193241 @default.
- W2151342011 cites W2058858243 @default.
- W2151342011 cites W2061657090 @default.
- W2151342011 cites W2064789851 @default.
- W2151342011 cites W2072009964 @default.
- W2151342011 cites W2074379908 @default.
- W2151342011 cites W2077007181 @default.
- W2151342011 cites W2078883872 @default.
- W2151342011 cites W2084479512 @default.
- W2151342011 cites W2087748260 @default.
- W2151342011 cites W2088288204 @default.
- W2151342011 cites W2093216189 @default.
- W2151342011 cites W2093577483 @default.
- W2151342011 cites W2101187282 @default.
- W2151342011 cites W2113320906 @default.
- W2151342011 cites W2114918609 @default.
- W2151342011 cites W2125812255 @default.
- W2151342011 cites W2138017682 @default.
- W2151342011 cites W2171166843 @default.
- W2151342011 cites W2330446781 @default.
- W2151342011 cites W2949940523 @default.
- W2151342011 cites W4211184887 @default.
- W2151342011 doi "https://doi.org/10.1002/cmdc.201100608" @default.
- W2151342011 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3519447" @default.
- W2151342011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22389235" @default.
- W2151342011 hasPublicationYear "2012" @default.
- W2151342011 type Work @default.
- W2151342011 sameAs 2151342011 @default.
- W2151342011 citedByCount "35" @default.
- W2151342011 countsByYear W21513420112012 @default.
- W2151342011 countsByYear W21513420112013 @default.
- W2151342011 countsByYear W21513420112014 @default.
- W2151342011 countsByYear W21513420112015 @default.
- W2151342011 countsByYear W21513420112016 @default.
- W2151342011 countsByYear W21513420112017 @default.
- W2151342011 countsByYear W21513420112018 @default.
- W2151342011 countsByYear W21513420112019 @default.
- W2151342011 countsByYear W21513420112020 @default.
- W2151342011 countsByYear W21513420112021 @default.
- W2151342011 countsByYear W21513420112022 @default.
- W2151342011 countsByYear W21513420112023 @default.
- W2151342011 crossrefType "journal-article" @default.
- W2151342011 hasAuthorship W2151342011A5001319464 @default.
- W2151342011 hasAuthorship W2151342011A5009000319 @default.
- W2151342011 hasAuthorship W2151342011A5024205580 @default.
- W2151342011 hasAuthorship W2151342011A5024545053 @default.
- W2151342011 hasAuthorship W2151342011A5033613763 @default.
- W2151342011 hasAuthorship W2151342011A5040477247 @default.
- W2151342011 hasAuthorship W2151342011A5050210411 @default.
- W2151342011 hasAuthorship W2151342011A5052002042 @default.
- W2151342011 hasAuthorship W2151342011A5053342008 @default.
- W2151342011 hasAuthorship W2151342011A5058150754 @default.
- W2151342011 hasAuthorship W2151342011A5058939223 @default.
- W2151342011 hasAuthorship W2151342011A5060257534 @default.
- W2151342011 hasAuthorship W2151342011A5060584398 @default.
- W2151342011 hasAuthorship W2151342011A5065233215 @default.
- W2151342011 hasAuthorship W2151342011A5076658405 @default.