Matches in SemOpenAlex for { <https://semopenalex.org/work/W2151357092> ?p ?o ?g. }
- W2151357092 endingPage "12" @default.
- W2151357092 startingPage "2" @default.
- W2151357092 abstract "Computational drug repositioning or repurposing is a promising and efficient tool for discovering new uses from existing drugs and holds the great potential for precision medicine in the age of big data. The explosive growth of large-scale genomic and phenotypic data, as well as data of small molecular compounds with granted regulatory approval, is enabling new developments for computational repositioning. To achieve the shortest path toward new drug indications, advanced data processing and analysis strategies are critical for making sense of these heterogeneous molecular measurements. In this review, we show recent advancements in the critical areas of computational drug repositioning from multiple aspects. First, we summarize available data sources and the corresponding computational repositioning strategies. Second, we characterize the commonly used computational techniques. Third, we discuss validation strategies for repositioning studies, including both computational and experimental methods. Finally, we highlight potential opportunities and use-cases, including a few target areas such as cancers. We conclude with a brief discussion of the remaining challenges in computational drug repositioning." @default.
- W2151357092 created "2016-06-24" @default.
- W2151357092 creator A5008413649 @default.
- W2151357092 creator A5036068985 @default.
- W2151357092 creator A5067483347 @default.
- W2151357092 creator A5074284592 @default.
- W2151357092 creator A5083081872 @default.
- W2151357092 creator A5086610385 @default.
- W2151357092 date "2015-03-31" @default.
- W2151357092 modified "2023-10-06" @default.
- W2151357092 title "A survey of current trends in computational drug repositioning" @default.
- W2151357092 cites W1540810425 @default.
- W2151357092 cites W1541232310 @default.
- W2151357092 cites W1544009106 @default.
- W2151357092 cites W1894955529 @default.
- W2151357092 cites W1964670939 @default.
- W2151357092 cites W1966527984 @default.
- W2151357092 cites W1969208427 @default.
- W2151357092 cites W1974475138 @default.
- W2151357092 cites W1975441976 @default.
- W2151357092 cites W1982945330 @default.
- W2151357092 cites W1983183415 @default.
- W2151357092 cites W1984054151 @default.
- W2151357092 cites W1989590412 @default.
- W2151357092 cites W1991646180 @default.
- W2151357092 cites W1992407562 @default.
- W2151357092 cites W1995708259 @default.
- W2151357092 cites W1997338647 @default.
- W2151357092 cites W1998056319 @default.
- W2151357092 cites W2009081245 @default.
- W2151357092 cites W2012486622 @default.
- W2151357092 cites W2012978238 @default.
- W2151357092 cites W2013130010 @default.
- W2151357092 cites W2014878562 @default.
- W2151357092 cites W2016914833 @default.
- W2151357092 cites W2020132970 @default.
- W2151357092 cites W2020274161 @default.
- W2151357092 cites W2021348977 @default.
- W2151357092 cites W2021570230 @default.
- W2151357092 cites W2023947478 @default.
- W2151357092 cites W2025130434 @default.
- W2151357092 cites W2044874589 @default.
- W2151357092 cites W2047031939 @default.
- W2151357092 cites W2049825704 @default.
- W2151357092 cites W2050078980 @default.
- W2151357092 cites W2054768549 @default.
- W2151357092 cites W2063149926 @default.
- W2151357092 cites W2068153368 @default.
- W2151357092 cites W2072262468 @default.
- W2151357092 cites W2073872665 @default.
- W2151357092 cites W2076604395 @default.
- W2151357092 cites W2078720156 @default.
- W2151357092 cites W2087911044 @default.
- W2151357092 cites W2088122814 @default.
- W2151357092 cites W2088632292 @default.
- W2151357092 cites W2091155135 @default.
- W2151357092 cites W2094791588 @default.
- W2151357092 cites W2097834966 @default.
- W2151357092 cites W2098318720 @default.
- W2151357092 cites W2098653818 @default.
- W2151357092 cites W2100929382 @default.
- W2151357092 cites W2102370461 @default.
- W2151357092 cites W2105050951 @default.
- W2151357092 cites W2106210472 @default.
- W2151357092 cites W2109120098 @default.
- W2151357092 cites W2111213181 @default.
- W2151357092 cites W2112946624 @default.
- W2151357092 cites W2113072832 @default.
- W2151357092 cites W2115517051 @default.
- W2151357092 cites W2116700442 @default.
- W2151357092 cites W2119091936 @default.
- W2151357092 cites W2121604817 @default.
- W2151357092 cites W2122683221 @default.
- W2151357092 cites W2124538722 @default.
- W2151357092 cites W2124846732 @default.
- W2151357092 cites W2125789330 @default.
- W2151357092 cites W2127132032 @default.
- W2151357092 cites W2128054164 @default.
- W2151357092 cites W2129860849 @default.
- W2151357092 cites W2130007124 @default.
- W2151357092 cites W2130410032 @default.
- W2151357092 cites W2130479394 @default.
- W2151357092 cites W2131614043 @default.
- W2151357092 cites W2134954733 @default.
- W2151357092 cites W2136181737 @default.
- W2151357092 cites W2138050607 @default.
- W2151357092 cites W2138427043 @default.
- W2151357092 cites W2138512826 @default.
- W2151357092 cites W2142016317 @default.
- W2151357092 cites W2142572836 @default.
- W2151357092 cites W2144267044 @default.
- W2151357092 cites W2144866553 @default.
- W2151357092 cites W2153301032 @default.
- W2151357092 cites W2155157373 @default.
- W2151357092 cites W2160026116 @default.
- W2151357092 cites W2161771297 @default.
- W2151357092 cites W2162723974 @default.
- W2151357092 cites W2162965868 @default.