Matches in SemOpenAlex for { <https://semopenalex.org/work/W2151376718> ?p ?o ?g. }
- W2151376718 endingPage "2795" @default.
- W2151376718 startingPage "2785" @default.
- W2151376718 abstract "The transcription factor Sox4 is vital for fetal development, as Sox4(-/-) homozygotes die in utero. Sox4 mRNA is expressed in the early embryonic growth plate and is regulated by parathyroid hormone, but its function in bone modeling/remodeling is unknown. We report that Sox4(+/-) mice exhibit significantly lower bone mass (by dual-energy X-ray absorptiometry) from an early age, and fail to obtain the peak bone mass of wild-type (WT) animals. Microcomputed tomography (muCT), histomorphometry and biomechanical testing of Sox4(+/-) bones show reduced trabecular and cortical thickness, growth plate width, ultimate force and stiffness compared with WT. Bone formation rate (BFR) in 3-month-old Sox4(+/-) mice is 64% lower than in WT. Primary calvarial osteoblasts from Sox4(+/-) mice demonstrate markedly inhibited proliferation, differentiation and mineralization. In these cultures, osterix (Osx) and osteocalcin (OCN) mRNA expression was reduced, whereas Runx2 mRNA was unaffected. No functional defects were found in osteoclasts. Silencing of Sox4 by siRNA in WT osteoblasts replicated the defects observed in Sox4(+/-) cells. We demonstrate inhibited formation and altered microarchitecture of bone in Sox4(+/-) mice versus WT, without apparent defects in bone resorption. Our results implicate the transcription factor Sox4 in regulation of bone formation, by acting upstream of Osx and independent of Runx2." @default.
- W2151376718 created "2016-06-24" @default.
- W2151376718 creator A5001875881 @default.
- W2151376718 creator A5011506319 @default.
- W2151376718 creator A5011735451 @default.
- W2151376718 creator A5026504912 @default.
- W2151376718 creator A5029181574 @default.
- W2151376718 creator A5045872291 @default.
- W2151376718 creator A5048417932 @default.
- W2151376718 creator A5049624191 @default.
- W2151376718 creator A5049625129 @default.
- W2151376718 creator A5056280115 @default.
- W2151376718 creator A5072093489 @default.
- W2151376718 creator A5079642573 @default.
- W2151376718 creator A5082955580 @default.
- W2151376718 creator A5086241409 @default.
- W2151376718 creator A5087706283 @default.
- W2151376718 date "2007-08-15" @default.
- W2151376718 modified "2023-10-03" @default.
- W2151376718 title "Osteopenia, decreased bone formation and impaired osteoblast development in <i>Sox4</i> heterozygous mice" @default.
- W2151376718 cites W1572250583 @default.
- W2151376718 cites W1949372270 @default.
- W2151376718 cites W1964983194 @default.
- W2151376718 cites W1974555927 @default.
- W2151376718 cites W1981845849 @default.
- W2151376718 cites W1984673404 @default.
- W2151376718 cites W1984995716 @default.
- W2151376718 cites W1985923547 @default.
- W2151376718 cites W1988807967 @default.
- W2151376718 cites W1990853549 @default.
- W2151376718 cites W1993169282 @default.
- W2151376718 cites W1994650341 @default.
- W2151376718 cites W1997812904 @default.
- W2151376718 cites W1997899363 @default.
- W2151376718 cites W2005011653 @default.
- W2151376718 cites W2005263665 @default.
- W2151376718 cites W2005776089 @default.
- W2151376718 cites W2011655094 @default.
- W2151376718 cites W2012690390 @default.
- W2151376718 cites W2016395646 @default.
- W2151376718 cites W2017109560 @default.
- W2151376718 cites W2025305883 @default.
- W2151376718 cites W2027363930 @default.
- W2151376718 cites W2029202516 @default.
- W2151376718 cites W2034976876 @default.
- W2151376718 cites W2035559267 @default.
- W2151376718 cites W2035895262 @default.
- W2151376718 cites W2043575567 @default.
- W2151376718 cites W2056868760 @default.
- W2151376718 cites W2059814122 @default.
- W2151376718 cites W2065415889 @default.
- W2151376718 cites W2066687881 @default.
- W2151376718 cites W2070217710 @default.
- W2151376718 cites W2071108987 @default.
- W2151376718 cites W2071234903 @default.
- W2151376718 cites W2082575625 @default.
- W2151376718 cites W2084872529 @default.
- W2151376718 cites W2093395043 @default.
- W2151376718 cites W2095250826 @default.
- W2151376718 cites W2095824876 @default.
- W2151376718 cites W2102047286 @default.
- W2151376718 cites W2112263730 @default.
- W2151376718 cites W2113661425 @default.
- W2151376718 cites W2122367477 @default.
- W2151376718 cites W2126202517 @default.
- W2151376718 cites W2131486343 @default.
- W2151376718 cites W2139300012 @default.
- W2151376718 cites W2145896028 @default.
- W2151376718 cites W2146693532 @default.
- W2151376718 cites W2147844897 @default.
- W2151376718 cites W2153720415 @default.
- W2151376718 cites W2159999899 @default.
- W2151376718 cites W2160372717 @default.
- W2151376718 cites W2166265457 @default.
- W2151376718 cites W2170372671 @default.
- W2151376718 doi "https://doi.org/10.1242/jcs.003855" @default.
- W2151376718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17652162" @default.
- W2151376718 hasPublicationYear "2007" @default.
- W2151376718 type Work @default.
- W2151376718 sameAs 2151376718 @default.
- W2151376718 citedByCount "77" @default.
- W2151376718 countsByYear W21513767182012 @default.
- W2151376718 countsByYear W21513767182013 @default.
- W2151376718 countsByYear W21513767182014 @default.
- W2151376718 countsByYear W21513767182015 @default.
- W2151376718 countsByYear W21513767182016 @default.
- W2151376718 countsByYear W21513767182017 @default.
- W2151376718 countsByYear W21513767182018 @default.
- W2151376718 countsByYear W21513767182019 @default.
- W2151376718 countsByYear W21513767182020 @default.
- W2151376718 countsByYear W21513767182021 @default.
- W2151376718 countsByYear W21513767182022 @default.
- W2151376718 countsByYear W21513767182023 @default.
- W2151376718 crossrefType "journal-article" @default.
- W2151376718 hasAuthorship W2151376718A5001875881 @default.
- W2151376718 hasAuthorship W2151376718A5011506319 @default.
- W2151376718 hasAuthorship W2151376718A5011735451 @default.
- W2151376718 hasAuthorship W2151376718A5026504912 @default.