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• W2151401596 abstract "Obese people and diabetic patients are known to be high risk of colorectal cancer (CRC), suggesting need of a new preclinical animal model, by which to extensively study the diverse mechanisms, therapy and prevention. The present study aimed to determine whether experimental obese and diabetic mice produced by monosodium glutamate (MSG) treatment are susceptible to azoxymethane (AOM)-induced colon tumorigenesis using early biomarkers, aberrant crypts foci (ACF) and β-catenin-accumulated crypts (BCACs), of colorectal carcinogenesis. Male Crj:CD-1 (ICR) newborns were daily given four subcutaneous injections of MSG (2 mg/g body wt) to induce diabetes and obesity. They were then given four intraperitoneal injections of AOM (15 mg/kg body wt) or saline (0.1 ml saline/10 g body wt). Ten weeks after the last injection of AOM, the MSG-AOM mice had a significant increase in the multiplicity of BCAC (13.83 ± 7.44, P < 0.002), but not ACF (78.00 ± 11.20), when compare to the Saline-AOM mice (5.45 ± 1.86 of BCAC and 69.27 ± 8.06 of ACF). Serum biochemical profile of the MSG-treated mice with or without AOM showed hyperinsulinemia, hypercholesteremia and hyperglycemia. The mRNA expression of insulin-like growth factor-1 receptor (IGF-1R, P <0.01) was increased in the MSG-AOM mice, when compared with the mice given AOM alone. IGF-1R was immunohistochemically expressed in the BCAC, but not ACF, in the AOM-treated mice. Our findings suggest that the MSG mice are highly susceptible to AOM-induced colorectal carcinogenesis, suggesting potential utility of our MSG-AOM mice for further investigation of the possible underlying events that affect the positive association between obese/diabetes and CRC." @default.
• W2151401596 created "2016-06-24" @default.
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• W2151401596 date "2012-01-04" @default.
• W2151401596 modified "2023-10-14" @default.
• W2151401596 title "Monosodium glutamate-induced diabetic mice are susceptible to azoxymethane-induced colon tumorigenesis" @default.
• W2151401596 cites W1602514656 @default.
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• W2151401596 cites W1968159470 @default.
• W2151401596 cites W1970351511 @default.
• W2151401596 cites W1970888221 @default.
• W2151401596 cites W1972685913 @default.
• W2151401596 cites W1984390499 @default.
• W2151401596 cites W1984716297 @default.
• W2151401596 cites W1993700847 @default.
• W2151401596 cites W1996019069 @default.
• W2151401596 cites W2001078709 @default.
• W2151401596 cites W2003081264 @default.
• W2151401596 cites W2004098247 @default.
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• W2151401596 cites W2010310261 @default.
• W2151401596 cites W2012525228 @default.
• W2151401596 cites W2013932846 @default.
• W2151401596 cites W2016767122 @default.
• W2151401596 cites W2018027797 @default.
• W2151401596 cites W2018484907 @default.
• W2151401596 cites W2021494138 @default.
• W2151401596 cites W2022271344 @default.
• W2151401596 cites W2023224277 @default.
• W2151401596 cites W2030323158 @default.
• W2151401596 cites W2034498760 @default.
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• W2151401596 cites W2040267509 @default.
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• W2151401596 cites W2073975105 @default.
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• W2151401596 cites W2082712755 @default.
• W2151401596 cites W2092796179 @default.
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• W2151401596 cites W2106121337 @default.
• W2151401596 cites W2111843196 @default.
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• W2151401596 doi "https://doi.org/10.1093/carcin/bgr323" @default.
• W2151401596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22223845" @default.
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