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• W2151416134 abstract "Abstract Background Our study is to research the effect of inhibited ADAM-17 expression through the Notch pathway in renal carcinoma. Methods Immunohistochemistry and western blot were used to examine the expression of ADAM-17 protein in renal cancer tissues. Proliferation and cell invasion of 786-o cells, as well as OS-RC-2 cells, after treatment with two different inhibitors of the Notch pathway, were examined by CCK-8 assay and Transwell assay, respectively. 786-o cell apoptosis was measured using the FCM test. Results ADAM-17 was highly expressed in RCC tissues. Compared with blocking γ-secretase, a known mechanism of impairing Notch, blockade of ADAM-17 more effectively down-regulated the expressions of Notch1 and HES-1 proteins. Similarly, we found that the ADAM-17 inhibitor, Marimastat, could more efficiently reduce renal cell proliferation and invasive capacity in comparison with the γ-secretase inhibitor DAPT when used at the same dose. Similar results were obtained when apoptosis of 786-o was measured. Conclusion Compared with γ-secretase, inhibition of ADAM-17 expression more effectively inhibits Notch pathway-mediated renal cancer cell proliferation and invasion. ADAM-17 may be a new target for future treatment of renal carcinoma." @default.
• W2151416134 created "2016-06-24" @default.
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• W2151416134 date "2013-05-09" @default.
• W2151416134 modified "2023-10-14" @default.
• W2151416134 title "Inhibition of ADAM-17 more effectively down-regulates the Notch pathway than that of γ-secretase in renal carcinoma" @default.
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• W2151416134 doi "https://doi.org/10.1186/1756-9966-32-26" @default.
• W2151416134 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3662624" @default.
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