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- W2151433054 abstract "Increasing evidence suggests an important role for autocrine/paracrine prolactin in breast and prostate cancers and other disease states. Prolactin production in these extrapituitary sites is not governed by dopamine agonists, a finding that has spurred the production of prolactin receptor antagonists. This review focuses on one such antagonist, S179D prolactin, which was produced by mimicking a natural antagonist, phosphorylated prolactin. S179D prolactin is a very effective growth antagonist, partly because it inhibits signalling from unmodified prolactin and partly because it produces its own intracellular signal. This signal results in cell differentiation, cell-cycle arrest or apoptosis depending on dose, duration of treatment and cellular context. S179D prolactin is also a potent antiangiogenic and initial studies have shown it to be a potent anti-inflammatory agent. In light of these additional modes of action, it is suggested that S179D prolactin should now be more aptly referred to as a selective prolactin receptor modulator." @default.
- W2151433054 created "2016-06-24" @default.
- W2151433054 creator A5064501659 @default.
- W2151433054 date "2006-09-21" @default.
- W2151433054 modified "2023-09-26" @default.
- W2151433054 title "Therapeutic potential of S179D prolactin – from prostate cancer to angioproliferative disorders: the first selective prolactin receptor modulator" @default.
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- W2151433054 doi "https://doi.org/10.1517/13543784.15.10.1257" @default.
- W2151433054 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16989600" @default.
- W2151433054 hasPublicationYear "2006" @default.
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