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- W2151433573 abstract "This literature review summarizes the evidence on the prevalence, determinants, clinical and economic consequences of nonadherence with immunosuppressive drugs in renal transplant patients. A literature search yielded 38 articles measuring nonadherence by self-report, collateral report, assay, refill prescriptions or electronic monitoring. The weighted mean prevalence of self-reported nonadherence was 28%. Nonadherence is associated with poor clinical outcomes, contributing to 20% of late acute rejection episodes and 16% of the graft losses (weighted means). In addition, nonadherence results in lower lifetime costs because of shorter survival, yet also in a lower number of quality adjusted life years. Consistent determinants of nonadherence were younger age, social isolation, and cognitions (e.g. low self-efficacy, certain health beliefs). Determinants concerning the health care system/team seem to be under-investigated. Because the evidence summarized in this review is based on older immunosuppressive regimens, further research should focus on prevalence, determinants and consequences of nonadherence with newer immunosuppressive regimens." @default.
- W2151433573 created "2016-06-24" @default.
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- W2151433573 date "2005-10-01" @default.
- W2151433573 modified "2023-10-10" @default.
- W2151433573 title "Prevalence, consequences, and determinants of nonadherence in adult renal transplant patients: a literature review" @default.
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- W2151433573 doi "https://doi.org/10.1111/j.1432-2277.2005.00176.x" @default.
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