FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2151437047> ?p ?o ?g. }

• W2151437047 endingPage "842" @default.
• W2151437047 startingPage "833" @default.
• W2151437047 abstract "Abstract Deleted in malignant brain tumors 1 (DMBT1) is a secreted glycoprotein displaying a broad bacterial‐binding spectrum. Recent functional and genetic studies linked DMBT1 to the suppression of LPS‐induced TLR4‐mediated NF‐κB activation and to the pathogenesis of Crohn's disease. Here, we aimed at unraveling the molecular basis of its function in mucosal protection and of its broad pathogen‐binding specificity. We report that DMBT1 directly interacts with dextran sulfate sodium (DSS) and carrageenan, a structurally similar sulfated polysaccharide, which is used as a texturizer and thickener in human dietary products. However, binding of DMBT1 does not reduce the cytotoxic effects of these agents to intestinal epithelial cells in vitro . DSS and carrageenan compete for DMBT1‐mediated bacterial aggregation via interaction with its bacterial‐recognition motif. Competition and ELISA studies identify poly‐sulfated and poly‐phosphorylated structures as ligands for this recognition motif, such as heparansulfate, LPS, and lipoteichoic acid. Dose–response studies in Dmbt1 −/− and Dmbt1 +/+ mice utilizing the DSS‐induced colitis model demonstrate a differential response only to low but not to high DSS doses. We propose that DMBT1 functions as pattern‐recognition molecule for poly‐sulfated and poly‐phosphorylated ligands providing a molecular basis for its broad bacterial‐binding specificity and its inhibitory effects on LPS‐induced TLR4‐mediated NF‐κB activation." @default.
• W2151437047 created "2016-06-24" @default.
• W2151437047 creator A5000385602 @default.
• W2151437047 creator A5003603275 @default.
• W2151437047 creator A5005302376 @default.
• W2151437047 creator A5009614631 @default.
• W2151437047 creator A5011280655 @default.
• W2151437047 creator A5011687852 @default.
• W2151437047 creator A5017705083 @default.
• W2151437047 creator A5020679205 @default.
• W2151437047 creator A5025668535 @default.
• W2151437047 creator A5028374017 @default.
• W2151437047 creator A5029455151 @default.
• W2151437047 creator A5029575769 @default.
• W2151437047 creator A5031095512 @default.
• W2151437047 creator A5039200412 @default.
• W2151437047 creator A5039907821 @default.
• W2151437047 creator A5054564152 @default.
• W2151437047 creator A5059435501 @default.
• W2151437047 creator A5064168648 @default.
• W2151437047 creator A5073345578 @default.
• W2151437047 creator A5074984035 @default.
• W2151437047 creator A5075724418 @default.
• W2151437047 creator A5081978650 @default.
• W2151437047 creator A5087044906 @default.
• W2151437047 date "2009-03-01" @default.
• W2151437047 modified "2023-10-16" @default.
• W2151437047 title "DMBT1 functions as pattern‐recognition molecule for poly‐sulfated and poly‐phosphorylated ligands" @default.
• W2151437047 cites W1492384889 @default.
• W2151437047 cites W1642457845 @default.
• W2151437047 cites W1670573097 @default.
• W2151437047 cites W1678144051 @default.
• W2151437047 cites W1857870999 @default.
• W2151437047 cites W1966533356 @default.
• W2151437047 cites W1968678178 @default.
• W2151437047 cites W1970817256 @default.
• W2151437047 cites W1978566475 @default.
• W2151437047 cites W1996736315 @default.
• W2151437047 cites W2003416351 @default.
• W2151437047 cites W2015954162 @default.
• W2151437047 cites W2018542503 @default.
• W2151437047 cites W2018584013 @default.
• W2151437047 cites W2029005330 @default.
• W2151437047 cites W2033516441 @default.
• W2151437047 cites W2035959356 @default.
• W2151437047 cites W2041646961 @default.
• W2151437047 cites W2043667001 @default.
• W2151437047 cites W2045164193 @default.
• W2151437047 cites W2060773534 @default.
• W2151437047 cites W2067901126 @default.
• W2151437047 cites W2073731887 @default.
• W2151437047 cites W2074994594 @default.
• W2151437047 cites W2075583035 @default.
• W2151437047 cites W2099376515 @default.
• W2151437047 cites W2100250996 @default.
• W2151437047 cites W2107162587 @default.
• W2151437047 cites W2116034738 @default.
• W2151437047 cites W2116761160 @default.
• W2151437047 cites W2128498632 @default.
• W2151437047 cites W2133640250 @default.
• W2151437047 cites W2136502063 @default.
• W2151437047 cites W2140607695 @default.
• W2151437047 cites W2145082201 @default.
• W2151437047 cites W2152532561 @default.
• W2151437047 cites W2196240791 @default.
• W2151437047 doi "https://doi.org/10.1002/eji.200838689" @default.
• W2151437047 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19189310" @default.
• W2151437047 hasPublicationYear "2009" @default.
• W2151437047 type Work @default.
• W2151437047 sameAs 2151437047 @default.
• W2151437047 citedByCount "57" @default.
• W2151437047 countsByYear W21514370472012 @default.
• W2151437047 countsByYear W21514370472013 @default.
• W2151437047 countsByYear W21514370472015 @default.
• W2151437047 countsByYear W21514370472016 @default.
• W2151437047 countsByYear W21514370472017 @default.
• W2151437047 countsByYear W21514370472018 @default.
• W2151437047 countsByYear W21514370472019 @default.
• W2151437047 countsByYear W21514370472020 @default.
• W2151437047 countsByYear W21514370472021 @default.
• W2151437047 countsByYear W21514370472022 @default.
• W2151437047 countsByYear W21514370472023 @default.
• W2151437047 crossrefType "journal-article" @default.
• W2151437047 hasAuthorship W2151437047A5000385602 @default.
• W2151437047 hasAuthorship W2151437047A5003603275 @default.
• W2151437047 hasAuthorship W2151437047A5005302376 @default.
• W2151437047 hasAuthorship W2151437047A5009614631 @default.
• W2151437047 hasAuthorship W2151437047A5011280655 @default.
• W2151437047 hasAuthorship W2151437047A5011687852 @default.
• W2151437047 hasAuthorship W2151437047A5017705083 @default.
• W2151437047 hasAuthorship W2151437047A5020679205 @default.
• W2151437047 hasAuthorship W2151437047A5025668535 @default.
• W2151437047 hasAuthorship W2151437047A5028374017 @default.
• W2151437047 hasAuthorship W2151437047A5029455151 @default.
• W2151437047 hasAuthorship W2151437047A5029575769 @default.
• W2151437047 hasAuthorship W2151437047A5031095512 @default.
• W2151437047 hasAuthorship W2151437047A5039200412 @default.
• W2151437047 hasAuthorship W2151437047A5039907821 @default.

• next