FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2151439171> ?p ?o ?g. }

• W2151439171 endingPage "172" @default.
• W2151439171 startingPage "165" @default.
• W2151439171 abstract "Traditional biomarkers such as alanine and aspartate aminotransferase (ALT, AST) and total bilirubin (TBIL) have been widely used for detecting drug-induced liver injury (DILI). Although the Food and Drug Administration (FDA) proposed standardized thresholds for human as Hy's law, those for animals have not been determined, and predictability of these biomarkers for future onset of hepatic lesions remains unclear. In this study, we investigated these diagnostic and predictive performance of 10 traditional biomarkers for liver injury by receiver-operating characteristic (ROC) curve, using a free-access database where 142 hepatotoxic or non-hepatotoxic compounds were administrated to male rats (n=5253). Standardization of each biomarker value was achieved by calculating the ratio to control mean value, and the thresholds were determined under the condition of permitting 5% false positive. Of these 10 biomarkers, AST showed the best diagnostic performance. Furthermore, ALT and TBIL also showed high performance under the situation of hepatocellular necrosis and bile duct injury, respectively. Additionally, the availability of the diagnostic thresholds in difference testing facility was confirmed by the application of these thresholds to in-house prepared dataset. Meanwhile, incorrect diagnosis by the thresholds was also observed. Regarding prediction, all 10 biomarkers showed insufficient performance for future onset of hepatic lesions. In conclusion, the standardized diagnostic thresholds enable consistent evaluation of traditional biomarkers among different facilities, whereas it was suggested that novel biomarker is required for more accurate diagnosis and prediction of DILI." @default.
• W2151439171 created "2016-06-24" @default.
• W2151439171 creator A5014479561 @default.
• W2151439171 creator A5028399560 @default.
• W2151439171 creator A5032603959 @default.
• W2151439171 creator A5034225997 @default.
• W2151439171 creator A5042020714 @default.
• W2151439171 creator A5045893156 @default.
• W2151439171 creator A5048555266 @default.
• W2151439171 creator A5015807190 @default.
• W2151439171 date "2014-09-04" @default.
• W2151439171 modified "2023-10-05" @default.
• W2151439171 title "Diagnostic and predictive performance and standardized threshold of traditional biomarkers for drug-induced liver injury in rats" @default.
• W2151439171 cites W1991652499 @default.
• W2151439171 cites W2006617902 @default.
• W2151439171 cites W2007795329 @default.
• W2151439171 cites W2017783406 @default.
• W2151439171 cites W2022057640 @default.
• W2151439171 cites W2044498526 @default.
• W2151439171 cites W2048517328 @default.
• W2151439171 cites W2054546147 @default.
• W2151439171 cites W2061516382 @default.
• W2151439171 cites W2071147380 @default.
• W2151439171 cites W2084787228 @default.
• W2151439171 cites W2098517795 @default.
• W2151439171 cites W2100098337 @default.
• W2151439171 cites W2100414335 @default.
• W2151439171 cites W2105873772 @default.
• W2151439171 cites W2116598229 @default.
• W2151439171 cites W2132727601 @default.
• W2151439171 cites W2136484202 @default.
• W2151439171 cites W2138564414 @default.
• W2151439171 cites W2139626257 @default.
• W2151439171 cites W2140374086 @default.
• W2151439171 cites W2146367199 @default.
• W2151439171 cites W2164482170 @default.
• W2151439171 cites W2168198006 @default.
• W2151439171 cites W2278793656 @default.
• W2151439171 cites W2316475322 @default.
• W2151439171 cites W2766368224 @default.
• W2151439171 cites W4211186852 @default.
• W2151439171 doi "https://doi.org/10.1002/jat.3053" @default.
• W2151439171 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25186495" @default.
• W2151439171 hasPublicationYear "2014" @default.
• W2151439171 type Work @default.
• W2151439171 sameAs 2151439171 @default.
• W2151439171 citedByCount "9" @default.
• W2151439171 countsByYear W21514391712016 @default.
• W2151439171 countsByYear W21514391712018 @default.
• W2151439171 countsByYear W21514391712019 @default.
• W2151439171 countsByYear W21514391712020 @default.
• W2151439171 countsByYear W21514391712022 @default.
• W2151439171 countsByYear W21514391712023 @default.
• W2151439171 crossrefType "journal-article" @default.
• W2151439171 hasAuthorship W2151439171A5014479561 @default.
• W2151439171 hasAuthorship W2151439171A5015807190 @default.
• W2151439171 hasAuthorship W2151439171A5028399560 @default.
• W2151439171 hasAuthorship W2151439171A5032603959 @default.
• W2151439171 hasAuthorship W2151439171A5034225997 @default.
• W2151439171 hasAuthorship W2151439171A5042020714 @default.
• W2151439171 hasAuthorship W2151439171A5045893156 @default.
• W2151439171 hasAuthorship W2151439171A5048555266 @default.
• W2151439171 hasConcept C126322002 @default.
• W2151439171 hasConcept C142724271 @default.
• W2151439171 hasConcept C198433322 @default.
• W2151439171 hasConcept C2776637226 @default.
• W2151439171 hasConcept C2780035454 @default.
• W2151439171 hasConcept C2781197716 @default.
• W2151439171 hasConcept C2992872382 @default.
• W2151439171 hasConcept C3019719930 @default.
• W2151439171 hasConcept C55493867 @default.
• W2151439171 hasConcept C58471807 @default.
• W2151439171 hasConcept C71924100 @default.
• W2151439171 hasConcept C76318530 @default.
• W2151439171 hasConcept C86803240 @default.
• W2151439171 hasConcept C90924648 @default.
• W2151439171 hasConcept C98274493 @default.
• W2151439171 hasConceptScore W2151439171C126322002 @default.
• W2151439171 hasConceptScore W2151439171C142724271 @default.
• W2151439171 hasConceptScore W2151439171C198433322 @default.
• W2151439171 hasConceptScore W2151439171C2776637226 @default.
• W2151439171 hasConceptScore W2151439171C2780035454 @default.
• W2151439171 hasConceptScore W2151439171C2781197716 @default.
• W2151439171 hasConceptScore W2151439171C2992872382 @default.
• W2151439171 hasConceptScore W2151439171C3019719930 @default.
• W2151439171 hasConceptScore W2151439171C55493867 @default.
• W2151439171 hasConceptScore W2151439171C58471807 @default.
• W2151439171 hasConceptScore W2151439171C71924100 @default.
• W2151439171 hasConceptScore W2151439171C76318530 @default.
• W2151439171 hasConceptScore W2151439171C86803240 @default.
• W2151439171 hasConceptScore W2151439171C90924648 @default.
• W2151439171 hasConceptScore W2151439171C98274493 @default.
• W2151439171 hasIssue "2" @default.
• W2151439171 hasLocation W21514391711 @default.
• W2151439171 hasLocation W21514391712 @default.
• W2151439171 hasOpenAccess W2151439171 @default.
• W2151439171 hasPrimaryLocation W21514391711 @default.
• W2151439171 hasRelatedWork W2003480102 @default.

• next