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- W2151444080 endingPage "1113" @default.
- W2151444080 startingPage "1102" @default.
- W2151444080 abstract "Extracellular matrix-degrading matrix metalloproteinases (MMPs) are invariably upregulated in epithelial cancers and are key agonists in angiogenesis, invasion and metastasis. Yet most MMPs are secreted not by the cancer cells themselves, but by stromal cells within and around the tumor mass. Because the stromal environment can influence tumor formation, and because MMPs can alter this environment, MMPs may also contribute to the initial stages of cancer development. Several recent studies in MMP-overexpressing and MMP-deficient mice support this possibility, but have required carcinogens or pre-existing oncogenic mutations to initiate tumorigenesis. Here we review the spontaneous development of premalignant and malignant lesions in the mammary glands of transgenic mice that express an autoactivating form of MMP-3/stromelysin-1 under the control of the whey acidic protein gene promoter. These changes were absent in nontransgenic littermates and were quenched by co-expression of a human tissue inhibitor of metalloproteinases-1 (TIMP-1) transgene. Thus by altering the cellular microenvironment, stromelysin-1 can act as a natural tumor promoter and enhance cancer susceptibility." @default.
- W2151444080 created "2016-06-24" @default.
- W2151444080 creator A5014951457 @default.
- W2151444080 creator A5048523154 @default.
- W2151444080 creator A5072917052 @default.
- W2151444080 date "2000-02-21" @default.
- W2151444080 modified "2023-09-28" @default.
- W2151444080 title "The matrix metalloproteinase stromelysin-1 acts as a natural mammary tumor promoter" @default.
- W2151444080 cites W109911703 @default.
- W2151444080 cites W131959092 @default.
- W2151444080 cites W1425979353 @default.
- W2151444080 cites W1485071570 @default.
- W2151444080 cites W1485817058 @default.
- W2151444080 cites W1488099175 @default.
- W2151444080 cites W1507249104 @default.
- W2151444080 cites W1536317083 @default.
- W2151444080 cites W1542132697 @default.
- W2151444080 cites W1554815317 @default.
- W2151444080 cites W1559508265 @default.
- W2151444080 cites W1562667342 @default.
- W2151444080 cites W1564770156 @default.
- W2151444080 cites W1598750225 @default.
- W2151444080 cites W1602004990 @default.
- W2151444080 cites W1650984530 @default.
- W2151444080 cites W1834589661 @default.
- W2151444080 cites W1856825071 @default.
- W2151444080 cites W1917407704 @default.
- W2151444080 cites W1939368710 @default.
- W2151444080 cites W1967123206 @default.
- W2151444080 cites W1973002991 @default.
- W2151444080 cites W1973046279 @default.
- W2151444080 cites W1973285844 @default.
- W2151444080 cites W1973318102 @default.
- W2151444080 cites W1976831807 @default.
- W2151444080 cites W1978680709 @default.
- W2151444080 cites W1983219998 @default.
- W2151444080 cites W1986612792 @default.
- W2151444080 cites W1988784463 @default.
- W2151444080 cites W1989963027 @default.
- W2151444080 cites W1995033273 @default.
- W2151444080 cites W1995862211 @default.
- W2151444080 cites W1997510672 @default.
- W2151444080 cites W1997522892 @default.
- W2151444080 cites W1999225211 @default.
- W2151444080 cites W2000903132 @default.
- W2151444080 cites W2002404925 @default.
- W2151444080 cites W2005088732 @default.
- W2151444080 cites W2009168769 @default.
- W2151444080 cites W2011111584 @default.
- W2151444080 cites W2012104993 @default.
- W2151444080 cites W2015809080 @default.
- W2151444080 cites W2016411107 @default.
- W2151444080 cites W2016538599 @default.
- W2151444080 cites W2021122530 @default.
- W2151444080 cites W2022704877 @default.
- W2151444080 cites W2022718682 @default.
- W2151444080 cites W2022896763 @default.
- W2151444080 cites W2025500658 @default.
- W2151444080 cites W2033658747 @default.
- W2151444080 cites W2035155128 @default.
- W2151444080 cites W2035548685 @default.
- W2151444080 cites W2036797845 @default.
- W2151444080 cites W2037910534 @default.
- W2151444080 cites W2055298771 @default.
- W2151444080 cites W2058703787 @default.
- W2151444080 cites W2063960633 @default.
- W2151444080 cites W2067192296 @default.
- W2151444080 cites W2070412924 @default.
- W2151444080 cites W2073134023 @default.
- W2151444080 cites W2077483002 @default.
- W2151444080 cites W2077904476 @default.
- W2151444080 cites W2077978159 @default.
- W2151444080 cites W2078502999 @default.
- W2151444080 cites W2083214244 @default.
- W2151444080 cites W2083487959 @default.
- W2151444080 cites W2093101935 @default.
- W2151444080 cites W2096353669 @default.
- W2151444080 cites W2102303842 @default.
- W2151444080 cites W2109296642 @default.
- W2151444080 cites W2110173413 @default.
- W2151444080 cites W2117661585 @default.
- W2151444080 cites W2117733417 @default.
- W2151444080 cites W2127820506 @default.
- W2151444080 cites W2129668825 @default.
- W2151444080 cites W2134976853 @default.
- W2151444080 cites W2137008427 @default.
- W2151444080 cites W2143324424 @default.
- W2151444080 cites W2143411821 @default.
- W2151444080 cites W2145704374 @default.
- W2151444080 cites W2146440075 @default.
- W2151444080 cites W2148130479 @default.
- W2151444080 cites W2153188915 @default.
- W2151444080 cites W2154712214 @default.
- W2151444080 cites W2160787256 @default.
- W2151444080 cites W2161940923 @default.
- W2151444080 cites W2167869180 @default.
- W2151444080 cites W2188357563 @default.
- W2151444080 cites W2276640105 @default.