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• W2151444334 endingPage "1186" @default.
• W2151444334 startingPage "1176" @default.
• W2151444334 abstract "Treatment with the microsomal enzyme inducer <i>trans</i>-stilbene oxide (TSO) can decrease biliary excretion of acetaminophen-glucuronide (AA-GLUC) and increase efflux of AA-GLUC into blood. The hepatic canalicular multidrug resistance protein (Mrp) 2 and sinusoidal protein Mrp3 transport AA-GLUC conjugates into bile and blood, respectively. Thus, TSO-induced alterations in the vectorial excretion of AA-GLUC may occur via increased hepatic Mrp3 levels. The goal of this study was to determine whether TSO, diallyl sulfide (DAS), and oltipraz (OLT) treatments can up-regulate Mrp3 protein expression, and whether treatment with DAS and OLT can correspondingly increase hepatovascular efflux of AA metabolites. Rats were administered phenobarbital, TSO, DAS, OLT, or vehicle for 4 days. Interestingly, all of the chemicals increased the plasma concentration and urinary excretion of AA-GLUC and decreased its biliary excretion. In control animals, approximately 77% and 23% of AA-GLUC was excreted into bile or urine, respectively, whereas with inducer-pretreated animals, <32% of AA-GLUC was excreted into bile and >68% was excreted into urine. Correspondingly, all of the compounds increased hepatic Mrp3 mRNA levels by 13- to 37-fold and protein levels by 2- to 6-fold, respectively. In conclusion, these studies correlate increased Mrp3 protein levels in liver with increased hepatovascular excretion of AA-GLUC and suggest that induction of Mrp3 affects the route of drug excretion." @default.
• W2151444334 created "2016-06-24" @default.
• W2151444334 creator A5013133268 @default.
• W2151444334 creator A5019500582 @default.
• W2151444334 creator A5046103700 @default.
• W2151444334 creator A5076743166 @default.
• W2151444334 date "2003-08-14" @default.
• W2151444334 modified "2023-09-27" @default.
• W2151444334 title "INDUCTION OF MULTIDRUG RESISTANCE PROTEIN 3 IN RAT LIVER IS ASSOCIATED WITH ALTERED VECTORIAL EXCRETION OF ACETAMINOPHEN METABOLITES" @default.
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• W2151444334 doi "https://doi.org/10.1124/dmd.31.9.1176" @default.
• W2151444334 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12920174" @default.
• W2151444334 hasPublicationYear "2003" @default.
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