Matches in SemOpenAlex for { <https://semopenalex.org/work/W2151444462> ?p ?o ?g. }
- W2151444462 endingPage "2433" @default.
- W2151444462 startingPage "2423" @default.
- W2151444462 abstract "Human DNA polymerase and DNA ligase utilization for the repair of a major class of ionizing radiation-induced DNA lesion [DNA single-strand breaks containing 3′-phosphoglycolate (3′-PG)] was examined using a novel, chemically defined vector substrate containing a single, site-specific 3′-PG single-strand break lesion. In addition, the major human AP endonuclease, HAP1 (also known as APE1, APEX, Ref-1), was tested to determine if it was involved in initiating repair of 3′-PG-containing single-strand break lesions. DNA polymerase β was found to be the primary polymerase responsible for nucleotide incorporation at the lesion site following excision of the 3′-PG blocking group. However, DNA polymerase δ/ε was also capable of nucleotide incorporation at the lesion site following 3′-PG excision. In addition, repair reactions catalyzed by DNA polymerase β were found to be most effective in the presence of DNA ligase III, while those catalyzed by DNA polymerase δ/ε appeared to be more effective in the presence of DNA ligase I. Also, it was demonstrated that the repair initiating 3′-PG excision reaction was not dependent upon HAP1 activity, as judged by inhibition of HAP1 with neutralizing HAP1-specific polyclonal antibody." @default.
- W2151444462 created "2016-06-24" @default.
- W2151444462 creator A5007842122 @default.
- W2151444462 creator A5032374004 @default.
- W2151444462 creator A5056579080 @default.
- W2151444462 creator A5058528594 @default.
- W2151444462 creator A5065146865 @default.
- W2151444462 creator A5079978565 @default.
- W2151444462 date "1999-01-01" @default.
- W2151444462 modified "2023-09-26" @default.
- W2151444462 title "Determination of human DNA polymerase utilization for the repair of a model ionizing radiation-induced DNA strand break lesion in a defined vector substrate" @default.
- W2151444462 cites W1512703420 @default.
- W2151444462 cites W1545021361 @default.
- W2151444462 cites W1548528866 @default.
- W2151444462 cites W1785654530 @default.
- W2151444462 cites W1813018425 @default.
- W2151444462 cites W1932728046 @default.
- W2151444462 cites W1949973946 @default.
- W2151444462 cites W1956055380 @default.
- W2151444462 cites W1969149902 @default.
- W2151444462 cites W1971602039 @default.
- W2151444462 cites W1974823582 @default.
- W2151444462 cites W1979116667 @default.
- W2151444462 cites W1985680698 @default.
- W2151444462 cites W1986444835 @default.
- W2151444462 cites W1993771611 @default.
- W2151444462 cites W1996202279 @default.
- W2151444462 cites W1999053983 @default.
- W2151444462 cites W2000479074 @default.
- W2151444462 cites W2009528280 @default.
- W2151444462 cites W2011970141 @default.
- W2151444462 cites W2012291005 @default.
- W2151444462 cites W2012579169 @default.
- W2151444462 cites W2013210712 @default.
- W2151444462 cites W2020540440 @default.
- W2151444462 cites W2020633581 @default.
- W2151444462 cites W2023138072 @default.
- W2151444462 cites W2028699975 @default.
- W2151444462 cites W2034489354 @default.
- W2151444462 cites W2035932182 @default.
- W2151444462 cites W2040825860 @default.
- W2151444462 cites W2042699531 @default.
- W2151444462 cites W2044064237 @default.
- W2151444462 cites W2044461915 @default.
- W2151444462 cites W2045899523 @default.
- W2151444462 cites W2054759478 @default.
- W2151444462 cites W2064538331 @default.
- W2151444462 cites W2074598863 @default.
- W2151444462 cites W2077634990 @default.
- W2151444462 cites W2080982746 @default.
- W2151444462 cites W2083226099 @default.
- W2151444462 cites W2087266870 @default.
- W2151444462 cites W2094885536 @default.
- W2151444462 cites W2095369054 @default.
- W2151444462 cites W2097632872 @default.
- W2151444462 cites W2101108802 @default.
- W2151444462 cites W2105908798 @default.
- W2151444462 cites W2114539716 @default.
- W2151444462 cites W2118764522 @default.
- W2151444462 cites W2118970748 @default.
- W2151444462 cites W2135890914 @default.
- W2151444462 cites W2144036101 @default.
- W2151444462 cites W2145238731 @default.
- W2151444462 cites W2147192624 @default.
- W2151444462 cites W2149922717 @default.
- W2151444462 cites W2150281047 @default.
- W2151444462 cites W2154690470 @default.
- W2151444462 cites W2398980959 @default.
- W2151444462 cites W4295010936 @default.
- W2151444462 doi "https://doi.org/10.1093/nar/27.11.2423" @default.
- W2151444462 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/148811" @default.
- W2151444462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10325434" @default.
- W2151444462 hasPublicationYear "1999" @default.
- W2151444462 type Work @default.
- W2151444462 sameAs 2151444462 @default.
- W2151444462 citedByCount "32" @default.
- W2151444462 countsByYear W21514444622012 @default.
- W2151444462 countsByYear W21514444622013 @default.
- W2151444462 countsByYear W21514444622014 @default.
- W2151444462 crossrefType "journal-article" @default.
- W2151444462 hasAuthorship W2151444462A5007842122 @default.
- W2151444462 hasAuthorship W2151444462A5032374004 @default.
- W2151444462 hasAuthorship W2151444462A5056579080 @default.
- W2151444462 hasAuthorship W2151444462A5058528594 @default.
- W2151444462 hasAuthorship W2151444462A5065146865 @default.
- W2151444462 hasAuthorship W2151444462A5079978565 @default.
- W2151444462 hasBestOaLocation W21514444621 @default.
- W2151444462 hasConcept C104317684 @default.
- W2151444462 hasConcept C104451858 @default.
- W2151444462 hasConcept C116988904 @default.
- W2151444462 hasConcept C134935766 @default.
- W2151444462 hasConcept C153911025 @default.
- W2151444462 hasConcept C156719811 @default.
- W2151444462 hasConcept C164965036 @default.
- W2151444462 hasConcept C175114707 @default.
- W2151444462 hasConcept C2756471 @default.
- W2151444462 hasConcept C31254050 @default.
- W2151444462 hasConcept C49105822 @default.