FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2151474580> ?p ?o ?g. }

• W2151474580 endingPage "755" @default.
• W2151474580 startingPage "746" @default.
• W2151474580 abstract "We recently described a pro-inflammatory gene expression signature in the monocytes of 60% of patients with recent-onset schizophrenia (SCZ). Here we investigated whether the T-cell system is also in a pro-inflammatory state. A detailed fluorescence-activated cell sorting (FACS) analysis, e.g. of CD3+CD25+ T cells, IFN-γ+, IL-4+, IL-17A+ (CD4+) lymphocytes and CD4+CD25highFoxP3+ regulatory T cells, was performed on peripheral blood of 26 patients with recent-onset SCZ (in 19 of whom the inflammatory gene expression signature of the monocyte had been determined) and in age-/gender-matched healthy controls. Various relevant T-cell cytokines, e.g. sCD25, IFN-γ, IL-17A and IL-4, were measured in serum by a multiplex assay. We detected: (a) not only higher percentages of pro-inflammatory-prone monocytes, activated CD3+CD25+ T cells and pro-inflammatory Th17 cells in patients, but also higher percentages of anti-inflammatory CD4+CD25highFoxP3+ regulatory T cells and IL-4+ lymphocytes; (b) that this activated T-cell set point was reflected in significantly raised serum levels of sCD25; (c) that the up-regulation of IL-4+-containing lymphocytes was predominantly found in patients characterized by a monocyte pro-inflammatory set point; and (d) that regulatory T-cell and Th17-cell numbers were higher in patients irrespective of the pro-inflammatory state of the monocytes. Our data do not support the concept that the T-cell system is in a simple pro-inflammatory state in recent-onset SCZ, but do show that the monocyte and T-cell networks are activated and involve both pro- and anti-inflammatory forces. This suggests control within an activated inflammatory system." @default.
• W2151474580 created "2016-06-24" @default.
• W2151474580 creator A5006234724 @default.
• W2151474580 creator A5029577440 @default.
• W2151474580 creator A5041793132 @default.
• W2151474580 creator A5050910328 @default.
• W2151474580 creator A5064181236 @default.
• W2151474580 creator A5083484576 @default.
• W2151474580 creator A5090875089 @default.
• W2151474580 date "2011-07-01" @default.
• W2151474580 modified "2023-10-11" @default.
• W2151474580 title "An activated set point of T-cell and monocyte inflammatory networks in recent-onset schizophrenia patients involves both pro- and anti-inflammatory forces" @default.
• W2151474580 cites W1833987578 @default.
• W2151474580 cites W1987717262 @default.
• W2151474580 cites W2002726823 @default.
• W2151474580 cites W2011914193 @default.
• W2151474580 cites W2012114706 @default.
• W2151474580 cites W2016086434 @default.
• W2151474580 cites W2018851857 @default.
• W2151474580 cites W2019410645 @default.
• W2151474580 cites W2020444377 @default.
• W2151474580 cites W2026728307 @default.
• W2151474580 cites W2043044540 @default.
• W2151474580 cites W2045067545 @default.
• W2151474580 cites W2048776176 @default.
• W2151474580 cites W2049372707 @default.
• W2151474580 cites W2050179923 @default.
• W2151474580 cites W2053327244 @default.
• W2151474580 cites W2072328883 @default.
• W2151474580 cites W2082162853 @default.
• W2151474580 cites W2082858693 @default.
• W2151474580 cites W2086595653 @default.
• W2151474580 cites W2090350179 @default.
• W2151474580 cites W2092577598 @default.
• W2151474580 cites W2093705034 @default.
• W2151474580 cites W2116134423 @default.
• W2151474580 cites W2149368476 @default.
• W2151474580 cites W2159252214 @default.
• W2151474580 cites W2159838806 @default.
• W2151474580 cites W2166725781 @default.
• W2151474580 doi "https://doi.org/10.1017/s1461145710001653" @default.
• W2151474580 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21255481" @default.
• W2151474580 hasPublicationYear "2011" @default.
• W2151474580 type Work @default.
• W2151474580 sameAs 2151474580 @default.
• W2151474580 citedByCount "132" @default.
• W2151474580 countsByYear W21514745802012 @default.
• W2151474580 countsByYear W21514745802013 @default.
• W2151474580 countsByYear W21514745802014 @default.
• W2151474580 countsByYear W21514745802015 @default.
• W2151474580 countsByYear W21514745802016 @default.
• W2151474580 countsByYear W21514745802017 @default.
• W2151474580 countsByYear W21514745802018 @default.
• W2151474580 countsByYear W21514745802019 @default.
• W2151474580 countsByYear W21514745802020 @default.
• W2151474580 countsByYear W21514745802021 @default.
• W2151474580 countsByYear W21514745802022 @default.
• W2151474580 countsByYear W21514745802023 @default.
• W2151474580 crossrefType "journal-article" @default.
• W2151474580 hasAuthorship W2151474580A5006234724 @default.
• W2151474580 hasAuthorship W2151474580A5029577440 @default.
• W2151474580 hasAuthorship W2151474580A5041793132 @default.
• W2151474580 hasAuthorship W2151474580A5050910328 @default.
• W2151474580 hasAuthorship W2151474580A5064181236 @default.
• W2151474580 hasAuthorship W2151474580A5083484576 @default.
• W2151474580 hasAuthorship W2151474580A5090875089 @default.
• W2151474580 hasBestOaLocation W21514745802 @default.
• W2151474580 hasConcept C1491633281 @default.
• W2151474580 hasConcept C203014093 @default.
• W2151474580 hasConcept C2776090121 @default.
• W2151474580 hasConcept C2776914184 @default.
• W2151474580 hasConcept C2778630268 @default.
• W2151474580 hasConcept C2781184567 @default.
• W2151474580 hasConcept C54355233 @default.
• W2151474580 hasConcept C553184892 @default.
• W2151474580 hasConcept C71924100 @default.
• W2151474580 hasConcept C79484868 @default.
• W2151474580 hasConcept C86803240 @default.
• W2151474580 hasConcept C8891405 @default.
• W2151474580 hasConceptScore W2151474580C1491633281 @default.
• W2151474580 hasConceptScore W2151474580C203014093 @default.
• W2151474580 hasConceptScore W2151474580C2776090121 @default.
• W2151474580 hasConceptScore W2151474580C2776914184 @default.
• W2151474580 hasConceptScore W2151474580C2778630268 @default.
• W2151474580 hasConceptScore W2151474580C2781184567 @default.
• W2151474580 hasConceptScore W2151474580C54355233 @default.
• W2151474580 hasConceptScore W2151474580C553184892 @default.
• W2151474580 hasConceptScore W2151474580C71924100 @default.
• W2151474580 hasConceptScore W2151474580C79484868 @default.
• W2151474580 hasConceptScore W2151474580C86803240 @default.
• W2151474580 hasConceptScore W2151474580C8891405 @default.
• W2151474580 hasIssue "6" @default.
• W2151474580 hasLocation W21514745801 @default.
• W2151474580 hasLocation W21514745802 @default.
• W2151474580 hasLocation W21514745803 @default.
• W2151474580 hasLocation W21514745804 @default.
• W2151474580 hasOpenAccess W2151474580 @default.
• W2151474580 hasPrimaryLocation W21514745801 @default.

• next