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• W2151482983 abstract "The involvement of nitric oxide (NO), cyclic GMP and ATP-sensitive K+ channels in the antinociceptive effect of ketorolac was assessed using the formalin test in the rat. Local administration of ketorolac in a formalin-injured paw produced a dose-dependent antinociceptive effect due to a local action, as drug administration in the contralateral paw was ineffective. Pretreatment of the injured paw with NG-l-nitro-arginine methyl ester (l-NAME, an NO synthesis inhibitor), 1H-(1,2,4)-oxadiazolo(4,2-a)quinoxalin-1-one (ODQ, a soluble guanylyl cyclase inhibitor) or glibenclamide (an ATP-sensitive K+ channel blocker) prevented ketorolac-induced antinociception. However, pretreatment with saline or NG-d-nitro-arginine methyl ester (d-NAME) did not block antinociception. Local administration of S-nitroso-N-acetylpenicillamine (SNAP, an NO donor) was inactive by itself, but increased the effect of ketorolac. The present results suggest that the antinociceptive effect of ketorolac involves activation of the NO–cyclic GMP pathway, followed by an opening of ATP-sensitive K+ channels at the peripheral level." @default.
• W2151482983 created "2016-06-24" @default.
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• W2151482983 date "2001-08-01" @default.
• W2151482983 modified "2023-10-18" @default.
• W2151482983 title "Participation of the nitric oxide–cyclic GMP–ATP-sensitive K+ channel pathway in the antinociceptive action of ketorolac" @default.
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• W2151482983 doi "https://doi.org/10.1016/s0014-2999(01)01206-7" @default.
• W2151482983 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11525769" @default.
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