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- W2151494919 endingPage "361" @default.
- W2151494919 startingPage "339" @default.
- W2151494919 abstract "Most facets of mammalian physiology and behavior vary according to time of day, thanks to endogenous circadian clocks. Therefore, it is not surprising that many aspects of pharmacology and toxicology also oscillate according to the same 24-h clocks. Daily oscillations in abundance of proteins necessary for either drug absorption or metabolism result in circadian pharmacokinetics, and oscillations in the physiological systems targeted by these drugs result in circadian pharmacodynamics. These clocks are present in most cells of the body, organized in a hierarchical fashion. Interestingly, some aspects of physiology and behavior are controlled directly via a “master clock” in the suprachiasmatic nuclei of the hypothalamus, whereas others are controlled by “slave” oscillators in separate brain regions or body tissues. Recent research shows that these clocks can respond to different cues and thereby show different phase relationships. Therefore, full prediction of chronopharmacology in pathological contexts will likely require a systems biology approach that considers chronointeractions among different clock-regulated systems." @default.
- W2151494919 created "2016-06-24" @default.
- W2151494919 creator A5019327202 @default.
- W2151494919 creator A5042822389 @default.
- W2151494919 creator A5048468194 @default.
- W2151494919 date "2014-01-06" @default.
- W2151494919 modified "2023-09-24" @default.
- W2151494919 title "Chronopharmacology: New Insights and Therapeutic Implications" @default.
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