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• W2151495377 abstract "Formation of the fusion pore is a central question for regulated exocytosis by which secretory cells release neurotransmitters or hormones. Here, by dynamically monitoring exocytosis of large vesicles (2-7 μM) in astrocytes with two-photon microscopy imaging, we found that the exocytotic fusion pore was generated from the SNARE-dependent fusion at a ring shape of the docked plasma-vesicular membrane and the movement of a fusion-produced membrane fragment. We observed two modes of fragment movements, 1) a shift fragment that shifted to expand the fusion pore and 2) a fall-in fragment that fell into the collapsed vesicle to expand the fusion pore. Shift and fall-in modes are associated with full and partial collapses of large vesicles, respectively. The astrocytic marker, sulforhodamine 101, stained the fusion-produced membrane fragment more brightly than FM 1-43. Sulforhodamine 101 imaging showed that double fusion pores could simultaneously occur in a single vesicle (16% of large vesicles) to accelerate discharge of vesicular contents. Electron microscopy of large astrocytic vesicles showed shift and fall-in membrane fragments. Two modes of fusion pore formation demonstrate a novel mechanism underlying fusion pore expansion and provide a new explanation for full and partial collapses of large secretory vesicles." @default.
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• W2151495377 date "2013-06-01" @default.
• W2151495377 modified "2023-09-26" @default.
• W2151495377 title "Two Distinct Modes of Exocytotic Fusion Pore Expansion in Large Astrocytic Vesicles" @default.
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• W2151495377 doi "https://doi.org/10.1074/jbc.m113.468231" @default.
• W2151495377 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3675620" @default.
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• W2151495377 hasPublicationYear "2013" @default.
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