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• W2151508785 abstract "No AccessJournal of UrologyClinical Urology: Original Article1 Jan 1997Diagnostic Accuracy of Ureteroscopic Biopsy in Upper Tract Transitional Cell Carcinoma Francis X. Keeley, Deborah A. Kulp, Marluce Bibbo, Peter A. McCue, and Demetrius H. Bagley Francis X. KeeleyFrancis X. Keeley More articles by this author , Deborah A. KulpDeborah A. Kulp More articles by this author , Marluce BibboMarluce Bibbo More articles by this author , Peter A. McCuePeter A. McCue More articles by this author , and Demetrius H. BagleyDemetrius H. Bagley More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)65273-XAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Our aim was to determine the accuracy of ureteroscopic biopsies and cytological techniques compared to open surgical specimens of upper tract transitional cell carcinoma. Materials and Methods: From 1985 to 1995, 51 cases of upper tract transitional cell carcinoma were diagnosed ureteroscopically and distal ureterectomy or nephroureterectomy was performed. Each patient underwent direct ureteroscopic inspection and biopsy. Fresh samples were delivered to the cytopathology laboratory, where they were examined using cytospin and smear. A cell block was prepared when visible tissue was present. Grades of ureteroscopic biopsies were compared to grades and stages of surgical specimens in 42 cases. Results: Cytological evaluation was positive for malignancy in 48 of the 51 cases (94.1%). Grading of ureteroscopic specimens was possible in 42 cases (82.4%). Transitional cell carcinoma grade on ureteroscopy accurately predicted tumor grade and stage in the surgical specimens. Of 30 low or moderate grade ureteroscopic specimens 27 (90%) proved to be low or moderate grade transitional cell carcinoma in the surgical specimens, while 11 of the 12 high grade ureteroscopic specimens (91.6%) proved to be high grade transitional cell carcinoma (p <0.0001). Of 30 low or moderate grade ureteroscopic specimens 26 (86.6%) had a low stage (Ta or T1) tumor. In contrast, 8 of 12 high grade ureteroscopic specimens (66.7%) had invasive tumor (stage T2 or T3) in the surgical specimen (p = 0.0006). Conclusions: Ureteroscopic inspection and biopsy combined with cytological techniques provide accurate information regarding grade and stage of upper tract transitional cell carcinoma. References 1 : Tumors of the upper urinary tract: 10 years of experience.. J. Urol.1991; 146: 1243. Abstract, Google Scholar 2 : Primary tumors of the renal pelvis: evaluation of clinical and pathological features in a consecutive series of 10 years.. J. Urol.1988; 140: 19. 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Abstract, Google Scholar Departments of Urology, Radiology and Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania.© 1997 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited ByLiao R, Gupta M, Schwen Z, Patel H, Kates M, Johnson M, Hahn N, McConkey D, Bivalacqua T and Pierorazio P (2018) Comparison of Pathological Stage in Patients Treated with and without Neoadjuvant Chemotherapy for High Risk Upper Tract Urothelial CarcinomaJournal of Urology, VOL. 200, NO. 1, (68-73), Online publication date: 1-Jul-2018.Laguna M (2018) Re: Neoadjuvant Chemotherapy Improves Survival of Patients with Upper Tract Urothelial CarcinomaJournal of Urology, VOL. 192, NO. 5, (1366-1366), Online publication date: 1-Nov-2014.Cutress M, Stewart G, Tudor E, Egong E, Wells-Cole S, Phipps S, Thomas B, Riddick A, McNeill S and Tolley D (2018) Endoscopic Versus Laparoscopic Management of Noninvasive Upper Tract Urothelial Carcinoma: 20-Year Single Center ExperienceJournal of Urology, VOL. 189, NO. 6, (2054-2061), Online publication date: 1-Jun-2013.Brien J, Shariat S, Herman M, Ng C, Scherr D, Scoll B, Uzzo R, Wille M, Eggener S, Terrell J, Lucas S, Lotan Y, Boorjian S and Raman J (2018) Preoperative Hydronephrosis, Ureteroscopic Biopsy Grade and Urinary Cytology Can Improve Prediction of Advanced Upper Tract Urothelial CarcinomaJournal of Urology, VOL. 184, NO. 1, (69-73), Online publication date: 1-Jul-2010.GOEL M, MAHENDRA V and ROBERTS J (2018) Percutaneous Management Of Renal Pelvic Urothelial Tumors: Long-Term FollowupJournal of Urology, VOL. 169, NO. 3, (925-930), Online publication date: 1-Mar-2003.CHOW G, PATTERSON D, BLUTE M and SEGURA J (2018) Ureteroscopy: Effect of Technology and Technique on Clinical PracticeJournal of Urology, VOL. 170, NO. 1, (99-102), Online publication date: 1-Jul-2003.Chen G, El-Gabry E and Bagley D (2018) SURVEILLANCE OF UPPER URINARY TRACT TRANSITIONAL CELL CARCINOMA: : THE ROLE OF URETEROSCOPY, RETROGRADE PYELOGRAPHY, CYTOLOGY AND URINALYSISJournal of Urology, VOL. 164, NO. 6, (1901-1904), Online publication date: 1-Dec-2000.CHEN G and BAGLEY D (2018) URETEROSCOPIC MANAGEMENT OF UPPER TRACT TRANSITIONAL CELL CARCINOMA IN PATIENTS WITH NORMAL CONTRALATERAL KIDNEYSJournal of Urology, VOL. 164, NO. 4, (1173-1176), Online publication date: 1-Oct-2000.GUARNIZO E, PAVLOVICH C, SEIBA M, CARLSON D, DARRACOTT VAUGHAN E and SOSA R (2018) URETEROSCOPIC BIOPSY OF UPPER TRACT UROTHELIAL CARCINOMA: IMPROVED DIAGNOSTIC ACCURACY AND HISTOPATHOLOGICAL CONSIDERATIONS USING A MULTI-BIOPSY APPROACHJournal of Urology, VOL. 163, NO. 1, (52-55), Online publication date: 1-Jan-2000.CLARK P, STREEM S and GEISINGER M (2018) 13-YEAR EXPERIENCE WITH PERCUTANEOUS MANAGEMENT OF UPPER TRACT TRANSITIONAL CELL CARCINOMAJournal of Urology, VOL. 161, NO. 3, (772-776), Online publication date: 1-Mar-1999.HENDIN B, STREEM S, LEVIN H, KLEIN E and NOVICK A (2018) IMPACT OF DIAGNOSTIC URETEROSCOPY ON LONG-TERM SURVIVAL IN PATIENTS WITH UPPER TRACT TRANSITIONAL CELL CARCINOMAJournal of Urology, VOL. 161, NO. 3, (783-785), Online publication date: 1-Mar-1999.GRASSO M, LI S, LIU J, BEAGHLER M, NEWMAN R and BAGLEY D (2018) EXAMINING THE OBSTRUCTED URETER WITH INTRALUMINAL SONOGRAPHYJournal of Urology, VOL. 162, NO. 4, (1286-1290), Online publication date: 1-Oct-1999.Keeley F, Bibbo M and Bagley D (2018) Ureteroscopic Treatment and Surveillance of Upper Urinary Tract Transitional Cell CarcinomaJournal of Urology, VOL. 157, NO. 5, (1560-1565), Online publication date: 1-May-1997.Fuchs G (2018) Editorial: A Coming of Age-Percutaneous Endopyelotomy and a Technique to Watch Out for, that is Ureteroscopic Surgery for Upper Tract Transitional Cell CarcinomaJournal of Urology, VOL. 157, NO. 5, (1620-1621), Online publication date: 1-May-1997.Keeley F and Bagley D (2018) ADJUVANT MITOMYCIN C FOLLOWING ENDOSCOPIC TREATMENT OF UPPER TRACT TRANSITIONAL CELL CARCINOMAJournal of Urology, VOL. 158, NO. 6, (2074-2077), Online publication date: 1-Dec-1997. Volume 157Issue 1January 1997Page: 33-37 Advertisement Copyright & Permissions© 1997 by American Urological Association, Inc.MetricsAuthor Information Francis X. Keeley More articles by this author Deborah A. Kulp More articles by this author Marluce Bibbo More articles by this author Peter A. McCue More articles by this author Demetrius H. Bagley More articles by this author Expand All Advertisement PDF DownloadLoading ..." @default.
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