FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2151513540> ?p ?o ?g. }

• W2151513540 endingPage "236" @default.
• W2151513540 startingPage "229" @default.
• W2151513540 abstract "The significance of DNA breaks reported in failing hearts is controversial, although they may suggest myocyte apoptosis and may thus be responsible for the progression of heart failure. This study attempted to check the validity of the in situ markers for DNA breaks for detecting myocyte death and to evaluate separately two factors, failure or hypertrophy, crucial for DNA breaks in pathological human hearts. In the autopsy study, myocytes showed positivity for in situ nick end-labelling (TUNEL) and of Taq and Pfu polymerase-based in situ ligation assays not only in dilated cardiomyopathy (DCM, n = 9) with failure, but also in hypertrophic cardiomyopathy (HCM, n = 8) and hypertensive heart disease (HHD, n = 4) without failure. There was a significant correlation between each in situ marker and heart weight. The incidence of TUNEL-positive myocytes always exceeded that seen in in situ ligation assays. In addition, there were significant correlations between the in situ markers and the expression of the proliferating cell nuclear antigen (PCNA) and of the spliceosome component of 35 kD (SC-35). Similarly, in the left ventricular biopsy study using 23 DCM, 21 HCM, 11 HHD, and 13 non-hypertrophic hearts, the incidence of the in situ markers showed significant correlations with the left ventricular mass index and myocyte size, but not with cardiac function and dilatation. Positivity of myocytes for in situ markers for DNA breaks, such as TUNEL and in situ ligation assays, may be an epiphenomenon accompanying cardiac hypertrophy, but not myocyte death in pathological human hearts." @default.
• W2151513540 created "2016-06-24" @default.
• W2151513540 creator A5000496331 @default.
• W2151513540 creator A5004415631 @default.
• W2151513540 creator A5022669876 @default.
• W2151513540 creator A5031028550 @default.
• W2151513540 creator A5040436699 @default.
• W2151513540 creator A5042027614 @default.
• W2151513540 creator A5055957187 @default.
• W2151513540 creator A5066511998 @default.
• W2151513540 creator A5077773904 @default.
• W2151513540 creator A5087541787 @default.
• W2151513540 date "2003-01-17" @default.
• W2151513540 modified "2023-10-16" @default.
• W2151513540 title "Myocytes positive forin situ markers for DNA breaks in human hearts which are hypertrophic, but neither failed nor dilated: a manifestation of cardiac hypertrophy rather than failure" @default.
• W2151513540 cites W1489130191 @default.
• W2151513540 cites W1832181040 @default.
• W2151513540 cites W1858389298 @default.
• W2151513540 cites W1965623749 @default.
• W2151513540 cites W1970729738 @default.
• W2151513540 cites W2007368906 @default.
• W2151513540 cites W2021096466 @default.
• W2151513540 cites W2024195033 @default.
• W2151513540 cites W2034096812 @default.
• W2151513540 cites W2045946370 @default.
• W2151513540 cites W2056982291 @default.
• W2151513540 cites W2067539483 @default.
• W2151513540 cites W2067822361 @default.
• W2151513540 cites W2068327935 @default.
• W2151513540 cites W2071874082 @default.
• W2151513540 cites W2075116129 @default.
• W2151513540 cites W2077757665 @default.
• W2151513540 cites W2088749722 @default.
• W2151513540 cites W2098328780 @default.
• W2151513540 cites W2111951034 @default.
• W2151513540 cites W2120278715 @default.
• W2151513540 cites W2126012511 @default.
• W2151513540 cites W2128694891 @default.
• W2151513540 cites W2142792362 @default.
• W2151513540 cites W2151307785 @default.
• W2151513540 cites W2157042020 @default.
• W2151513540 cites W2317845988 @default.
• W2151513540 cites W2341478304 @default.
• W2151513540 cites W77897075 @default.
• W2151513540 doi "https://doi.org/10.1002/path.1261" @default.
• W2151513540 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12533836" @default.
• W2151513540 hasPublicationYear "2003" @default.
• W2151513540 type Work @default.
• W2151513540 sameAs 2151513540 @default.
• W2151513540 citedByCount "38" @default.
• W2151513540 countsByYear W21515135402013 @default.
• W2151513540 countsByYear W21515135402015 @default.
• W2151513540 countsByYear W21515135402016 @default.
• W2151513540 countsByYear W21515135402017 @default.
• W2151513540 countsByYear W21515135402018 @default.
• W2151513540 crossrefType "journal-article" @default.
• W2151513540 hasAuthorship W2151513540A5000496331 @default.
• W2151513540 hasAuthorship W2151513540A5004415631 @default.
• W2151513540 hasAuthorship W2151513540A5022669876 @default.
• W2151513540 hasAuthorship W2151513540A5031028550 @default.
• W2151513540 hasAuthorship W2151513540A5040436699 @default.
• W2151513540 hasAuthorship W2151513540A5042027614 @default.
• W2151513540 hasAuthorship W2151513540A5055957187 @default.
• W2151513540 hasAuthorship W2151513540A5066511998 @default.
• W2151513540 hasAuthorship W2151513540A5077773904 @default.
• W2151513540 hasAuthorship W2151513540A5087541787 @default.
• W2151513540 hasConcept C126322002 @default.
• W2151513540 hasConcept C142724271 @default.
• W2151513540 hasConcept C164705383 @default.
• W2151513540 hasConcept C167414201 @default.
• W2151513540 hasConcept C196795494 @default.
• W2151513540 hasConcept C204232928 @default.
• W2151513540 hasConcept C207200792 @default.
• W2151513540 hasConcept C2776383484 @default.
• W2151513540 hasConcept C2778198053 @default.
• W2151513540 hasConcept C2780185194 @default.
• W2151513540 hasConcept C3018686881 @default.
• W2151513540 hasConcept C71924100 @default.
• W2151513540 hasConcept C86803240 @default.
• W2151513540 hasConceptScore W2151513540C126322002 @default.
• W2151513540 hasConceptScore W2151513540C142724271 @default.
• W2151513540 hasConceptScore W2151513540C164705383 @default.
• W2151513540 hasConceptScore W2151513540C167414201 @default.
• W2151513540 hasConceptScore W2151513540C196795494 @default.
• W2151513540 hasConceptScore W2151513540C204232928 @default.
• W2151513540 hasConceptScore W2151513540C207200792 @default.
• W2151513540 hasConceptScore W2151513540C2776383484 @default.
• W2151513540 hasConceptScore W2151513540C2778198053 @default.
• W2151513540 hasConceptScore W2151513540C2780185194 @default.
• W2151513540 hasConceptScore W2151513540C3018686881 @default.
• W2151513540 hasConceptScore W2151513540C71924100 @default.
• W2151513540 hasConceptScore W2151513540C86803240 @default.
• W2151513540 hasIssue "2" @default.
• W2151513540 hasLocation W21515135401 @default.
• W2151513540 hasLocation W21515135402 @default.
• W2151513540 hasOpenAccess W2151513540 @default.
• W2151513540 hasPrimaryLocation W21515135401 @default.
• W2151513540 hasRelatedWork W2006176619 @default.

• next