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• W2151521621 startingPage "823" @default.
• W2151521621 abstract "Neurofilaments (NFs) are a major constituent of nerve cell axons that assemble from three subunit proteins of low (NF-L), medium (NF-M), and high (NF-H) molecular weight into a 10 nm diameter rod with radiating sidearms to form a bottle-brush-like structure. Here, we reassemble NFs in vitro from varying weight ratios of the subunit proteins, purified from bovine spinal cord, to form homopolymers of NF-L or filaments composed of NF-L and NF-M (NF-LM), NF-L and NF-H (NF-LH), or all three subunits (NF-LMH). At high protein concentrations, NFs align to form a nematic liquid crystalline gel with a well-defined spacing determined with synchrotron small angle x-ray scattering. Near physiological conditions (86 mM monovalent salt and pH 6.8), NF-LM networks with a high NF-M grafting density favor nematic ordering whereas filaments composed of NF-LH transition to an isotropic gel at low protein concentrations as a function of increasing mole fraction of NF-H subunits. The interfilament distance decreases with NF-M grafting density, opposite the trend seen with NF-LH networks. This suggests a competition between the more attractive NF-M sidearms, forming a compact aligned nematic gel, and the repulsive NF-H sidearms, favoring a more expansive isotropic gel, at 86 mM monovalent salt. These interactions are highly salt dependent and the nematic gel phase is stabilized with increasing monovalent salt." @default.
• W2151521621 created "2016-06-24" @default.
• W2151521621 creator A5003298888 @default.
• W2151521621 creator A5008710205 @default.
• W2151521621 date "2008-07-01" @default.
• W2151521621 modified "2023-10-02" @default.
• W2151521621 title "Interplay between Liquid Crystalline and Isotropic Gels in Self-Assembled Neurofilament Networks" @default.
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• W2151521621 doi "https://doi.org/10.1529/biophysj.107.127415" @default.
• W2151521621 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2440473" @default.
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• W2151521621 hasPublicationYear "2008" @default.
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