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- W2151536432 abstract "Eine Hemmung der Cyclooxygenase-Reaktion bei der Prostaglandinbildung des Rattennierenmarks in vitro ist durch verschiedene Flavonoide mit o-Dihydroxystrukturen möglich. Diese Flavonoide mit einer Brenzcatechin-Anordnung im Molekül besitzen ausgeprägte Radikalfängereigenschaften für Peroxid-Anion-Radikale. Dagegen können einige Flavonoide und Phenolderivate, die starke O2−•-Radikalfänger sind, die Prostaglandinsynthetase aber auch aktivieren oder unbeeinflußt lassen. Eine Korrelation zwischen den Radikalfängereigenschaften und der Beeinflussung des Cyclooxygenase-Enzyms besteht folglich bei den untersuchten Verbindungen nicht. Prostaglandin Synthetase Inhibition by Flavonoids and Phenolic Compounds in Relation to their O2−•-Scavenging Properties Several flavonoids containing an o-dihydroxy function inhibit the cyclo-oxygenase reaction during prostaglandin formation in the renal medulla of the rat. These flavonoids are strong scavengers for peroxide anion radicals. On the other hand, some flavonoids and phenolic compounds with strong O2−•-scavenging properties either stimulate the prostaglandin synthetase or have no effects. Thus, the radical scavenging properties of the compounds studied do not correlate with their influences on the cyclo-oxygenase activity." @default.
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- W2151536432 date "1980-01-01" @default.
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- W2151536432 title "Hemmung der Prostaglandinsynthetase durch Flavonoide und Phenolderivate im Vergleich mit deren O2−•-Radikalfänger-eigenschaften" @default.
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- W2151536432 doi "https://doi.org/10.1002/ardp.19803130409" @default.
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