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- W2151552476 abstract "Abstract Mutations in the gene ced-3, which encodes a protease similar to interleukin-1β converting enzyme and related proteins termed caspases, prevent programmed cell death in the nematode Caenorhabditis elegans. We used site-directed mutagenesis to demonstrate that both the presumptive active-site cysteine of the CED-3 protease and the aspartate residues at sites of processing of the CED-3 proprotein are required for programmed cell death in vivo. We characterized the phenotypes caused by and the molecular lesions of 52 ced-3 alleles. These alleles can be ordered in a graded phenotypic series. Of the 30 amino acid sites altered by ced-3 missense mutations, 29 are conserved with at least one other caspase, suggesting that these residues define sites important for the functions of all caspases. Animals homozygous for the ced-3(n2452) allele, which is deleted for the region of the ced-3 gene that encodes the protease domain, seemed to be incompletely blocked in programmed cell death, suggesting that some programmed cell death can occur independently of CED-3 protease activity." @default.
- W2151552476 created "2016-06-24" @default.
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- W2151552476 date "1999-12-01" @default.
- W2151552476 modified "2023-10-10" @default.
- W2151552476 title "Mutational Analysis of the Caenorhabditis elegans Cell-Death Gene ced-3" @default.
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- W2151552476 doi "https://doi.org/10.1093/genetics/153.4.1655" @default.
- W2151552476 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1460877" @default.
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