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• W2151571379 abstract "<b>Background:</b> Inhaled corticosteroids (ICS) provide short term benefits in asthma but the long term effects are still unknown. <b>Methods:</b> 281 patients diagnosed with moderate to severe asthma in 1963–75 were re-examined in 1991–9. Information was collected on forced expiratory volume in 1 second (FEV₁), bronchial hyperresponsiveness, atopy, smoking, use and dosage of oral and ICS. Patients were included in the analyses if they had at least three FEV₁ measurements during two consecutive years after the age of 30 and used ICS during follow up. <b>Results:</b> Analyses were performed on 122 patients. During a median follow up period of 23 years, 71 men and 51 women had on average 37 and 40 individual FEV₁ measurements, respectively. Linear mixed effect models showed that men had a mean annual decline in FEV₁ of 20.6 ml/year less after ICS initiation than before (p = 0.011), and in women the decline in FEV₁ was 3.2 ml/year less (p = 0.73). In individuals with <5 pack years of smoking the decline in FEV₁ was 36.8 ml/year less after ICS institution in men (p = 0.0097) and 0.8 ml/year less in women (p = 0.94), the difference between the sexes being significant (p = 0.045). These effects were not observed in those with ⩾5 pack years smoking. A higher daily dose of ICS was associated with a smaller decline in FEV₁ in men (p = 0.006), an effect not observed in women. <b>Conclusion:</b> Treatment with ICS in adult patients with moderate to severe asthma was associated with a reduction in the decline in FEV₁ over a 23 year follow up period in men who had smoked <5 pack years. This effect was dose dependent and was not present in women or in men with ⩾5 pack years of smoking at follow up. The lack of effect of ICS on the decline in FEV₁ in women needs further study." @default.
• W2151571379 created "2016-06-24" @default.
• W2151571379 creator A5072320602 @default.
• W2151571379 date "2006-02-01" @default.
• W2151571379 modified "2023-10-10" @default.
• W2151571379 title "Lung function decline in asthma: association with inhaled corticosteroids, smoking and sex" @default.
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• W2151571379 doi "https://doi.org/10.1136/thx.2004.039271" @default.
• W2151571379 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2104585" @default.
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