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• W2151584797 abstract "There is an increasing interest in cellular therapy for cardiovascular diseases. The first well-designed clinical trials have shown tantalizing hints that bone marrow cells may improve cardiac function post-myocardial infarction (post-MI)1,2 and enhance perfusion in patients with critical limb ischaemia.3 This cautious optimism comes on the heels of the great disappointment with pro-angiogenic gene therapy, which failed to live up to the promise based on encouraging pre-clinical studies and early, largely anecdotal clinical experience.4 However, even accepting that cell therapy may have a significant beneficial effect, the magnitude of this benefit would seem to be rather modest.5 Although there are many reasons for this, related both to the host (age, cardiovascular risk factors, and co-morbidities) as well as the cells themselves (type, ‘dose’, delivery route, and activity), it seems clear that strategies to enhance the regenerative capacity of stem or progenitor cells will be needed to effect robust clinical improvements.Bone marrow-derived mesenchymal stromal cells (MSCs) offer exciting potential in therapy of cardiovascular diseases and have been studied extensively. They have been reported to induce angiogenesis in models of myocardial6,7 and hindlimb ischaemia.8 They have also been shown to inhibit cardiomyocyte apoptosis, reduce remodelling, and improve myocardial function in the post-infarct myocardium.9 Their functional benefit in the heart was originally attributed to their ability to differentiate into cardiomyocytes,10 although evidence of engraftment and differentiation is often lacking. Greater attention has recently been placed on their ability to secrete paracrine growth factors,11 which act to reduce cardiomyocyte apoptosis and immune cell proliferation,12 together reducing inflammation and fibrosis. MSCs have been shown to secrete several mitogenic and angiogenic growth factors, including VEGF, IGF-1, EGF, angiopoietin-1, and SDF-1.12 In … *Corresponding author. Tel: +1 613 761 5341; fax: +1 613 761 4920. E-mail address: djstewart{at}ohri.ca" @default.
• W2151584797 created "2016-06-24" @default.
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• W2151584797 date "2008-05-02" @default.
• W2151584797 modified "2023-09-23" @default.
• W2151584797 title "Erythropoietin and mesenchymal stromal cells in angiogenesis and myocardial regeneration: one plus one equals three?" @default.
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• W2151584797 doi "https://doi.org/10.1093/cvr/cvn153" @default.
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