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• W2151634729 endingPage "4785" @default.
• W2151634729 startingPage "4775" @default.
• W2151634729 abstract "Although twin studies indicate clear genetic bases of autism spectrum disorder (ASD), the precise mechanisms through which genetic variations causally result in ASD are poorly understood. Individuals with 3 Mb and nested 1.5 Mb hemizygosity of the chromosome 22q11.2 represent genetically identifiable cases of ASD. However, because more than 30 genes are deleted even in the minimal deletion cases of 22q11.2 deficiency, the individual 22q11.2 gene(s) responsible for ASD remain elusive. Here, we examined the impact of constitutive heterozygosity of Tbx1, a 22q11.2 gene, on the behavioral phenotypes of ASD and characterized the regional and cellular expression of its mRNA and protein in mice. Congenic Tbx1 heterozygous (HT) mice were impaired in social interaction, ultrasonic vocalization, memory-based behavioral alternation, working memory and thigmotaxis, compared with wild-type (WT) mice. These phenotypes were not due to non-specific alterations in olfactory function, exploratory behavior, motor movement or anxiety-related behavior. Tbx1 mRNA and protein were ubiquitously expressed throughout the brains of C57BL/6J mice, but protein expression was enriched in regions that postnatally retain the capacity of neurogenesis, and in fact, postnatally proliferating cells expressed Tbx1. In postnatally derived hippocampal culture cells of C57BL/6J mice, Tbx1 levels were higher during proliferation than during differentiation, and expressed in neural progenitor cells, immature and matured neurons and glial cells. Taken together, our data suggest that Tbx1 is a gene responsible for the phenotypes of 22q11.2 hemizygosity-associated ASD possibly through its role in diverse cell types, including postnatally and prenatally generated neurons." @default.
• W2151634729 created "2016-06-24" @default.
• W2151634729 creator A5008136067 @default.
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• W2151634729 creator A5060746663 @default.
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• W2151634729 creator A5078310718 @default.
• W2151634729 date "2011-09-09" @default.
• W2151634729 modified "2023-10-18" @default.
• W2151634729 title "Tbx1: identification of a 22q11.2 gene as a risk factor for autism spectrum disorder in a mouse model" @default.
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• W2151634729 doi "https://doi.org/10.1093/hmg/ddr404" @default.
• W2151634729 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3221538" @default.
• W2151634729 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21908517" @default.
• W2151634729 hasPublicationYear "2011" @default.
• W2151634729 type Work @default.
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