FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2151646064> ?p ?o ?g. }

• W2151646064 abstract "In mammals, interleukin 2 (IL-2) has been shown to decrease replication or attenuate pathogenicity of numerous viral pathogens (herpes simplex virus, vaccinia virus, human respiratory syncytial virus, human immunodeficiency virus) by activating natural killer cells (NK), cytotoxic T lymphocytes and expanding subsets of memory cells. In chickens, IL-2 has been shown to activate T cells, and as such it might have the potential to affect replication and pathogenesis of Newcastle disease virus (NDV).To assess the effect of IL-2 during NDV infection in chickens, we produced a recombinant virulent NDV strain expressing chicken IL-2 (rZJ1-IL2). The effects of IL-2 expression were investigated in vivo using the intracerebral pathogenicity index (ICPI) in day-old chicks and pathogenesis experiments in 4-week-old chickens. In these studies, rZJ1-IL2 was compared to a control virus expressing the green fluorescent protein (rZJ1-GFP). Assessed parameters included survival curves, detailed histological and immunohistochemical grading of lesions in multiple organs, and virus isolation in blood, spleen and mucosal secretions of infected birds.At the site of infection (eyelid), expression of IL-2 was demonstrated in areas of rZJ-IL2 replication, confirming IL-2 production in vivo. Compared to rZJ1-GFP strain, rZJ1-IL2 caused milder lesions and displayed decreased viral load in blood, spleen and mucosal secretions of infected birds. In the rZJ1-IL2-infected group, virus level in the blood peaked at day 4 post-infection (pi) (10(3.46) EID50 /0.1 ml) and drastically decreased at day 5 pi (10(0.9) EID50/0.1 ml), while in the rZJ1-GFP-infected group virus levels in the blood reached 10(5.35) EID50/0.1 ml at day 5. However, rZJ1-IL2-infected groups presented survival curves similar to control birds infected with rZJ1-GFP, with comparable clinical signs and 100 % mortality. Further, expression of IL-2 did not significantly affect the ICPI scores, compared to rZJ1-GFP strain.Increased expression of chicken IL-2 during virulent NDV replication in naïve chickens decreased viral titers in blood, spleens, oral and cloacal secretions on day 4-5 post infection. This is consistent with the previously described role of IL-2 in enhancing the clearance of viruses in mammals, such as human respiratory syncytial virus." @default.
• W2151646064 created "2016-06-24" @default.
• W2151646064 creator A5001595321 @default.
• W2151646064 creator A5001722770 @default.
• W2151646064 creator A5039449382 @default.
• W2151646064 creator A5045204229 @default.
• W2151646064 creator A5069603609 @default.
• W2151646064 creator A5085129811 @default.
• W2151646064 creator A5088183327 @default.
• W2151646064 creator A5089532282 @default.
• W2151646064 date "2015-08-08" @default.
• W2151646064 modified "2023-10-16" @default.
• W2151646064 title "Expression of chicken interleukin-2 by a highly virulent strain of Newcastle disease virus leads to decreased systemic viral load but does not significantly affect mortality in chickens" @default.
• W2151646064 cites W1489222618 @default.
• W2151646064 cites W1606933409 @default.
• W2151646064 cites W1965893133 @default.
• W2151646064 cites W1968902673 @default.
• W2151646064 cites W1974688938 @default.
• W2151646064 cites W1984781939 @default.
• W2151646064 cites W1997185845 @default.
• W2151646064 cites W2001991267 @default.
• W2151646064 cites W2005132226 @default.
• W2151646064 cites W2005182075 @default.
• W2151646064 cites W2009644403 @default.
• W2151646064 cites W2027585770 @default.
• W2151646064 cites W2028992433 @default.
• W2151646064 cites W2033321639 @default.
• W2151646064 cites W2033805305 @default.
• W2151646064 cites W2037545477 @default.
• W2151646064 cites W2039023491 @default.
• W2151646064 cites W2039969585 @default.
• W2151646064 cites W2041376754 @default.
• W2151646064 cites W2052357030 @default.
• W2151646064 cites W2057673912 @default.
• W2151646064 cites W2058818590 @default.
• W2151646064 cites W2064869960 @default.
• W2151646064 cites W2070951718 @default.
• W2151646064 cites W2075170526 @default.
• W2151646064 cites W2077398566 @default.
• W2151646064 cites W2091053746 @default.
• W2151646064 cites W2092878885 @default.
• W2151646064 cites W2101305981 @default.
• W2151646064 cites W2129239355 @default.
• W2151646064 cites W2137387906 @default.
• W2151646064 cites W2137503785 @default.
• W2151646064 cites W2142923098 @default.
• W2151646064 cites W2146478689 @default.
• W2151646064 cites W2162193190 @default.
• W2151646064 cites W2165178527 @default.
• W2151646064 cites W2169868041 @default.
• W2151646064 cites W2170931516 @default.
• W2151646064 doi "https://doi.org/10.1186/s12985-015-0353-x" @default.
• W2151646064 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4528788" @default.
• W2151646064 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26253150" @default.
• W2151646064 hasPublicationYear "2015" @default.
• W2151646064 type Work @default.
• W2151646064 sameAs 2151646064 @default.
• W2151646064 citedByCount "24" @default.
• W2151646064 countsByYear W21516460642016 @default.
• W2151646064 countsByYear W21516460642017 @default.
• W2151646064 countsByYear W21516460642018 @default.
• W2151646064 countsByYear W21516460642020 @default.
• W2151646064 countsByYear W21516460642021 @default.
• W2151646064 countsByYear W21516460642022 @default.
• W2151646064 countsByYear W21516460642023 @default.
• W2151646064 crossrefType "journal-article" @default.
• W2151646064 hasAuthorship W2151646064A5001595321 @default.
• W2151646064 hasAuthorship W2151646064A5001722770 @default.
• W2151646064 hasAuthorship W2151646064A5039449382 @default.
• W2151646064 hasAuthorship W2151646064A5045204229 @default.
• W2151646064 hasAuthorship W2151646064A5069603609 @default.
• W2151646064 hasAuthorship W2151646064A5085129811 @default.
• W2151646064 hasAuthorship W2151646064A5088183327 @default.
• W2151646064 hasAuthorship W2151646064A5089532282 @default.
• W2151646064 hasBestOaLocation W21516460641 @default.
• W2151646064 hasConcept C104317684 @default.
• W2151646064 hasConcept C12914427 @default.
• W2151646064 hasConcept C140704245 @default.
• W2151646064 hasConcept C159047783 @default.
• W2151646064 hasConcept C203014093 @default.
• W2151646064 hasConcept C2522874641 @default.
• W2151646064 hasConcept C2777852405 @default.
• W2151646064 hasConcept C2778116459 @default.
• W2151646064 hasConcept C2780931953 @default.
• W2151646064 hasConcept C2780942790 @default.
• W2151646064 hasConcept C2781196997 @default.
• W2151646064 hasConcept C55493867 @default.
• W2151646064 hasConcept C60987743 @default.
• W2151646064 hasConcept C86803240 @default.
• W2151646064 hasConceptScore W2151646064C104317684 @default.
• W2151646064 hasConceptScore W2151646064C12914427 @default.
• W2151646064 hasConceptScore W2151646064C140704245 @default.
• W2151646064 hasConceptScore W2151646064C159047783 @default.
• W2151646064 hasConceptScore W2151646064C203014093 @default.
• W2151646064 hasConceptScore W2151646064C2522874641 @default.
• W2151646064 hasConceptScore W2151646064C2777852405 @default.
• W2151646064 hasConceptScore W2151646064C2778116459 @default.
• W2151646064 hasConceptScore W2151646064C2780931953 @default.
• W2151646064 hasConceptScore W2151646064C2780942790 @default.
• W2151646064 hasConceptScore W2151646064C2781196997 @default.

• next