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- W2151657605 endingPage "12520" @default.
- W2151657605 startingPage "12506" @default.
- W2151657605 abstract "A straightforward method has been developed for the synthesis of the benzimidazole ring system through a carbon-nitrogen cross-coupling reaction. In the presence of 2.0 equiv. of K2CO3 in water at 100 °C for 30 h, the intramolecular cyclization of N-(2-iodoaryl)benzamidine provides benzimidazole derivatives in moderate to high yields. Remarkably, the procedure occurs exclusively in water and doesn’t require the use of any additional reagent/catalyst, rendering the methodology highly valuable from both environmental and economical points of view." @default.
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- W2151657605 date "2012-10-24" @default.
- W2151657605 modified "2023-10-18" @default.
- W2151657605 title "Aqueous Synthesis of 1-H-2-Substituted Benzimidazoles via Transition-Metal-Free Intramolecular Amination of Aryl Iodides" @default.
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- W2151657605 doi "https://doi.org/10.3390/molecules171112506" @default.
- W2151657605 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6268300" @default.
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