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- W2151665918 abstract "In recent decades, the increase in human longevity has made it increasingly important to expand our knowledge on aging. To accomplish this, the use of animal models is essential, with the most common being mouse (phylogenetically similar to humans, and a model with a long life expectancy) and Caenorhabditis elegans (an invertebrate with a short life span, but quite removed from us in evolutionary terms). However, some sort of model is needed to bridge the differences between those mentioned above, achieving a balance between phylogenetic distance and life span. Fish of the genus Nothobranchius were suggested 10 years ago as a possible alternative for the study of the aging process. In the meantime, numerous studies have been conducted at different levels: behavioral (including the study of the rest-activity rhythm), populational, histochemical, biochemical and genetic, among others, with very positive results. This review compiles what we know about Nothobranchius to date, and examines its future prospects as a true alternative to the classic models for studies on aging." @default.
- W2151665918 created "2016-06-24" @default.
- W2151665918 creator A5043083913 @default.
- W2151665918 creator A5044726337 @default.
- W2151665918 creator A5053067688 @default.
- W2151665918 creator A5086793219 @default.
- W2151665918 date "2014-01-01" @default.
- W2151665918 modified "2023-09-22" @default.
- W2151665918 title "Nothobranchius as a model for aging studies. A review" @default.
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- W2151665918 doi "https://doi.org/10.14336/ad.2014.0500281" @default.