FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2151677958> ?p ?o ?g. }

• W2151677958 endingPage "2012" @default.
• W2151677958 startingPage "2000" @default.
• W2151677958 abstract "Rb/E2F is dysregulated in murine and human pituitary tumors. Pituitary tumor transforming gene (PTTG1), a securin protein, is required for pituitary tumorigenesis, and PTTG1 deletion attenuates pituitary tumor development in Rb(+/-) mice. E2F1 and PTTG1 were concordantly overexpressed in 29 of 46 Rb(+/-) murine pituitary tissues and also in 45 of 80 human pituitary tumors (P < 0.05). E2F1 specifically bound the hPTTG1 promoter as assessed by chromatin immunoprecipitation and biotin-streptavidin pull-down assay, indicating that hPTTG1 may act as a direct E2F1 target. Transfection of E2F1 and its partner DP1 dose-dependently activated hPTTG1 transcription up to 3-fold in p53-devoid H1299 cells but not in p53-replete HCT116 cells. E2F1 overexpression enhanced endogenous hPTTG1 mRNA and protein levels up to 3-fold in H1299 cells. The presence of endogenous p53/p21 constrained the induction, whereas knocking down either p53 or p21 in HCT116 cells restored E2F1-induced hPTTG1 transactivation and expression. Moreover, suppressing Rb by small interfering RNA concordantly elevated E2F1 and hPTTG1 protein levels. In contrast, transfection of E2F1 small interfering RNA lowered hPTTG1 levels 24 h later in HCT116 than in H1299 cells, indicating that p53 delays E2F1 action on hPTTG1. These results elucidate a mechanism for abundant tumor hPTTG1 expression, whereby Rb inactivation releases E2F1 to induce hPTTG1. This signaling pathway may underlie the requirement of PTTG1 for pituitary tumorigenesis." @default.
• W2151677958 created "2016-06-24" @default.
• W2151677958 creator A5002866531 @default.
• W2151677958 creator A5012286335 @default.
• W2151677958 creator A5060864838 @default.
• W2151677958 creator A5066985276 @default.
• W2151677958 creator A5073387528 @default.
• W2151677958 date "2009-12-01" @default.
• W2151677958 modified "2023-09-24" @default.
• W2151677958 title "E2F1 Induces Pituitary Tumor Transforming Gene (PTTG1) Expression in Human Pituitary Tumors" @default.
• W2151677958 cites W1969995414 @default.
• W2151677958 cites W1972398909 @default.
• W2151677958 cites W1972857453 @default.
• W2151677958 cites W1975957264 @default.
• W2151677958 cites W1983335481 @default.
• W2151677958 cites W1984328656 @default.
• W2151677958 cites W1999330214 @default.
• W2151677958 cites W2001070862 @default.
• W2151677958 cites W2006390282 @default.
• W2151677958 cites W2009910507 @default.
• W2151677958 cites W2010794110 @default.
• W2151677958 cites W2014149453 @default.
• W2151677958 cites W2018072030 @default.
• W2151677958 cites W2020899639 @default.
• W2151677958 cites W2026358387 @default.
• W2151677958 cites W2028437210 @default.
• W2151677958 cites W2034373123 @default.
• W2151677958 cites W2038197766 @default.
• W2151677958 cites W2040035255 @default.
• W2151677958 cites W2041519240 @default.
• W2151677958 cites W2049427614 @default.
• W2151677958 cites W2051862020 @default.
• W2151677958 cites W2056187099 @default.
• W2151677958 cites W2061665609 @default.
• W2151677958 cites W2062786258 @default.
• W2151677958 cites W2063367127 @default.
• W2151677958 cites W2069678419 @default.
• W2151677958 cites W2071450690 @default.
• W2151677958 cites W2075025477 @default.
• W2151677958 cites W2080149096 @default.
• W2151677958 cites W2083187335 @default.
• W2151677958 cites W2087556564 @default.
• W2151677958 cites W2089218510 @default.
• W2151677958 cites W2092868756 @default.
• W2151677958 cites W2104519300 @default.
• W2151677958 cites W2111329154 @default.
• W2151677958 cites W2120948678 @default.
• W2151677958 cites W2142282076 @default.
• W2151677958 cites W2146513771 @default.
• W2151677958 cites W2148043102 @default.
• W2151677958 cites W2148474812 @default.
• W2151677958 cites W2152459272 @default.
• W2151677958 cites W2154082643 @default.
• W2151677958 cites W2159403437 @default.
• W2151677958 cites W2166086329 @default.
• W2151677958 cites W2166644095 @default.
• W2151677958 cites W2168459422 @default.
• W2151677958 cites W2171280085 @default.
• W2151677958 cites W3029303231 @default.
• W2151677958 doi "https://doi.org/10.1210/me.2009-0161" @default.
• W2151677958 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2796149" @default.
• W2151677958 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19837943" @default.
• W2151677958 hasPublicationYear "2009" @default.
• W2151677958 type Work @default.
• W2151677958 sameAs 2151677958 @default.
• W2151677958 citedByCount "33" @default.
• W2151677958 countsByYear W21516779582012 @default.
• W2151677958 countsByYear W21516779582013 @default.
• W2151677958 countsByYear W21516779582014 @default.
• W2151677958 countsByYear W21516779582015 @default.
• W2151677958 countsByYear W21516779582016 @default.
• W2151677958 countsByYear W21516779582017 @default.
• W2151677958 countsByYear W21516779582018 @default.
• W2151677958 countsByYear W21516779582019 @default.
• W2151677958 countsByYear W21516779582020 @default.
• W2151677958 countsByYear W21516779582022 @default.
• W2151677958 crossrefType "journal-article" @default.
• W2151677958 hasAuthorship W2151677958A5002866531 @default.
• W2151677958 hasAuthorship W2151677958A5012286335 @default.
• W2151677958 hasAuthorship W2151677958A5060864838 @default.
• W2151677958 hasAuthorship W2151677958A5066985276 @default.
• W2151677958 hasAuthorship W2151677958A5073387528 @default.
• W2151677958 hasBestOaLocation W21516779582 @default.
• W2151677958 hasConcept C101762097 @default.
• W2151677958 hasConcept C104317684 @default.
• W2151677958 hasConcept C134018914 @default.
• W2151677958 hasConcept C134320426 @default.
• W2151677958 hasConcept C150194340 @default.
• W2151677958 hasConcept C153911025 @default.
• W2151677958 hasConcept C173396325 @default.
• W2151677958 hasConcept C183022183 @default.
• W2151677958 hasConcept C190232843 @default.
• W2151677958 hasConcept C22615655 @default.
• W2151677958 hasConcept C2776062698 @default.
• W2151677958 hasConcept C2781449511 @default.
• W2151677958 hasConcept C29537977 @default.
• W2151677958 hasConcept C502942594 @default.
• W2151677958 hasConcept C54009773 @default.

• next