FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2151678034> ?p ?o ?g. }

• W2151678034 abstract "Boswellia has been widely used in traditional medicine for the treatment of different diseases such as cancer in Iran. The aim of this study was to evaluate the effect of the gum methanol extract of Boswellia thurifera on the viability and P53 gene expression of cultured breast cancer cells. The gum methanol extract was obtained in various concentrations using the maceration method. Normal (HEK-293) and cancer (MDA-MB-231) human cells were cultured and treated with various concentrations of the extract. Then MTT assay was used for the study of cytotoxic effect of the extract and real time PCR method was also applied for the investigation of P53 gene expression in cancer cells. The IC50 of the extract against cancer cells was 80 µg/mL and had less cytotoxic effect in normal cells. The effect of the extract was dose dependent. Induction of P53 expression by extract was also significantly more in treated cancer cells than untreated cells. This inductive effect in cells was higher after 12 h treatment than it was after 6 h. The results of the current study show that gum methanol extract of Boswellia thurifera has probably anti-cancer effects and could induce P53 gene transcription and toxicity in the cultured breast cancer cell line. The increase of P53 gene specific mRNA may be a mechanism of gum methanol extract induced cytotoxicity. However, for a definitive conclusion, further studies on other cell lines as well as animal models and subsequent clinical studies are warranted." @default.
• W2151678034 created "2016-06-24" @default.
• W2151678034 creator A5026719431 @default.
• W2151678034 creator A5028892329 @default.
• W2151678034 creator A5076030334 @default.
• W2151678034 date "2014-01-01" @default.
• W2151678034 modified "2023-09-23" @default.
• W2151678034 title "Effect of boswellia thurifera gum methanol extract on cytotoxicity and p53 gene expression in human breast cancer cell line." @default.
• W2151678034 cites W152041627 @default.
• W2151678034 cites W1521544005 @default.
• W2151678034 cites W1546398239 @default.
• W2151678034 cites W1663251599 @default.
• W2151678034 cites W1982035852 @default.
• W2151678034 cites W1985363587 @default.
• W2151678034 cites W2002122394 @default.
• W2151678034 cites W2007195740 @default.
• W2151678034 cites W2014094015 @default.
• W2151678034 cites W2016294835 @default.
• W2151678034 cites W2034372828 @default.
• W2151678034 cites W2041340074 @default.
• W2151678034 cites W2065174183 @default.
• W2151678034 cites W2082196272 @default.
• W2151678034 cites W2088130246 @default.
• W2151678034 cites W2114918609 @default.
• W2151678034 cites W2115736296 @default.
• W2151678034 cites W2123133309 @default.
• W2151678034 cites W2157114690 @default.
• W2151678034 cites W2162331245 @default.
• W2151678034 cites W2256004254 @default.
• W2151678034 cites W2341050657 @default.
• W2151678034 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4157048" @default.
• W2151678034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25237368" @default.
• W2151678034 hasPublicationYear "2014" @default.
• W2151678034 type Work @default.
• W2151678034 sameAs 2151678034 @default.
• W2151678034 citedByCount "8" @default.
• W2151678034 countsByYear W21516780342014 @default.
• W2151678034 countsByYear W21516780342015 @default.
• W2151678034 countsByYear W21516780342017 @default.
• W2151678034 countsByYear W21516780342019 @default.
• W2151678034 countsByYear W21516780342022 @default.
• W2151678034 crossrefType "journal-article" @default.
• W2151678034 hasAuthorship W2151678034A5026719431 @default.
• W2151678034 hasAuthorship W2151678034A5028892329 @default.
• W2151678034 hasAuthorship W2151678034A5076030334 @default.
• W2151678034 hasConcept C109316439 @default.
• W2151678034 hasConcept C121608353 @default.
• W2151678034 hasConcept C126322002 @default.
• W2151678034 hasConcept C1491633281 @default.
• W2151678034 hasConcept C154317977 @default.
• W2151678034 hasConcept C185592680 @default.
• W2151678034 hasConcept C202751555 @default.
• W2151678034 hasConcept C2780783641 @default.
• W2151678034 hasConcept C29730261 @default.
• W2151678034 hasConcept C530470458 @default.
• W2151678034 hasConcept C53227056 @default.
• W2151678034 hasConcept C54355233 @default.
• W2151678034 hasConcept C55493867 @default.
• W2151678034 hasConcept C556039675 @default.
• W2151678034 hasConcept C71924100 @default.
• W2151678034 hasConcept C81885089 @default.
• W2151678034 hasConcept C86803240 @default.
• W2151678034 hasConcept C96232424 @default.
• W2151678034 hasConcept C98274493 @default.
• W2151678034 hasConceptScore W2151678034C109316439 @default.
• W2151678034 hasConceptScore W2151678034C121608353 @default.
• W2151678034 hasConceptScore W2151678034C126322002 @default.
• W2151678034 hasConceptScore W2151678034C1491633281 @default.
• W2151678034 hasConceptScore W2151678034C154317977 @default.
• W2151678034 hasConceptScore W2151678034C185592680 @default.
• W2151678034 hasConceptScore W2151678034C202751555 @default.
• W2151678034 hasConceptScore W2151678034C2780783641 @default.
• W2151678034 hasConceptScore W2151678034C29730261 @default.
• W2151678034 hasConceptScore W2151678034C530470458 @default.
• W2151678034 hasConceptScore W2151678034C53227056 @default.
• W2151678034 hasConceptScore W2151678034C54355233 @default.
• W2151678034 hasConceptScore W2151678034C55493867 @default.
• W2151678034 hasConceptScore W2151678034C556039675 @default.
• W2151678034 hasConceptScore W2151678034C71924100 @default.
• W2151678034 hasConceptScore W2151678034C81885089 @default.
• W2151678034 hasConceptScore W2151678034C86803240 @default.
• W2151678034 hasConceptScore W2151678034C96232424 @default.
• W2151678034 hasConceptScore W2151678034C98274493 @default.
• W2151678034 hasLocation W21516780341 @default.
• W2151678034 hasOpenAccess W2151678034 @default.
• W2151678034 hasPrimaryLocation W21516780341 @default.
• W2151678034 hasRelatedWork W1514985577 @default.
• W2151678034 hasRelatedWork W1595369531 @default.
• W2151678034 hasRelatedWork W1832971264 @default.
• W2151678034 hasRelatedWork W1983646144 @default.
• W2151678034 hasRelatedWork W2121647347 @default.
• W2151678034 hasRelatedWork W2130128364 @default.
• W2151678034 hasRelatedWork W2144163410 @default.
• W2151678034 hasRelatedWork W2166450419 @default.
• W2151678034 hasRelatedWork W2183567865 @default.
• W2151678034 hasRelatedWork W2187653422 @default.
• W2151678034 hasRelatedWork W2230969006 @default.
• W2151678034 hasRelatedWork W2346261729 @default.
• W2151678034 hasRelatedWork W2366814924 @default.
• W2151678034 hasRelatedWork W2583962011 @default.

• next