Matches in SemOpenAlex for { <https://semopenalex.org/work/W2151750304> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2151750304 endingPage "951" @default.
- W2151750304 startingPage "946" @default.
- W2151750304 abstract "Recently, we have found two major physiological forms of retinoid X receptor alpha (RXR alpha): the mature 54 kDa RXR alpha and the truncated 44 kDa RXR alpha lacking a portion of N-terminal A/B domain in human and rodent livers. In this communication, we show that m-calpain was active to digest 54 kDa RXR alpha in the human hepatoma-derived cell line, HuH7, nuclei to 44 kDa fragment through 47 kDa intermediate in vitro. Although both proteolytic fragments were revealed by anti-RXR alpha antibody against its E-domain, neither fragment reacted with anti-RXR alpha antibody specific for A/B domain. The profile of the calpain-induced proteolytic fragmentation of RXR alpha was almost identical to that endogenous RXR alpha in nonmalignant human and normal mouse liver nuclei. This is the first demonstration that of RXR alpha is a substrate for m-calpain, strongly suggesting that the enzyme might also be involved in post-translational modification of the receptor in hepatocytes." @default.
- W2151750304 created "2016-06-24" @default.
- W2151750304 creator A5010360445 @default.
- W2151750304 creator A5023727914 @default.
- W2151750304 creator A5041284607 @default.
- W2151750304 creator A5052708402 @default.
- W2151750304 creator A5057751525 @default.
- W2151750304 date "1996-08-01" @default.
- W2151750304 modified "2023-09-26" @default.
- W2151750304 title "Limited Degradation of Retinoid X Receptor by Calpain" @default.
- W2151750304 doi "https://doi.org/10.1006/bbrc.1996.1276" @default.
- W2151750304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8780715" @default.
- W2151750304 hasPublicationYear "1996" @default.
- W2151750304 type Work @default.
- W2151750304 sameAs 2151750304 @default.
- W2151750304 citedByCount "29" @default.
- W2151750304 countsByYear W21517503042012 @default.
- W2151750304 countsByYear W21517503042013 @default.
- W2151750304 countsByYear W21517503042014 @default.
- W2151750304 countsByYear W21517503042016 @default.
- W2151750304 countsByYear W21517503042017 @default.
- W2151750304 countsByYear W21517503042018 @default.
- W2151750304 countsByYear W21517503042019 @default.
- W2151750304 countsByYear W21517503042020 @default.
- W2151750304 countsByYear W21517503042021 @default.
- W2151750304 crossrefType "journal-article" @default.
- W2151750304 hasAuthorship W2151750304A5010360445 @default.
- W2151750304 hasAuthorship W2151750304A5023727914 @default.
- W2151750304 hasAuthorship W2151750304A5041284607 @default.
- W2151750304 hasAuthorship W2151750304A5052708402 @default.
- W2151750304 hasAuthorship W2151750304A5057751525 @default.
- W2151750304 hasConcept C104317684 @default.
- W2151750304 hasConcept C128821507 @default.
- W2151750304 hasConcept C153911025 @default.
- W2151750304 hasConcept C159110408 @default.
- W2151750304 hasConcept C170493617 @default.
- W2151750304 hasConcept C181199279 @default.
- W2151750304 hasConcept C2775944032 @default.
- W2151750304 hasConcept C2775954498 @default.
- W2151750304 hasConcept C2781121885 @default.
- W2151750304 hasConcept C49453240 @default.
- W2151750304 hasConcept C55493867 @default.
- W2151750304 hasConcept C56928146 @default.
- W2151750304 hasConcept C63932345 @default.
- W2151750304 hasConcept C64943373 @default.
- W2151750304 hasConcept C71924100 @default.
- W2151750304 hasConcept C86339819 @default.
- W2151750304 hasConcept C86803240 @default.
- W2151750304 hasConcept C95444343 @default.
- W2151750304 hasConceptScore W2151750304C104317684 @default.
- W2151750304 hasConceptScore W2151750304C128821507 @default.
- W2151750304 hasConceptScore W2151750304C153911025 @default.
- W2151750304 hasConceptScore W2151750304C159110408 @default.
- W2151750304 hasConceptScore W2151750304C170493617 @default.
- W2151750304 hasConceptScore W2151750304C181199279 @default.
- W2151750304 hasConceptScore W2151750304C2775944032 @default.
- W2151750304 hasConceptScore W2151750304C2775954498 @default.
- W2151750304 hasConceptScore W2151750304C2781121885 @default.
- W2151750304 hasConceptScore W2151750304C49453240 @default.
- W2151750304 hasConceptScore W2151750304C55493867 @default.
- W2151750304 hasConceptScore W2151750304C56928146 @default.
- W2151750304 hasConceptScore W2151750304C63932345 @default.
- W2151750304 hasConceptScore W2151750304C64943373 @default.
- W2151750304 hasConceptScore W2151750304C71924100 @default.
- W2151750304 hasConceptScore W2151750304C86339819 @default.
- W2151750304 hasConceptScore W2151750304C86803240 @default.
- W2151750304 hasConceptScore W2151750304C95444343 @default.
- W2151750304 hasIssue "3" @default.
- W2151750304 hasLocation W21517503041 @default.
- W2151750304 hasLocation W21517503042 @default.
- W2151750304 hasOpenAccess W2151750304 @default.
- W2151750304 hasPrimaryLocation W21517503041 @default.
- W2151750304 hasRelatedWork W1972115931 @default.
- W2151750304 hasRelatedWork W1973507868 @default.
- W2151750304 hasRelatedWork W1989928103 @default.
- W2151750304 hasRelatedWork W2037973801 @default.
- W2151750304 hasRelatedWork W2039428739 @default.
- W2151750304 hasRelatedWork W2047089003 @default.
- W2151750304 hasRelatedWork W2049911208 @default.
- W2151750304 hasRelatedWork W2352474452 @default.
- W2151750304 hasRelatedWork W2917119665 @default.
- W2151750304 hasRelatedWork W2987372952 @default.
- W2151750304 hasVolume "225" @default.
- W2151750304 isParatext "false" @default.
- W2151750304 isRetracted "false" @default.
- W2151750304 magId "2151750304" @default.
- W2151750304 workType "article" @default.