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- W2151752783 abstract "Collagen receptor integrins recycle between the plasma membrane and endosomes and facilitate formation and turnover of focal adhesions. In contrast, clustering of α2β1 integrin with antibodies or the human pathogen echovirus 1 (EV1) causes redistribution of α2 integrin to perinuclear multivesicular bodies, α2-MVBs. We show here that the internalized clustered α2 integrin remains in α2-MVBs and is not recycled back to the plasma membrane. Instead, receptor clustering and internalization lead to an accelerated down-regulation of α2β1 integrin compared to the slow turnover of unclustered α2 integrin. EV1 infection or integrin degradation is not associated with proteasomal or autophagosomal processes and shows no significant association with lysosomal pathway. In contrast, degradation is dependent on calpains, such that it is blocked by calpain inhibitors. We show that active calpain is present in α2-MVBs, internalized clustered α2β1 integrin coprecipitates with calpain-1, and calpain enzymes can degrade α2β1 integrin. In conclusion, we identified a novel virus- and clustering-specific pathway that diverts α2β1 integrin from its normal endo/exocytic traffic to a nonrecycling, calpain-dependent degradative endosomal route." @default.
- W2151752783 created "2016-06-24" @default.
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- W2151752783 date "2012-02-01" @default.
- W2151752783 modified "2023-10-16" @default.
- W2151752783 title "Calpains promote α2β1 integrin turnover in nonrecycling integrin pathway" @default.
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- W2151752783 cites W1590553747 @default.
- W2151752783 cites W1698873202 @default.
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- W2151752783 cites W1969025660 @default.
- W2151752783 cites W1969117282 @default.
- W2151752783 cites W1976380346 @default.
- W2151752783 cites W1996225493 @default.
- W2151752783 cites W1996349206 @default.
- W2151752783 cites W2009117970 @default.
- W2151752783 cites W2010618491 @default.
- W2151752783 cites W2022491847 @default.
- W2151752783 cites W2033218919 @default.
- W2151752783 cites W2038152024 @default.
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- W2151752783 cites W2074430151 @default.
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- W2151752783 cites W2082664513 @default.
- W2151752783 cites W2085700896 @default.
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- W2151752783 doi "https://doi.org/10.1091/mbc.e11-06-0548" @default.
- W2151752783 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3268724" @default.
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