Matches in SemOpenAlex for { <https://semopenalex.org/work/W2151799076> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2151799076 endingPage "287" @default.
- W2151799076 startingPage "281" @default.
- W2151799076 abstract "The urinary metabolites of 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT) in humans have been investigated by analyzing urine specimens from its users. For the unequivocal identification and accurate quantification of its major metabolites, careful analyses were conducted by gas chromatography/mass spectrometry, liquid chromatography/mass spectrometry, and liquid chromatography-tandem mass spectrometry, using authentic standards of each metabolite synthesized. Three major metabolic pathways were revealed as follows: 1) side chain degradation by O-demethylation to form 5-hydroxy-N,N-diisopropyltryptamine (5-OH-DIPT), which would be partly conjugated to its sulfate and glucuronide; 2) direct hydroxylation on position 6 of the aromatic ring of 5-MeO-DIPT, and/or methylation of the hydroxyl group on position 5 after hydroxylation on position 6 of the aromatic ring of 5-OH-DIPT, to produce 6-hydroxy-5-methoxy-N,N-diisopropyltryptamine (6-OH-5-MeO-DIPT), followed by conjugation to its sulfate and glucuronide; and 3) side chain degradation by N-deisopropylation, to the corresponding secondary amine 5-methoxy-N-isopropyltryptamine (5-MeO-NIPT). Of these metabolites, which retain structural characteristics of the parent drug, 5-OH-DIPT and 6-OH-5-MeO-DIPT were found to be more abundant than 5-MeO-NIPT. Although the parent drug 5-MeO-DIPT was detectable even 35 h after dosing, no trace of its N-oxide was detected in any of the specimens examined." @default.
- W2151799076 created "2016-06-24" @default.
- W2151799076 creator A5001781743 @default.
- W2151799076 creator A5005611021 @default.
- W2151799076 creator A5005961698 @default.
- W2151799076 creator A5006794632 @default.
- W2151799076 creator A5008694074 @default.
- W2151799076 creator A5009687500 @default.
- W2151799076 creator A5013343166 @default.
- W2151799076 creator A5064862242 @default.
- W2151799076 creator A5067718958 @default.
- W2151799076 creator A5085750226 @default.
- W2151799076 date "2005-11-09" @default.
- W2151799076 modified "2023-10-02" @default.
- W2151799076 title "METABOLISM OF THE PSYCHOTOMIMETIC TRYPTAMINE DERIVATIVE 5-METHOXY-<i>N</i>,<i>N</i>-DIISOPROPYLTRYPTAMINE IN HUMANS: IDENTIFICATION AND QUANTIFICATION OF ITS URINARY METABOLITES" @default.
- W2151799076 cites W2044222328 @default.
- W2151799076 cites W2077869015 @default.
- W2151799076 cites W2091588376 @default.
- W2151799076 cites W2093738439 @default.
- W2151799076 cites W2096695722 @default.
- W2151799076 cites W2103778139 @default.
- W2151799076 cites W2163648720 @default.
- W2151799076 doi "https://doi.org/10.1124/dmd.105.005835" @default.
- W2151799076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16280455" @default.
- W2151799076 hasPublicationYear "2005" @default.
- W2151799076 type Work @default.
- W2151799076 sameAs 2151799076 @default.
- W2151799076 citedByCount "47" @default.
- W2151799076 countsByYear W21517990762012 @default.
- W2151799076 countsByYear W21517990762013 @default.
- W2151799076 countsByYear W21517990762014 @default.
- W2151799076 countsByYear W21517990762015 @default.
- W2151799076 countsByYear W21517990762017 @default.
- W2151799076 countsByYear W21517990762019 @default.
- W2151799076 countsByYear W21517990762020 @default.
- W2151799076 countsByYear W21517990762021 @default.
- W2151799076 countsByYear W21517990762022 @default.
- W2151799076 countsByYear W21517990762023 @default.
- W2151799076 crossrefType "journal-article" @default.
- W2151799076 hasAuthorship W2151799076A5001781743 @default.
- W2151799076 hasAuthorship W2151799076A5005611021 @default.
- W2151799076 hasAuthorship W2151799076A5005961698 @default.
- W2151799076 hasAuthorship W2151799076A5006794632 @default.
- W2151799076 hasAuthorship W2151799076A5008694074 @default.
- W2151799076 hasAuthorship W2151799076A5009687500 @default.
- W2151799076 hasAuthorship W2151799076A5013343166 @default.
- W2151799076 hasAuthorship W2151799076A5064862242 @default.
- W2151799076 hasAuthorship W2151799076A5067718958 @default.
- W2151799076 hasAuthorship W2151799076A5085750226 @default.
- W2151799076 hasConcept C104317684 @default.
- W2151799076 hasConcept C150194340 @default.
- W2151799076 hasConcept C181199279 @default.
- W2151799076 hasConcept C185592680 @default.
- W2151799076 hasConcept C190727270 @default.
- W2151799076 hasConcept C202199734 @default.
- W2151799076 hasConcept C2777477808 @default.
- W2151799076 hasConcept C2779186261 @default.
- W2151799076 hasConcept C2781109383 @default.
- W2151799076 hasConcept C43617362 @default.
- W2151799076 hasConcept C55493867 @default.
- W2151799076 hasConcept C62231903 @default.
- W2151799076 hasConcept C71240020 @default.
- W2151799076 hasConceptScore W2151799076C104317684 @default.
- W2151799076 hasConceptScore W2151799076C150194340 @default.
- W2151799076 hasConceptScore W2151799076C181199279 @default.
- W2151799076 hasConceptScore W2151799076C185592680 @default.
- W2151799076 hasConceptScore W2151799076C190727270 @default.
- W2151799076 hasConceptScore W2151799076C202199734 @default.
- W2151799076 hasConceptScore W2151799076C2777477808 @default.
- W2151799076 hasConceptScore W2151799076C2779186261 @default.
- W2151799076 hasConceptScore W2151799076C2781109383 @default.
- W2151799076 hasConceptScore W2151799076C43617362 @default.
- W2151799076 hasConceptScore W2151799076C55493867 @default.
- W2151799076 hasConceptScore W2151799076C62231903 @default.
- W2151799076 hasConceptScore W2151799076C71240020 @default.
- W2151799076 hasIssue "2" @default.
- W2151799076 hasLocation W21517990761 @default.
- W2151799076 hasLocation W21517990762 @default.
- W2151799076 hasOpenAccess W2151799076 @default.
- W2151799076 hasPrimaryLocation W21517990761 @default.
- W2151799076 hasRelatedWork W1984431634 @default.
- W2151799076 hasRelatedWork W2020762097 @default.
- W2151799076 hasRelatedWork W2050986823 @default.
- W2151799076 hasRelatedWork W2051287293 @default.
- W2151799076 hasRelatedWork W2065017076 @default.
- W2151799076 hasRelatedWork W2127130326 @default.
- W2151799076 hasRelatedWork W2127666162 @default.
- W2151799076 hasRelatedWork W2319057482 @default.
- W2151799076 hasRelatedWork W2324115629 @default.
- W2151799076 hasRelatedWork W2994778318 @default.
- W2151799076 hasVolume "34" @default.
- W2151799076 isParatext "false" @default.
- W2151799076 isRetracted "false" @default.
- W2151799076 magId "2151799076" @default.
- W2151799076 workType "article" @default.