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• W2151802402 endingPage "1895" @default.
• W2151802402 startingPage "1885" @default.
• W2151802402 abstract "ABSTRACT Metal-dependent transcriptional regulators of the diphtheria toxin repressor (DtxR) family have been identified in a wide variety of bacterial genera, where they control gene expression in response to one of two metal ions, Fe 2+ or Mn 2+ . DtxR of Corynebacterium diphtheriae is the best characterized of these important metal-dependent regulators. The genus Corynebacterium includes many phenotypically diverse species, and the prevalence of DtxR-like regulators within the genus is unknown. We assayed chromosomal DNA from 42 different corynebacterial isolates, representing 33 different species, for the presence of a highly conserved region of the dtxR gene that encodes the DNA-binding helix-turn-helix motif and metal-binding site 1 within domains 1 and 2 of DtxR. The chromosome of all of the isolates contained this conserved region of dtxR , and DNA sequencing revealed a high level of nucleotide sequence conservation within this region in all of the corynebacterial species (ranging from 62 to 100% identity and averaging 70% identity with the dtxR prototype). The level of identity was even greater for the predicted protein sequences encoded by the dtxR -like genes, ranging from 81 to 100% identity and averaging 91% identity with DtxR. Using a DtxR-specific antiserum we confirmed the presence of a DtxR-like protein in extracts of most of the corynebacterial isolates and determined the precise amount of DtxR per cell in C. diphtheriae . The high level of identity at both DNA and protein levels suggests that all of the isolates tested encode a functional DtxR-like Fe 2+ -activated regulatory protein that can bind homologs of the DtxR operator and regulate gene expression in response to iron." @default.
• W2151802402 created "2016-06-24" @default.
• W2151802402 creator A5051273903 @default.
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• W2151802402 date "2004-04-01" @default.
• W2151802402 modified "2023-10-18" @default.
• W2151802402 title "Analysis of Genes That Encode DtxR-Like Transcriptional Regulators in Pathogenic and Saprophytic Corynebacterial Species" @default.
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• W2151802402 doi "https://doi.org/10.1128/iai.72.4.1885-1895.2004" @default.
• W2151802402 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/375144" @default.
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