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• W2151805562 endingPage "e1000787" @default.
• W2151805562 startingPage "e1000787" @default.
• W2151805562 abstract "Circadian pacemakers are essential to synchronize animal physiology and behavior with the dayrationight cycle. They are self-sustained, but the phase of their oscillations is determined by environmental cues, particularly light intensity and temperature cycles. In Drosophila, light is primarily detected by a dedicated blue-light photoreceptor: CRYPTOCHROME (CRY). Upon light activation, CRY binds to the pacemaker protein TIMELESS (TIM) and triggers its proteasomal degradation, thus resetting the circadian pacemaker. To understand further the CRY input pathway, we conducted a misexpression screen under constant light based on the observation that flies with a disruption in the CRY input pathway remain robustly rhythmic instead of becoming behaviorally arrhythmic. We report the identification of more than 20 potential regulators of CRY-dependent light responses. We demonstrate that one of them, the chromatin-remodeling enzyme KISMET (KIS), is necessary for normal circadian photoresponses, but does not affect the circadian pacemaker. KIS genetically interacts with CRY and functions in PDF-negative circadian neurons, which play an important role in circadian light responses. It also affects daily CRY-dependent TIM oscillations in a peripheral tissue: the eyes. We therefore conclude that KIS is a key transcriptional regulator of genes that function in the CRY signaling cascade, and thus it plays an important role in the synchronization of circadian rhythms with the dayrationight cycle." @default.
• W2151805562 created "2016-06-24" @default.
• W2151805562 creator A5035087788 @default.
• W2151805562 creator A5068402917 @default.
• W2151805562 creator A5080411693 @default.
• W2151805562 creator A5080717393 @default.
• W2151805562 date "2009-12-24" @default.
• W2151805562 modified "2023-10-16" @default.
• W2151805562 title "A Constant Light-Genetic Screen Identifies KISMET as a Regulator of Circadian Photoresponses" @default.
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• W2151805562 doi "https://doi.org/10.1371/journal.pgen.1000787" @default.
• W2151805562 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2789323" @default.
• W2151805562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20041201" @default.
• W2151805562 hasPublicationYear "2009" @default.
• W2151805562 type Work @default.
• W2151805562 sameAs 2151805562 @default.

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