FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2151810412> ?p ?o ?g. }

• W2151810412 endingPage "5383" @default.
• W2151810412 startingPage "5373" @default.
• W2151810412 abstract "ABSTRACT Transcription of mga , encoding the multiple virulence gene regulator of the group A streptococcus, is positively autoregulated. This regulation requires a DNA region (Pmga) that contains both a promoter proximal to mga (P2) and a promoter located further upstream (P1). To determine if Mga has a direct role in this process, its ability to bind to specific sequences within Pmga was tested. A purified fusion of Mga to the C-terminal end of maltose-binding protein (MBP-Mga), encoded by malE-mga , was shown previously to bind to the promoter regions of Mga-regulated genes, including scpA and emm . We report here that MBP-Mga can function in vivo to regulate emm and mga . Electrophoretic mobility shift assays and DNase I footprinting were used to demonstrate specific binding of MBP-Mga to two ca. 59-bp binding sites in Pmga centered around bases −108 and −180 from the major P2 start of transcription. Mga binding sites from Pemm and PscpA were shown to compete for binding at the two Pmga sites, suggesting that the same domain of Mga interacts at all of these promoter targets. Deletion of the distal Pmga binding site (site I) in vivo resulted in loss of Mga-dependent transcription from the P2 start. However, the same lesion resulted in an increase in P1 transcription that was independent of Mga. This suggests the existence of a repressor of mga transcription with a binding site overlapping those of Mga." @default.
• W2151810412 created "2016-06-24" @default.
• W2151810412 creator A5047272657 @default.
• W2151810412 creator A5054407781 @default.
• W2151810412 creator A5090847527 @default.
• W2151810412 date "1999-09-01" @default.
• W2151810412 modified "2023-09-29" @default.
• W2151810412 title "Regulation of <i>mga</i> Transcription in the Group A Streptococcus: Specific Binding of Mga within Its Own Promoter and Evidence for a Negative Regulator" @default.
• W2151810412 cites W1010047185 @default.
• W2151810412 cites W1510640610 @default.
• W2151810412 cites W1558516755 @default.
• W2151810412 cites W1562322570 @default.
• W2151810412 cites W1590824115 @default.
• W2151810412 cites W1685350997 @default.
• W2151810412 cites W1736256052 @default.
• W2151810412 cites W1825541953 @default.
• W2151810412 cites W1843970506 @default.
• W2151810412 cites W1918246416 @default.
• W2151810412 cites W1966236700 @default.
• W2151810412 cites W1977515340 @default.
• W2151810412 cites W1979589925 @default.
• W2151810412 cites W1989239167 @default.
• W2151810412 cites W2004709076 @default.
• W2151810412 cites W2027133166 @default.
• W2151810412 cites W2040401436 @default.
• W2151810412 cites W2044390926 @default.
• W2151810412 cites W2060045859 @default.
• W2151810412 cites W2060882081 @default.
• W2151810412 cites W2068999505 @default.
• W2151810412 cites W2074822534 @default.
• W2151810412 cites W2077077811 @default.
• W2151810412 cites W2079018293 @default.
• W2151810412 cites W2091109071 @default.
• W2151810412 cites W2097584347 @default.
• W2151810412 cites W2125107482 @default.
• W2151810412 cites W2138270253 @default.
• W2151810412 cites W2147849116 @default.
• W2151810412 cites W2151149762 @default.
• W2151810412 cites W2164073441 @default.
• W2151810412 cites W2222314715 @default.
• W2151810412 cites W4231807128 @default.
• W2151810412 doi "https://doi.org/10.1128/jb.181.17.5373-5383.1999" @default.
• W2151810412 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/94044" @default.
• W2151810412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10464209" @default.
• W2151810412 hasPublicationYear "1999" @default.
• W2151810412 type Work @default.
• W2151810412 sameAs 2151810412 @default.
• W2151810412 citedByCount "58" @default.
• W2151810412 countsByYear W21518104122012 @default.
• W2151810412 countsByYear W21518104122013 @default.
• W2151810412 countsByYear W21518104122014 @default.
• W2151810412 countsByYear W21518104122016 @default.
• W2151810412 countsByYear W21518104122017 @default.
• W2151810412 countsByYear W21518104122018 @default.
• W2151810412 countsByYear W21518104122020 @default.
• W2151810412 countsByYear W21518104122021 @default.
• W2151810412 countsByYear W21518104122022 @default.
• W2151810412 crossrefType "journal-article" @default.
• W2151810412 hasAuthorship W2151810412A5047272657 @default.
• W2151810412 hasAuthorship W2151810412A5054407781 @default.
• W2151810412 hasAuthorship W2151810412A5090847527 @default.
• W2151810412 hasBestOaLocation W21518104121 @default.
• W2151810412 hasConcept C101762097 @default.
• W2151810412 hasConcept C104317684 @default.
• W2151810412 hasConcept C107824862 @default.
• W2151810412 hasConcept C138885662 @default.
• W2151810412 hasConcept C150194340 @default.
• W2151810412 hasConcept C153911025 @default.
• W2151810412 hasConcept C158448853 @default.
• W2151810412 hasConcept C179926584 @default.
• W2151810412 hasConcept C22427896 @default.
• W2151810412 hasConcept C41895202 @default.
• W2151810412 hasConcept C54355233 @default.
• W2151810412 hasConcept C86339819 @default.
• W2151810412 hasConcept C86803240 @default.
• W2151810412 hasConcept C94966510 @default.
• W2151810412 hasConceptScore W2151810412C101762097 @default.
• W2151810412 hasConceptScore W2151810412C104317684 @default.
• W2151810412 hasConceptScore W2151810412C107824862 @default.
• W2151810412 hasConceptScore W2151810412C138885662 @default.
• W2151810412 hasConceptScore W2151810412C150194340 @default.
• W2151810412 hasConceptScore W2151810412C153911025 @default.
• W2151810412 hasConceptScore W2151810412C158448853 @default.
• W2151810412 hasConceptScore W2151810412C179926584 @default.
• W2151810412 hasConceptScore W2151810412C22427896 @default.
• W2151810412 hasConceptScore W2151810412C41895202 @default.
• W2151810412 hasConceptScore W2151810412C54355233 @default.
• W2151810412 hasConceptScore W2151810412C86339819 @default.
• W2151810412 hasConceptScore W2151810412C86803240 @default.
• W2151810412 hasConceptScore W2151810412C94966510 @default.
• W2151810412 hasIssue "17" @default.
• W2151810412 hasLocation W21518104121 @default.
• W2151810412 hasLocation W21518104122 @default.
• W2151810412 hasLocation W21518104123 @default.
• W2151810412 hasLocation W21518104124 @default.
• W2151810412 hasOpenAccess W2151810412 @default.
• W2151810412 hasPrimaryLocation W21518104121 @default.
• W2151810412 hasRelatedWork W1755517856 @default.

• next