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• W2151817307 abstract "TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) is a recently identified member of the tumor necrosis factor cytokine superfamily. TRAIL has been shown to induce apoptosis in various tumor cell lines, whereas most primary cells seem to be resistant. These observations have raised considerable interest in the use of TRAIL in tumor therapy. Yet little is known about the physiological function of TRAIL. This is particularly the case in the immune system, where TRAIL has been suggested by some to be involved in target cell killing and lymphocyte death. We have developed a panel of mAbs and soluble proteins to address the role of TRAIL in lymphocyte development. These studies demonstrate activation-induced sensitization of thymocytes to TRAIL-mediated apoptosis and expression of the apoptosis-inducing TRAIL receptors. However, with the use of several model systems, our subsequent experiments rule out the possibility that TRAIL plays a major role in antigen-induced deletion of thymocytes. In contrast to thymocytes, there is no up-regulation of TRAIL receptors in peripheral T cells on activation, which remain resistant to TRAIL. Thus, susceptibility to TRAIL-induced apoptosis is controlled differently by central and peripheral T cells." @default.
• W2151817307 created "2016-06-24" @default.
• W2151817307 creator A5005405638 @default.
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• W2151817307 creator A5085552716 @default.
• W2151817307 creator A5088147193 @default.
• W2151817307 date "2001-04-17" @default.
• W2151817307 modified "2023-09-23" @default.
• W2151817307 title "Tumor necrosis factor-related apoptosis-inducing ligand in T cell development: Sensitivity of human thymocytes" @default.
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• W2151817307 doi "https://doi.org/10.1073/pnas.091100398" @default.
• W2151817307 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/33180" @default.
• W2151817307 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11309507" @default.
• W2151817307 hasPublicationYear "2001" @default.
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