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• W2151835834 abstract "The Ca(2+)-sensitive dehydrogenases of the mitochondrial matrix are, so far, the only known effectors to allow Ca2+ signals to couple the activation of plasma membrane receptors to the stimulation of aerobic metabolism. In this study, we demonstrate a novel mechanism, based on Ca(2+)-sensitive metabolite carriers of the inner membrane. We expressed in Chinese hamster ovary cells aralar1 and citrin, aspartate/glutamate exchangers that have Ca(2+)-binding sites in their sequence, and measured mitochondrial Ca2+ and ATP levels as well as cytosolic Ca2+ concentration with targeted recombinant probes. The increase in mitochondrial ATP levels caused by cell stimulation with Ca(2+)-mobilizing agonists was markedly larger in cells expressing aralar and citrin (but not truncated mutants lacking the Ca(2+)-binding site) than in control cells. Conversely, the cytosolic and the mitochondrial Ca2+ signals were the same in control cells and cells expressing the different aralar1 and citrin variants, thus ruling out an indirect effect through the Ca(2+)-sensitive dehydrogenases. Together, these data show that the decoding of Ca2+ signals in mitochondria depends on the coordinate activity of mitochondrial enzymes and carriers, which may thus represent useful pharmacological targets in this process of major pathophysiological interest." @default.
• W2151835834 created "2016-06-24" @default.
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• W2151835834 date "2003-10-01" @default.
• W2151835834 modified "2023-10-12" @default.
• W2151835834 title "Recombinant Expression of the Ca2+-sensitive Aspartate/Glutamate Carrier Increases Mitochondrial ATP Production in Agonist-stimulated Chinese Hamster Ovary Cells" @default.
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• W2151835834 doi "https://doi.org/10.1074/jbc.m304988200" @default.
• W2151835834 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12851387" @default.
• W2151835834 hasPublicationYear "2003" @default.
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