Matches in SemOpenAlex for { <https://semopenalex.org/work/W2151837141> ?p ?o ?g. }
- W2151837141 endingPage "H1845" @default.
- W2151837141 startingPage "H1838" @default.
- W2151837141 abstract "alpha(2A)-Adrenergic receptors (ARs) in the midbrain regulate sympathetic nervous system activity, and both alpha(2A)-ARs and alpha(2C)-ARs regulate catecholamine release from sympathetic nerve terminals in cardiac tissue. Disruption of both alpha(2A)- and alpha(2C)-ARs in mice leads to chronically elevated sympathetic tone and decreased cardiac function by 4 mo of age. These knockout mice have increased mortality, reduced exercise capacity, decreased peak oxygen uptake, and decreased cardiac contractility relative to wild-type controls. Moreover, we observed significant abnormalities in the ultrastructure of cardiac myocytes from alpha(2A)/alpha(2C)-AR knockout mice by electron microscopy. Our results demonstrate that chronic elevation of sympathetic tone can lead to abnormal cardiac function in the absence of prior myocardial injury or genetically induced alterations in myocardial structural or functional proteins. These mice provide a physiologically relevant animal model for investigating the role of the sympathetic nervous system in the development and progression of heart failure." @default.
- W2151837141 created "2016-06-24" @default.
- W2151837141 creator A5010649243 @default.
- W2151837141 creator A5057606234 @default.
- W2151837141 creator A5072320472 @default.
- W2151837141 creator A5079682203 @default.
- W2151837141 creator A5090453270 @default.
- W2151837141 date "2002-11-01" @default.
- W2151837141 modified "2023-10-18" @default.
- W2151837141 title "Abnormal cardiac function associated with sympathetic nervous system hyperactivity in mice" @default.
- W2151837141 cites W1811826575 @default.
- W2151837141 cites W1950077991 @default.
- W2151837141 cites W1965393377 @default.
- W2151837141 cites W1965693810 @default.
- W2151837141 cites W1979004368 @default.
- W2151837141 cites W1982537841 @default.
- W2151837141 cites W1984193593 @default.
- W2151837141 cites W1988468898 @default.
- W2151837141 cites W1995538993 @default.
- W2151837141 cites W2002806885 @default.
- W2151837141 cites W2030826372 @default.
- W2151837141 cites W2032355065 @default.
- W2151837141 cites W2036325607 @default.
- W2151837141 cites W2068671266 @default.
- W2151837141 cites W2069478559 @default.
- W2151837141 cites W2075699728 @default.
- W2151837141 cites W2080202671 @default.
- W2151837141 cites W2080609613 @default.
- W2151837141 cites W2084235775 @default.
- W2151837141 cites W2087407895 @default.
- W2151837141 cites W2087750804 @default.
- W2151837141 cites W2094065595 @default.
- W2151837141 cites W2097149135 @default.
- W2151837141 cites W2097783955 @default.
- W2151837141 cites W2111598484 @default.
- W2151837141 cites W2112079413 @default.
- W2151837141 cites W2113934901 @default.
- W2151837141 cites W2117275809 @default.
- W2151837141 cites W2124101879 @default.
- W2151837141 cites W2134417114 @default.
- W2151837141 cites W2142377849 @default.
- W2151837141 cites W2146555288 @default.
- W2151837141 cites W2149495528 @default.
- W2151837141 cites W2149649063 @default.
- W2151837141 cites W2151355358 @default.
- W2151837141 cites W2156433522 @default.
- W2151837141 cites W2156995088 @default.
- W2151837141 cites W2157048650 @default.
- W2151837141 cites W2158800467 @default.
- W2151837141 cites W2167285355 @default.
- W2151837141 cites W2326657216 @default.
- W2151837141 doi "https://doi.org/10.1152/ajpheart.01063.2001" @default.
- W2151837141 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12384461" @default.
- W2151837141 hasPublicationYear "2002" @default.
- W2151837141 type Work @default.
- W2151837141 sameAs 2151837141 @default.
- W2151837141 citedByCount "90" @default.
- W2151837141 countsByYear W21518371412012 @default.
- W2151837141 countsByYear W21518371412013 @default.
- W2151837141 countsByYear W21518371412014 @default.
- W2151837141 countsByYear W21518371412015 @default.
- W2151837141 countsByYear W21518371412016 @default.
- W2151837141 countsByYear W21518371412017 @default.
- W2151837141 countsByYear W21518371412018 @default.
- W2151837141 countsByYear W21518371412019 @default.
- W2151837141 countsByYear W21518371412020 @default.
- W2151837141 countsByYear W21518371412021 @default.
- W2151837141 countsByYear W21518371412022 @default.
- W2151837141 crossrefType "journal-article" @default.
- W2151837141 hasAuthorship W2151837141A5010649243 @default.
- W2151837141 hasAuthorship W2151837141A5057606234 @default.
- W2151837141 hasAuthorship W2151837141A5072320472 @default.
- W2151837141 hasAuthorship W2151837141A5079682203 @default.
- W2151837141 hasAuthorship W2151837141A5090453270 @default.
- W2151837141 hasConcept C111566952 @default.
- W2151837141 hasConcept C126322002 @default.
- W2151837141 hasConcept C134018914 @default.
- W2151837141 hasConcept C158453852 @default.
- W2151837141 hasConcept C159110408 @default.
- W2151837141 hasConcept C169760540 @default.
- W2151837141 hasConcept C170493617 @default.
- W2151837141 hasConcept C182704531 @default.
- W2151837141 hasConcept C2775894120 @default.
- W2151837141 hasConcept C2775944032 @default.
- W2151837141 hasConcept C2776533406 @default.
- W2151837141 hasConcept C2777372248 @default.
- W2151837141 hasConcept C2777953023 @default.
- W2151837141 hasConcept C2778198053 @default.
- W2151837141 hasConcept C39133596 @default.
- W2151837141 hasConcept C40465926 @default.
- W2151837141 hasConcept C49453240 @default.
- W2151837141 hasConcept C529278444 @default.
- W2151837141 hasConcept C545706735 @default.
- W2151837141 hasConcept C552161191 @default.
- W2151837141 hasConcept C64943373 @default.
- W2151837141 hasConcept C71924100 @default.
- W2151837141 hasConcept C84393581 @default.
- W2151837141 hasConcept C86803240 @default.