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• W2151853725 abstract "No AccessJournal of UrologyClinical Urology: Original Article1 May 1996The Periurethral Glands do not Significantly Influence the Serum Prostate Specific Antigen Concentration Joseph E. Oesterling, Anita H. Tekchandani, Sandra K. Martin, Erik J. Bergstralh, Esther Reichstein, Eleftherios P. Diamandis, Cheryl Yemoto, and Thomas A. Stamey Joseph E. OesterlingJoseph E. Oesterling More articles by this author , Anita H. TekchandaniAnita H. Tekchandani More articles by this author , Sandra K. MartinSandra K. Martin More articles by this author , Erik J. BergstralhErik J. Bergstralh More articles by this author , Esther ReichsteinEsther Reichstein More articles by this author , Eleftherios P. DiamandisEleftherios P. Diamandis More articles by this author , Cheryl YemotoCheryl Yemoto More articles by this author , and Thomas A. StameyThomas A. Stamey More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)66156-1AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: The periurethral glands are known to produce prostate specific antigen (PSA). With ultra-sensitive assays now routinely available, it is necessary to determine if the periurethral glands significantly influence serum PSA concentration after radical prostatectomy. Materials and Methods: Serum PSA levels of 46 men, 51 to 89 years old (median age 67) who underwent radical cystoprostatectomy and total urethrectomy, were compared with those of 92 men 46 to 91 years old (median age 67) who underwent radical cystoprostatectomy only. All men had transitional cell carcinoma of the bladder without gross or microscopic evidence of prostate cancer and all underwent ileal conduit diversion. Serum was obtained at least 1 year postoperatively. Each specimen was analyzed using the Tosoh, [dagger] Immulite, [double dagger] and Yu and Diamandis ultra-sensitive PSA assays with analytical detection limits of 0.02 ng./ml., 0.004 ng./ml. and 0.002 ng./ml., respectively. [dagger] Tosoh Corp., Tokyo, Japan. [double dagger] Diagnostic Products Corp., Los Angeles, California. Results: Median PSA for the radical cystoprostatectomy with urethrectomy group was 0.00 ng./ml. (range 0.00 to 0.14) for each of the 3 assays. For the radical cystoprostatectomy only group the median Tosoh and Immulite PSA assay levels were 0.01 ng./ml. (range 0.00 to 0.22), and median Yu and Diamandis PSA assay level was 0.00 ng./ml. (range 0.00 to 0.31). Conclusions: The greatest difference in median PSA levels that could be found between men with and without periurethral glands when using 3 different ultra-sensitive assays was 0.01 ng./ml., indicating that the periurethral glands do not have a clinically significant effect on serum PSA concentration after radical prostatectomy. Thus, a serum PSA level above the residual cancer detection limit following radical prostatectomy, even if obtained with an ultra-sensitive assay, reflects either malignant or benign residual prostatic tissue, rather than the presence of periurethral glands. References 1 : An analysis of urinary prostate specific antigen before and after radical prostatectomy: evidence for secretion of prostate specific antigen by the periurethral glands. J. Urol1993; 149: 783. Link, Google Scholar 2 : Extraprostatic localization of prostatic acid phosphatase and prostate specific antigen: distribution in cloacogenic glandular epithelium and sex dependent expression in human anal gland. Hum. Path1990; 21: 1108. Google Scholar 3 : Immunoreactive prostatic specific antigen in male periurethral glands. J. Urol1992; 147: 246. Link, Google Scholar 4 : A comparison of 4 ultrasensitive prostate specific antigen assays for early detection of residual cancer after radical prostatectomy. J. Urol1994; 152: 1515. Link, Google Scholar 5 : A high sensitivity chemiluminescent immunoassay for prostatic specific antigen. Clin. Chem1994; 40: 162. Google Scholar 6 : Ultrasensitive time-resolved immunofluorometric assay of prostate-specific antigen in serum and preliminary clinical studies. Clin. Chem1993; 39: 2108. Google Scholar 7 : The clinical usefulness of prostate specific antigen: update 1994. J. Urol1994; 152: 1358. Link, Google Scholar 8 : Serum PSA after anatomic radical prostatectomy. The Johns Hopkins experience after 10 years. Urol. Clin. N. Amer1993; 20: 713. Crossref, Medline, Google Scholar 9 : Follow-up after radical prostatectomy or radiation therapy for prostate cancer. Urol. Clin. N. Amer1994; 21: 673. Google Scholar 10 : A brief review of ultrasensitive prostate-specific antigen assays for the evaluation of patients after radical prostatectomy. World J. Urol1993; 11: 192. Google Scholar 11 : The enhanced detection of persistent disease after prostatectomy with a new prostate specific antigen immunoassay. J. Urol1993; 150: 374. Link, Google Scholar Michigan Prostate Institute and University of Michigan, Ann Arbor, Michigan, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, Diagnostic Products Corporation, Los Angeles and Stanford University, Stanford, California, and Mount Sinai Hospital, Toronto, Ontario, Canada.© 1996 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byTilki D, Kim S, Hu B, Dall’Era M and Evans C (2014) Ultrasensitive Prostate Specific Antigen and its Role after Radical Prostatectomy: A Systematic ReviewJournal of Urology, VOL. 193, NO. 5, (1525-1531), Online publication date: 1-May-2015. Volume 155Issue 5May 1996Page: 1658-1660 Advertisement Copyright & Permissions© 1996 by American Urological Association, Inc.MetricsAuthor Information Joseph E. Oesterling More articles by this author Anita H. Tekchandani More articles by this author Sandra K. Martin More articles by this author Erik J. Bergstralh More articles by this author Esther Reichstein More articles by this author Eleftherios P. Diamandis More articles by this author Cheryl Yemoto More articles by this author Thomas A. Stamey More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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