FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2151854014> ?p ?o ?g. }

• W2151854014 endingPage "212" @default.
• W2151854014 startingPage "200" @default.
• W2151854014 abstract "The traditional view, based primarily on X-ray crystallographic data, is that the amino acid residues at positions B12, B16, B23-B26, A1-A5, A19 and A21 in the insulin molecule comprise the receptor-binding domain. More recently, however, it has been proposed that the conformation adopted by insulin in the crystal structure is an inactive one. The results of alanine-scanning mutagenesis studies suggest that GlyB23, PheB24, IleA2, ValA3, and TyrA19 interact directly with the receptor with LeuB6, GlyB8, LeuB11, GluB13 and PheB25, although not part of the binding epitope, being important in maintaining the receptor-binding conformation. A comparison of the primary structures of insulins from a wide range of non-mammalian vertebrates, from hagfish to birds, provides support for this revised view by demonstrating that strong evolutionary pressure has acted to conserve those amino acids postulated to be important in the biologically active conformation. In addition to the cysteine residues, the amino acids at B6, B8, B11, B23, B24, A2, A3, and A19 are invariant in all species yet studied with only conservative substitutions (Glu → Asp) at B13 and (Phe → Tyr) at B25. In contrast, several insulins containing substitutions at positions B16, A5 and A21, sites of importance in maintaining the crystal structure conformation, have been identified. Although the amino acid sequences of insulin are not generally useful as molecular markers for inferring phylogenetic relationships between species, the presence of common structural features in insulins from closely related species may permit a valid inference. For example, the presence of an N-terminal pentapeptide extension to the B-chains of insulins isolated from both holarctic and southern hemisphere lampreys supports the monophyletic status of the Petromyzontiformes." @default.
• W2151854014 created "2016-06-24" @default.
• W2151854014 creator A5021521139 @default.
• W2151854014 date "2000-04-01" @default.
• W2151854014 modified "2023-10-17" @default.
• W2151854014 title "Molecular Evolution of Insulin in Non-Mammalian Vertebrates1" @default.
• W2151854014 cites W122168674 @default.
• W2151854014 cites W1515799994 @default.
• W2151854014 cites W1937983574 @default.
• W2151854014 cites W1971782599 @default.
• W2151854014 cites W1976822387 @default.
• W2151854014 cites W1994946766 @default.
• W2151854014 cites W2002831678 @default.
• W2151854014 cites W2009965902 @default.
• W2151854014 cites W2014942526 @default.
• W2151854014 cites W2015102083 @default.
• W2151854014 cites W2015562528 @default.
• W2151854014 cites W2026241102 @default.
• W2151854014 cites W2033836903 @default.
• W2151854014 cites W2036295745 @default.
• W2151854014 cites W2038224113 @default.
• W2151854014 cites W2053795827 @default.
• W2151854014 cites W2057144979 @default.
• W2151854014 cites W2064039538 @default.
• W2151854014 cites W2064352058 @default.
• W2151854014 cites W2072960270 @default.
• W2151854014 cites W2077630059 @default.
• W2151854014 cites W2093433342 @default.
• W2151854014 cites W2094642019 @default.
• W2151854014 cites W2110720514 @default.
• W2151854014 cites W2118515413 @default.
• W2151854014 cites W2122701269 @default.
• W2151854014 cites W2128704579 @default.
• W2151854014 cites W2129160647 @default.
• W2151854014 cites W2142699878 @default.
• W2151854014 cites W2147546529 @default.
• W2151854014 cites W2149556434 @default.
• W2151854014 cites W2156301127 @default.
• W2151854014 cites W2161258436 @default.
• W2151854014 cites W4240736285 @default.
• W2151854014 cites W964503500 @default.
• W2151854014 doi "https://doi.org/10.1668/0003-1569(2000)040[0200:meoiin]2.0.co;2" @default.
• W2151854014 hasPublicationYear "2000" @default.
• W2151854014 type Work @default.
• W2151854014 sameAs 2151854014 @default.
• W2151854014 citedByCount "29" @default.
• W2151854014 countsByYear W21518540142012 @default.
• W2151854014 countsByYear W21518540142013 @default.
• W2151854014 countsByYear W21518540142015 @default.
• W2151854014 countsByYear W21518540142018 @default.
• W2151854014 countsByYear W21518540142020 @default.
• W2151854014 crossrefType "journal-article" @default.
• W2151854014 hasAuthorship W2151854014A5021521139 @default.
• W2151854014 hasBestOaLocation W21518540142 @default.
• W2151854014 hasConcept C169627665 @default.
• W2151854014 hasConcept C181199279 @default.
• W2151854014 hasConcept C185592680 @default.
• W2151854014 hasConcept C2779856020 @default.
• W2151854014 hasConcept C515207424 @default.
• W2151854014 hasConcept C55493867 @default.
• W2151854014 hasConcept C71240020 @default.
• W2151854014 hasConcept C86803240 @default.
• W2151854014 hasConceptScore W2151854014C169627665 @default.
• W2151854014 hasConceptScore W2151854014C181199279 @default.
• W2151854014 hasConceptScore W2151854014C185592680 @default.
• W2151854014 hasConceptScore W2151854014C2779856020 @default.
• W2151854014 hasConceptScore W2151854014C515207424 @default.
• W2151854014 hasConceptScore W2151854014C55493867 @default.
• W2151854014 hasConceptScore W2151854014C71240020 @default.
• W2151854014 hasConceptScore W2151854014C86803240 @default.
• W2151854014 hasIssue "2" @default.
• W2151854014 hasLocation W21518540141 @default.
• W2151854014 hasLocation W21518540142 @default.
• W2151854014 hasOpenAccess W2151854014 @default.
• W2151854014 hasPrimaryLocation W21518540141 @default.
• W2151854014 hasRelatedWork W1990758898 @default.
• W2151854014 hasRelatedWork W1997322256 @default.
• W2151854014 hasRelatedWork W2014288004 @default.
• W2151854014 hasRelatedWork W2044257351 @default.
• W2151854014 hasRelatedWork W2058685556 @default.
• W2151854014 hasRelatedWork W2080181011 @default.
• W2151854014 hasRelatedWork W2117261940 @default.
• W2151854014 hasRelatedWork W2170754052 @default.
• W2151854014 hasRelatedWork W4323248528 @default.
• W2151854014 hasRelatedWork W2065660933 @default.
• W2151854014 hasVolume "40" @default.
• W2151854014 isParatext "false" @default.
• W2151854014 isRetracted "false" @default.
• W2151854014 magId "2151854014" @default.
• W2151854014 workType "article" @default.