FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2151875934> ?p ?o ?g. }

• W2151875934 endingPage "481" @default.
• W2151875934 startingPage "477" @default.
• W2151875934 abstract "Genetic variants of IL-18 and IL-12B may be important in immunoregulatory abnormalities, observed in the patients with Type 1 diabetes mellitus (T1DM), that contribute to individual differences in response to a treatment. Therefore, we examined the significance of IL-18-137G/C, IL-18-607C/A, and IL-12B A/C polymorphisms in Croatians (187 patients, 236 controls), not only as factors that contribute to susceptibility to T1DM, but also as determinants of the clinical presentation of disease. The polymorphism screening has been performed using PCR sequence-specific primers (IL-18) or PCR-RFLP (IL-12B) approach. Results were evaluated by GraphPad Prism and Sigma Stat 3.5, Arlequin software and calculator for Hardy-Weinberg equilibrium. The genotype, allele and haplotype distribution were not statistically different between the patients and control subjects. The clinical parameter analysis revealed that patients with minor alleles at each locus, IL-18-137C/-607A, were significantly younger at T1DM onset than carriers of major alleles, IL-18-137G/-607C (20 vs 23.5 years). Moreover, the concomitant presence of minor alleles not only of IL-18 but also of IL-12B, is associated with the risk of disease progression even at younger age. These patients developed diabetes at 16 years of age, what is significantly earlier (p=0.044) compared to 25.5 years of age in patients with common alleles IL-18-137G/-607C/IL-12B A. Furthermore, combined genotype analysis of IL-18 and IL-12B has pointed out that patients with CC/AA/AA genotype have the worst glucose control based on HbA1c (8.7%, range 6.8-13.1%). In conclusion, susceptibility to T1DM in Croatians is not strongly associated with IL-18-137/-607 and IL-12B polymorphisms. These SNPs are associated with the higher risk of earlier disease development and might be implicated in the effectiveness of glycemic control." @default.
• W2151875934 created "2016-06-24" @default.
• W2151875934 creator A5021911110 @default.
• W2151875934 creator A5027988673 @default.
• W2151875934 creator A5028114346 @default.
• W2151875934 creator A5042143289 @default.
• W2151875934 creator A5045821123 @default.
• W2151875934 creator A5074480522 @default.
• W2151875934 date "2013-01-01" @default.
• W2151875934 modified "2023-09-25" @default.
• W2151875934 title "Polymorphisms in the IL-18 and IL-12B genes and their association with the clinical outcome in Croatian patients with Type 1 diabetes" @default.
• W2151875934 cites W1499666021 @default.
• W2151875934 cites W1501206772 @default.
• W2151875934 cites W1576070276 @default.
• W2151875934 cites W1960747349 @default.
• W2151875934 cites W1966140319 @default.
• W2151875934 cites W1968766344 @default.
• W2151875934 cites W1973684956 @default.
• W2151875934 cites W1986298355 @default.
• W2151875934 cites W1995684257 @default.
• W2151875934 cites W1999317689 @default.
• W2151875934 cites W2008335027 @default.
• W2151875934 cites W2012818318 @default.
• W2151875934 cites W2014940064 @default.
• W2151875934 cites W2026161448 @default.
• W2151875934 cites W2047728316 @default.
• W2151875934 cites W2053576831 @default.
• W2151875934 cites W2056843503 @default.
• W2151875934 cites W2076854360 @default.
• W2151875934 cites W2079004268 @default.
• W2151875934 cites W2085281899 @default.
• W2151875934 cites W2086196933 @default.
• W2151875934 cites W2088685382 @default.
• W2151875934 cites W2099936444 @default.
• W2151875934 cites W2100601311 @default.
• W2151875934 cites W2101384717 @default.
• W2151875934 cites W2113425166 @default.
• W2151875934 cites W2117139202 @default.
• W2151875934 cites W2118094114 @default.
• W2151875934 cites W2118546838 @default.
• W2151875934 cites W2124723771 @default.
• W2151875934 cites W2134375936 @default.
• W2151875934 cites W2135424904 @default.
• W2151875934 cites W2141687336 @default.
• W2151875934 cites W2166037275 @default.
• W2151875934 cites W2168331207 @default.
• W2151875934 cites W2324858983 @default.
• W2151875934 cites W4313310005 @default.
• W2151875934 doi "https://doi.org/10.1016/j.gene.2012.10.029" @default.
• W2151875934 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23137633" @default.
• W2151875934 hasPublicationYear "2013" @default.
• W2151875934 type Work @default.
• W2151875934 sameAs 2151875934 @default.
• W2151875934 citedByCount "14" @default.
• W2151875934 countsByYear W21518759342013 @default.
• W2151875934 countsByYear W21518759342015 @default.
• W2151875934 countsByYear W21518759342016 @default.
• W2151875934 countsByYear W21518759342017 @default.
• W2151875934 countsByYear W21518759342018 @default.
• W2151875934 countsByYear W21518759342019 @default.
• W2151875934 countsByYear W21518759342020 @default.
• W2151875934 countsByYear W21518759342021 @default.
• W2151875934 countsByYear W21518759342023 @default.
• W2151875934 crossrefType "journal-article" @default.
• W2151875934 hasAuthorship W2151875934A5021911110 @default.
• W2151875934 hasAuthorship W2151875934A5027988673 @default.
• W2151875934 hasAuthorship W2151875934A5028114346 @default.
• W2151875934 hasAuthorship W2151875934A5042143289 @default.
• W2151875934 hasAuthorship W2151875934A5045821123 @default.
• W2151875934 hasAuthorship W2151875934A5074480522 @default.
• W2151875934 hasConcept C104317684 @default.
• W2151875934 hasConcept C126322002 @default.
• W2151875934 hasConcept C134018914 @default.
• W2151875934 hasConcept C135763542 @default.
• W2151875934 hasConcept C149737253 @default.
• W2151875934 hasConcept C157410074 @default.
• W2151875934 hasConcept C180754005 @default.
• W2151875934 hasConcept C197754878 @default.
• W2151875934 hasConcept C203014093 @default.
• W2151875934 hasConcept C2778690821 @default.
• W2151875934 hasConcept C2779134260 @default.
• W2151875934 hasConcept C2781232474 @default.
• W2151875934 hasConcept C37463918 @default.
• W2151875934 hasConcept C54355233 @default.
• W2151875934 hasConcept C555293320 @default.
• W2151875934 hasConcept C68239362 @default.
• W2151875934 hasConcept C71924100 @default.
• W2151875934 hasConcept C84597430 @default.
• W2151875934 hasConcept C86803240 @default.
• W2151875934 hasConceptScore W2151875934C104317684 @default.
• W2151875934 hasConceptScore W2151875934C126322002 @default.
• W2151875934 hasConceptScore W2151875934C134018914 @default.
• W2151875934 hasConceptScore W2151875934C135763542 @default.
• W2151875934 hasConceptScore W2151875934C149737253 @default.
• W2151875934 hasConceptScore W2151875934C157410074 @default.
• W2151875934 hasConceptScore W2151875934C180754005 @default.
• W2151875934 hasConceptScore W2151875934C197754878 @default.
• W2151875934 hasConceptScore W2151875934C203014093 @default.

• next