Matches in SemOpenAlex for { <https://semopenalex.org/work/W2151920005> ?p ?o ?g. }
- W2151920005 endingPage "1007" @default.
- W2151920005 startingPage "998" @default.
- W2151920005 abstract "The prototypic foot-and-mouth disease virus (FMDV) was shown more than a century ago to be the first filterable agent capable of causing FMD, and it has served as an important model for studying basic principles of Aphthovirus molecular biology. However, the complex structure and antigenic diversity of FMDV have posed a major obstacle to the attempts at manipulating the infectious virus by reverse genetic techniques. Here, we report the recovery of infectious FMDV from cDNAs based on an efficient in vivo RNA polymerase I (polI) transcription system. Intracellular transcription of the full-length viral genome from polI-based vectors resulted in efficient formation of infectious virus displaying a genetic marker. Compared with wild-type virus, an abundance of genomic mRNA and elevated expression levels of viral antigens were indicative of the hyperfunction throughout the life-cycle of this cDNA-derived virus at transcription, replication, and translation levels. The technology described here could be an extremely valuable molecular biology tool for studying FMDV complex infectious characteristics. It is an operating platform for studying FMDV functional genomics, molecular mechanism of pathogenicity and variation, and lays a solid foundation for the development of viral chimeras toward the prospect of a genetically engineered vaccine." @default.
- W2151920005 created "2016-06-24" @default.
- W2151920005 creator A5004724569 @default.
- W2151920005 creator A5006869577 @default.
- W2151920005 creator A5015568621 @default.
- W2151920005 creator A5026349233 @default.
- W2151920005 creator A5042855183 @default.
- W2151920005 creator A5077149100 @default.
- W2151920005 creator A5081183372 @default.
- W2151920005 date "2009-12-01" @default.
- W2151920005 modified "2023-10-18" @default.
- W2151920005 title "Recovery of infectious foot-and-mouth disease virus from full-length genomic cDNA clones using an RNA polymerase I system" @default.
- W2151920005 cites W1519227646 @default.
- W2151920005 cites W1549084454 @default.
- W2151920005 cites W1938043974 @default.
- W2151920005 cites W1942807013 @default.
- W2151920005 cites W1969118676 @default.
- W2151920005 cites W1972659397 @default.
- W2151920005 cites W1974363716 @default.
- W2151920005 cites W1975491920 @default.
- W2151920005 cites W1989988154 @default.
- W2151920005 cites W1993348039 @default.
- W2151920005 cites W1996319830 @default.
- W2151920005 cites W1998405235 @default.
- W2151920005 cites W1998983118 @default.
- W2151920005 cites W2005108546 @default.
- W2151920005 cites W2011576974 @default.
- W2151920005 cites W2025401269 @default.
- W2151920005 cites W2025770704 @default.
- W2151920005 cites W2056142982 @default.
- W2151920005 cites W2062067897 @default.
- W2151920005 cites W2071460423 @default.
- W2151920005 cites W2078587242 @default.
- W2151920005 cites W2087068983 @default.
- W2151920005 cites W2089238196 @default.
- W2151920005 cites W2089561176 @default.
- W2151920005 cites W2095146034 @default.
- W2151920005 cites W2096190714 @default.
- W2151920005 cites W2100701307 @default.
- W2151920005 cites W2103738533 @default.
- W2151920005 cites W2107277218 @default.
- W2151920005 cites W2114329037 @default.
- W2151920005 cites W2119131783 @default.
- W2151920005 cites W2119726128 @default.
- W2151920005 cites W2120638695 @default.
- W2151920005 cites W2132259935 @default.
- W2151920005 cites W2133106116 @default.
- W2151920005 cites W2136459673 @default.
- W2151920005 cites W2154001209 @default.
- W2151920005 cites W2155708590 @default.
- W2151920005 cites W2157484446 @default.
- W2151920005 cites W2162661448 @default.
- W2151920005 cites W2324228265 @default.
- W2151920005 doi "https://doi.org/10.1093/abbs/gmp093" @default.
- W2151920005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20011974" @default.
- W2151920005 hasPublicationYear "2009" @default.
- W2151920005 type Work @default.
- W2151920005 sameAs 2151920005 @default.
- W2151920005 citedByCount "14" @default.
- W2151920005 countsByYear W21519200052012 @default.
- W2151920005 countsByYear W21519200052013 @default.
- W2151920005 countsByYear W21519200052014 @default.
- W2151920005 countsByYear W21519200052015 @default.
- W2151920005 countsByYear W21519200052016 @default.
- W2151920005 countsByYear W21519200052021 @default.
- W2151920005 countsByYear W21519200052023 @default.
- W2151920005 crossrefType "journal-article" @default.
- W2151920005 hasAuthorship W2151920005A5004724569 @default.
- W2151920005 hasAuthorship W2151920005A5006869577 @default.
- W2151920005 hasAuthorship W2151920005A5015568621 @default.
- W2151920005 hasAuthorship W2151920005A5026349233 @default.
- W2151920005 hasAuthorship W2151920005A5042855183 @default.
- W2151920005 hasAuthorship W2151920005A5077149100 @default.
- W2151920005 hasAuthorship W2151920005A5081183372 @default.
- W2151920005 hasBestOaLocation W21519200051 @default.
- W2151920005 hasConcept C104317684 @default.
- W2151920005 hasConcept C138885662 @default.
- W2151920005 hasConcept C140704245 @default.
- W2151920005 hasConcept C141231307 @default.
- W2151920005 hasConcept C159047783 @default.
- W2151920005 hasConcept C179926584 @default.
- W2151920005 hasConcept C187882448 @default.
- W2151920005 hasConcept C2522874641 @default.
- W2151920005 hasConcept C25365240 @default.
- W2151920005 hasConcept C2776151397 @default.
- W2151920005 hasConcept C2779102375 @default.
- W2151920005 hasConcept C41895202 @default.
- W2151920005 hasConcept C54355233 @default.
- W2151920005 hasConcept C67705224 @default.
- W2151920005 hasConcept C86803240 @default.
- W2151920005 hasConceptScore W2151920005C104317684 @default.
- W2151920005 hasConceptScore W2151920005C138885662 @default.
- W2151920005 hasConceptScore W2151920005C140704245 @default.
- W2151920005 hasConceptScore W2151920005C141231307 @default.
- W2151920005 hasConceptScore W2151920005C159047783 @default.
- W2151920005 hasConceptScore W2151920005C179926584 @default.
- W2151920005 hasConceptScore W2151920005C187882448 @default.
- W2151920005 hasConceptScore W2151920005C2522874641 @default.