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- W2151930658 startingPage "147" @default.
- W2151930658 abstract "Acetaminophen and pulegone are just two examples for many agents that can form reactive metabolites that can cause acute liver injury. Two other classic organic compounds that have been extensively studied are carbon tetrachloride (for a recent review see Ref. 159, and for other discussions see Refs. 8 and 9) and bromobenzene (for review see Ref. 160). Different kinds of protein adducts of reactive metabolites of bromobenzene have been partially characterized [161], and specific antibodies to these adducts are now being used to isolate and identify the proteins that are modified (162). In contrast, carbon tetrachloride and other agents, such as the herbicide diquat, may form radicals that bind to and/or oxidize lipids and proteins in causing liver injury (163, 164). Therefore, the recent development [165] of antibodies to detect oxidative damage to proteins will be important in the identification and characterization of macromolecules that do not form adducts with reactive metabolites but are damaged oxidatively. Thus, some major challenges in the coming years are to identify hepatocellular macromolecules that are modified by reactive metabolites, and then approach the more difficult task of integrating this information into a time course and sequence of events leading to lethal hepatocellular injury." @default.
- W2151930658 created "2016-06-24" @default.
- W2151930658 creator A5087288886 @default.
- W2151930658 date "1995-01-01" @default.
- W2151930658 modified "2023-10-16" @default.
- W2151930658 title "Mechanisms of the Formation and Disposition of Reactive Metabolites That can Cause Acute Liver Injury" @default.
- W2151930658 cites W1482264334 @default.
- W2151930658 cites W1491720445 @default.
- W2151930658 cites W1525487916 @default.
- W2151930658 cites W1586179871 @default.
- W2151930658 cites W1591689230 @default.
- W2151930658 cites W1592028829 @default.
- W2151930658 cites W1609961433 @default.
- W2151930658 cites W1927749662 @default.
- W2151930658 cites W1964670176 @default.
- W2151930658 cites W1964873076 @default.
- W2151930658 cites W1966991584 @default.
- W2151930658 cites W1967684747 @default.
- W2151930658 cites W1968211769 @default.
- W2151930658 cites W1968803178 @default.
- W2151930658 cites W1969754605 @default.
- W2151930658 cites W1970931592 @default.
- W2151930658 cites W1971296064 @default.
- W2151930658 cites W1973483019 @default.
- W2151930658 cites W1977495682 @default.
- W2151930658 cites W1978796264 @default.
- W2151930658 cites W1979655360 @default.
- W2151930658 cites W1979916265 @default.
- W2151930658 cites W1979997292 @default.
- W2151930658 cites W1982800694 @default.
- W2151930658 cites W1982802663 @default.
- W2151930658 cites W1984734797 @default.
- W2151930658 cites W1984831176 @default.
- W2151930658 cites W1986874594 @default.
- W2151930658 cites W1987945561 @default.
- W2151930658 cites W1989640442 @default.
- W2151930658 cites W1991621876 @default.
- W2151930658 cites W1993000573 @default.
- W2151930658 cites W1994032728 @default.
- W2151930658 cites W1996641704 @default.
- W2151930658 cites W1996984062 @default.
- W2151930658 cites W1997610850 @default.
- W2151930658 cites W1998176243 @default.
- W2151930658 cites W2000911040 @default.
- W2151930658 cites W2001369456 @default.
- W2151930658 cites W2001374117 @default.
- W2151930658 cites W2002189467 @default.
- W2151930658 cites W2003040266 @default.
- W2151930658 cites W2003946693 @default.
- W2151930658 cites W2004675054 @default.
- W2151930658 cites W2006681962 @default.
- W2151930658 cites W2006810391 @default.
- W2151930658 cites W2007288928 @default.
- W2151930658 cites W2008129676 @default.
- W2151930658 cites W2008857800 @default.
- W2151930658 cites W2013832046 @default.
- W2151930658 cites W2017246842 @default.
- W2151930658 cites W2017570609 @default.
- W2151930658 cites W2018683888 @default.
- W2151930658 cites W2019479221 @default.
- W2151930658 cites W2020850424 @default.
- W2151930658 cites W2022687975 @default.
- W2151930658 cites W2025842042 @default.
- W2151930658 cites W2026053667 @default.
- W2151930658 cites W2027080882 @default.
- W2151930658 cites W2027098751 @default.
- W2151930658 cites W2031713954 @default.
- W2151930658 cites W2033132686 @default.
- W2151930658 cites W2033618502 @default.
- W2151930658 cites W2037863842 @default.
- W2151930658 cites W2041281943 @default.
- W2151930658 cites W2041462223 @default.
- W2151930658 cites W2042948151 @default.
- W2151930658 cites W2045981977 @default.
- W2151930658 cites W2048261520 @default.
- W2151930658 cites W2049474323 @default.
- W2151930658 cites W2049849453 @default.
- W2151930658 cites W2052783402 @default.
- W2151930658 cites W2059485107 @default.
- W2151930658 cites W2060741761 @default.
- W2151930658 cites W2060961865 @default.
- W2151930658 cites W2061202162 @default.
- W2151930658 cites W2063337484 @default.
- W2151930658 cites W2065227007 @default.
- W2151930658 cites W2067816697 @default.
- W2151930658 cites W2068420451 @default.
- W2151930658 cites W2069465010 @default.
- W2151930658 cites W2071183868 @default.
- W2151930658 cites W2072036318 @default.
- W2151930658 cites W2074965404 @default.
- W2151930658 cites W2075467523 @default.
- W2151930658 cites W2075836372 @default.
- W2151930658 cites W2077083094 @default.
- W2151930658 cites W2077866814 @default.
- W2151930658 cites W2078168582 @default.
- W2151930658 cites W2078808118 @default.
- W2151930658 cites W2079356413 @default.
- W2151930658 cites W2081970049 @default.