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• W2151941036 abstract "Abstract. The effects of ampicillin, clindamycin or metronidazole, given perorally for 6 days to eighteen healthy volunteers, upon the following intestinal microflora-associated characteristics (MACs) were evaluated: breakdown of mucin, formation of coprostanol, hydrolysis of bilirubin conjugates, formation of urobilinogen, and of some short chain fatty acids (SCFAs), presence of β-aspartylglycine and inactivation of trypsin. Clindamycin markedly influenced the expression of all characteristics, but trypsin and β-aspartylglycine, resulting in a pattern very much alike what has been found in germ-free animals. Ampicillin caused a significant reduction in total amount of SCFAs (P<0·05) and urobilinogen (P<0·05) present in the faecal samples. Metronidazole caused a significant reduction in the formation of coprostanol and the deconjugation of bilirubin (P<0·05). We conclude that orally given antibiotics may cause major alterations in several parameters reflecting the normal biotransformatory activity of the intestinal microflora, probably caused by severe disturbances in the intestinal ecosystem." @default.
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• W2151941036 date "1986-02-01" @default.
• W2151941036 modified "2023-10-18" @default.
• W2151941036 title "Influence of peroral antibiotics upon the biotransformatory activity of the intestinal microflora in healthy subjects" @default.
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• W2151941036 doi "https://doi.org/10.1111/j.1365-2362.1986.tb01300.x" @default.
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