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• W2151941372 abstract "The Sec translocon constitutes a ubiquitous protein transport channel that consists in bacteria of the three core components: SecY, SecE, and SecG. Additional proteins interact with SecYEG during different stages of protein transport. During targeting, SecYEG interacts with SecA, the SRP receptor, or the ribosome. Protein transport into or across the membrane is then facilitated by the interaction of SecYEG with YidC and the SecDFYajC complex. During protein transport, SecYEG is likely to interact also with the protein quality control machinery, but details about this interaction are missing. By in vivo and in vitro site-directed cross-linking, we show here that the periplasmic chaperone PpiD is located in front of the lateral gate of SecY, through which transmembrane domains exit the SecY channel. The strongest contacts were found to helix 2b of SecY. Blue native PAGE analyses verify the presence of a SecYEG-PpiD complex in native Escherichia coli membranes. The PpiD-SecY interaction was not influenced by the addition of SecA and only weakly influenced by binding of nontranslating ribosomes to SecYEG. In contrast, PpiD lost contact to the lateral gate of SecY during membrane protein insertion. These data identify PpiD as an additional and transient subunit of the bacterial SecYEG translocon. The data furthermore demonstrate the highly modular and versatile composition of the Sec translocon, which is probably essential for its ability to transport a wide range of substrates across membranes in bacteria and eukaryotes." @default.
• W2151941372 created "2016-06-24" @default.
• W2151941372 creator A5028496657 @default.
• W2151941372 creator A5035934903 @default.
• W2151941372 creator A5063431050 @default.
• W2151941372 creator A5070862488 @default.
• W2151941372 date "2014-08-01" @default.
• W2151941372 modified "2023-10-12" @default.
• W2151941372 title "Dynamic Interaction of the Sec Translocon with the Chaperone PpiD" @default.
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• W2151941372 doi "https://doi.org/10.1074/jbc.m114.577916" @default.
• W2151941372 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4118129" @default.
• W2151941372 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24951590" @default.
• W2151941372 hasPublicationYear "2014" @default.
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