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- W2151941766 abstract "ABSTRACT Lethal and sterility mutations were accumulated in a cage population which was initiated with lethal- and sterility-free second chromosomes of D. melanogaster. It took about 2,000 days for the frequencies of these genes to reach equilibrium levels, i.e., 18% lethal and 9% male-sterile chromosomes. Two other cage populations which were initiated with random chromosomes sampled from natural populations and kept for more than eleven years in the laboratory showed 19-20% lethal content. The elimination rates of lethals by homozygosis in these populations were smaller than the mutation rate. By using Nei's formulae, the deleterious effect of a lethal gene in heterozygous condition (h) was estimated to be 0.035. The effective population number in the cage populations was estimated to be 1,000-2,900, while the actual population number was 3,500-7,800." @default.
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- W2151941766 date "1977-07-25" @default.
- W2151941766 modified "2023-09-26" @default.
- W2151941766 title "ACCUMULATION OF DELETERIOUS GENES IN A CAGE POPULATION OF DROSOPHILA MELANOGASTER" @default.
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- W2151941766 doi "https://doi.org/10.1093/genetics/86.3.657" @default.
- W2151941766 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1213701" @default.
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