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- W2151978148 abstract "Allergen-specific immunotherapy has been used for 100 years as a desensitizing therapy for allergic diseases and represents the potentially curative and specific method of treatment. The mechanisms of action of allergen-specific immunotherapy include the very early desensitization effects, modulation of T-and B-cell responses and related antibody isotypes, and migration of eosinophils, basophils, and mast cells to tissues, as well as release of their mediators. Regulatory T (Treg) cells have been identified as key regulators of immunologic processes in peripheral tolerance to allergens. Skewing of allergen-specific effector T cells to a regulatory phenotype appears as a key event in the development of healthy immune response to allergens and successful outcome in patients undergoing allergen-specific immunotherapy. Naturally occurring forkhead box protein 3-positive CD4(+)CD25(+) Treg cells and inducible T(R)1 cells contribute to the control of allergen-specific immune responses in several major ways, which can be summarized as suppression of dendritic cells that support the generation of effector T cells; suppression of effector T(H)1, T(H)2, and T(H)17 cells; suppression of allergen-specific IgE and induction of IgG4; suppression of mast cells, basophils, and eosinophils; and suppression of effector T-cell migration to tissues. New strategies for immune intervention will likely include targeting of the molecular mechanisms of allergen tolerance and reciprocal regulation of effector and Treg cell subsets." @default.
- W2151978148 created "2016-06-24" @default.
- W2151978148 creator A5055404517 @default.
- W2151978148 date "2011-01-01" @default.
- W2151978148 modified "2023-10-17" @default.
- W2151978148 title "Mechanisms of allergen-specific immunotherapy" @default.
- W2151978148 cites W101977310 @default.
- W2151978148 cites W1532147512 @default.
- W2151978148 cites W1737741632 @default.
- W2151978148 cites W1782561717 @default.
- W2151978148 cites W1965731762 @default.
- W2151978148 cites W1966329929 @default.
- W2151978148 cites W1970050631 @default.
- W2151978148 cites W1973850474 @default.
- W2151978148 cites W1976602395 @default.
- W2151978148 cites W1976640573 @default.
- W2151978148 cites W1976970013 @default.
- W2151978148 cites W1977149533 @default.
- W2151978148 cites W1977919951 @default.
- W2151978148 cites W1978258603 @default.
- W2151978148 cites W1980566957 @default.
- W2151978148 cites W1980705107 @default.
- W2151978148 cites W1984973837 @default.
- W2151978148 cites W1986235780 @default.
- W2151978148 cites W1986864699 @default.
- W2151978148 cites W1987032872 @default.
- W2151978148 cites W1987628377 @default.
- W2151978148 cites W1990128650 @default.
- W2151978148 cites W1994095603 @default.
- W2151978148 cites W1995545916 @default.
- W2151978148 cites W1998652423 @default.
- W2151978148 cites W1999799838 @default.
- W2151978148 cites W2001776200 @default.
- W2151978148 cites W2002361100 @default.
- W2151978148 cites W2002892444 @default.
- W2151978148 cites W2004542916 @default.
- W2151978148 cites W2005219111 @default.
- W2151978148 cites W2005264846 @default.
- W2151978148 cites W2005284010 @default.
- W2151978148 cites W2010704609 @default.
- W2151978148 cites W2012077729 @default.
- W2151978148 cites W2012390790 @default.
- W2151978148 cites W2013255276 @default.
- W2151978148 cites W2014666620 @default.
- W2151978148 cites W2016175222 @default.
- W2151978148 cites W2020342012 @default.
- W2151978148 cites W2022300311 @default.
- W2151978148 cites W2025691876 @default.
- W2151978148 cites W2026536594 @default.
- W2151978148 cites W2026545194 @default.
- W2151978148 cites W2032062642 @default.
- W2151978148 cites W2033177777 @default.
- W2151978148 cites W2035023446 @default.
- W2151978148 cites W2035394952 @default.
- W2151978148 cites W2037178393 @default.
- W2151978148 cites W2037259928 @default.
- W2151978148 cites W2037873372 @default.
- W2151978148 cites W2038386610 @default.
- W2151978148 cites W2040637363 @default.
- W2151978148 cites W2041302559 @default.
- W2151978148 cites W2041899741 @default.
- W2151978148 cites W2043837854 @default.
- W2151978148 cites W2044951483 @default.
- W2151978148 cites W2046257532 @default.
- W2151978148 cites W2047121064 @default.
- W2151978148 cites W2050387062 @default.
- W2151978148 cites W2050514166 @default.
- W2151978148 cites W2050656150 @default.
- W2151978148 cites W2052063445 @default.
- W2151978148 cites W2052873213 @default.
- W2151978148 cites W2061178990 @default.
- W2151978148 cites W2063177917 @default.
- W2151978148 cites W2063850268 @default.
- W2151978148 cites W2067550159 @default.
- W2151978148 cites W2068471769 @default.
- W2151978148 cites W2068643209 @default.
- W2151978148 cites W2068898313 @default.
- W2151978148 cites W2072383922 @default.
- W2151978148 cites W2075875408 @default.
- W2151978148 cites W2077806468 @default.
- W2151978148 cites W2079282933 @default.
- W2151978148 cites W2080229642 @default.
- W2151978148 cites W2080725704 @default.
- W2151978148 cites W2085092023 @default.
- W2151978148 cites W2085466684 @default.
- W2151978148 cites W2089346000 @default.
- W2151978148 cites W2092762767 @default.
- W2151978148 cites W2094295893 @default.
- W2151978148 cites W2095224028 @default.
- W2151978148 cites W2098156552 @default.
- W2151978148 cites W2105507544 @default.
- W2151978148 cites W2107235439 @default.
- W2151978148 cites W2107470605 @default.
- W2151978148 cites W2107553722 @default.
- W2151978148 cites W2108578856 @default.
- W2151978148 cites W2110957620 @default.
- W2151978148 cites W2112571043 @default.
- W2151978148 cites W2114743889 @default.